Protein: Q9Y3E5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y3E5 (Uniprot) PTH2_HUMAN PTRH2 Peptidyl-tRNA hydrolase 2, mitochondrial human Yes
Uniprot: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
Dissimilar Functions Manual Curation

Function 1: Peptidyl-tRNA hydrolase. The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Condition: mitochondrion localisation.

Function 2: Apoptosis promoter, binds transcriptional co-repressors (AES and TLE1). Condition: cytoplasmic localisation (during apoptosis).

Publications (PMID): 15006356

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
238 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
238 GO:0005829 cytosol
238 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process IEA
GO:0010629 negative regulation of gene expression IMP
GO:2000210 positive regulation of anoikis IMP
GO:2000811 negative regulation of anoikis IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005739 mitochondrion IMP
GO:0005829 cytosol IMP
GO:0016020 membrane IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
AES_HUMAN Yes: Q08117 (MoonDB)
PMID Article Title
10810093 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
14660562 Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15006356 A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25558065 Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.
25574476 Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.
25621951 USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
25944712 N-terminome analysis of the human mitochondrial proteome.
OMIM ID Disease Name
616263 Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset
Domain Name Domain ID Source
PTH2 IPR002833 InterPro
Pep_tRNA_hydro_II_dom_sf IPR023476 InterPro
PTH2 PF01981 Pfam
SSF102462 SSF102462 SUPFAM
T46479 T46479 PIR
arch_pth2 TIGR00283 TIGRFAMs
PTH2 cd02430 CDD