Protein: O60568 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O60568 (Uniprot)	PLOD3_HUMAN	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	human	Yes

Protein Function

Uniprot: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.

Dissimilar Functions Manual Curation

Function 1: Lysyl hydroxylase.

Function 2: Collagen glucosyltransferase.

Publications (PMID): 10934207

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
567	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 15 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001701	in utero embryonic development	IEA
GO:0001886	endothelial cell morphogenesis	IEA
GO:0006493	protein O-linked glycosylation	IMP
GO:0008104	protein localization	IEA
GO:0017185	peptidyl-lysine hydroxylation	IDA
GO:0021915	neural tube development	IEA
GO:0030199	collagen fibril organization	IEA
GO:0032870	cellular response to hormone stimulus	IEA
GO:0032963	collagen metabolic process	IEA
GO:0042311	vasodilation	IEA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005783	endoplasmic reticulum	TAS
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0005794	Golgi apparatus	IDA
GO:0005802	trans-Golgi network	IEA
GO:0030867	rough endoplasmic reticulum membrane	IEA
GO:0031012	extracellular matrix	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 19 entries

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Interactor	Also a MoonDB EMF protein
A2ABF9_HUMAN	No
CC85B_HUMAN	No
COHA1_HUMAN	No
COIL_HUMAN	No
DPPA2_HUMAN	No
EFHC2_HUMAN	No
EHMT2_HUMAN	No
F153A_HUMAN	No
IP6K2_HUMAN	No
KCTD9_HUMAN	No

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Publications Associated

Showing 1 to 9 of 9 entries

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PMID	Article Title
9582318	Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3).
9724729	Cloning and characterization of a third human lysyl hydroxylase isoform.
10686427	Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3).
12853948	The DNA sequence of human chromosome 7.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18834968	A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.
21269460	Initial characterization of the human central proteome.
25944712	N-terminome analysis of the human mitochondrial proteome.

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OMIM Diseases Associated

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OMIM ID	Disease Name
612394	Lysyl hydroxylase 3 deficiency

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Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
2OG-FeII_Oxy	PF03171	Pfam
FE2OG_OXY	PS51471	PROSITE
LYS_HYDROXYLASE	PS01325	PROSITE
Nucleotide-diphossugar_trans	IPR029044	InterPro
Oxoglu/Fe-dep_dioxygenase	IPR005123	InterPro
P4Hc	SM00702	SMART
Pro_4_hyd_alph	IPR006620	InterPro
Procol_lys_dOase	IPR001006	InterPro
SSF53448	SSF53448	SUPFAM

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