Protein: Q9Y6I3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y6I3 (Uniprot) EPN1_HUMAN EPN1 Epsin-1 human Yes
Uniprot: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Dissimilar Functions Manual Curation

Function 1: Binds to membranes. Regulates receptor-mediated endocytosis. Condition: cytoplasm or cell membrane localisation.

Function 2: Binds PLZF transcription factor. Condition: nuclear localisation (import via interaction with PLZF, export via interaction with CRM1)

Publications (PMID): 10791968, 11425879

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
134 GO:0005829 cytosol
134 GO:0005634 nucleus
368 GO:0005829 cytosol
368 GO:0005634 nucleus
368 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001701 in utero embryonic development IEA
GO:0006897 endocytosis IEA
GO:0007219 Notch signaling pathway IEA
GO:0007565 female pregnancy IEA
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0048568 embryonic organ development IEA
GO:0061024 membrane organization TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005905 clathrin-coated pit IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
PMID Article Title
10557078 Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.
10764745 Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
12775724 RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
12836669 Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16516836 Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18199683 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
18669648 A quantitative atlas of mitotic phosphorylation.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
UIM_dom IPR003903 InterPro
ENTH_VHS IPR008942 InterPro
ENTH IPR013809 InterPro
ENTH PF01417 Pfam
UIM PS50330 PROSITE
ENTH PS50942 PROSITE
ENTH SM00273 SMART
UIM SM00726 SMART
SSF48464 SSF48464 SUPFAM