Protein: Q9JL25 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9JL25 (Uniprot)	RGS1_MOUSE	Rgs1	Regulator of G-protein signaling 1	mouse	No

Protein Function

Uniprot: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006810	transport	1565	GO:0009059	macromolecule biosynthetic process	1675	1.20e-73	5.64e-54

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MoonDB Network Modules

Biological Processes

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
1565	GO:0046907	intracellular transport
1675	GO:0034645	cellular macromolecule biosynthetic process
1675	GO:0044271	cellular nitrogen compound biosynthetic process
1675	GO:0010467	gene expression
2024	GO:0009966	regulation of signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1565	GO:0005829	cytosol
1675	GO:0005829	cytosol
1675	GO:0005634	nucleus
2024	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007165	signal transduction	ISO
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	IEA
GO:0009968	negative regulation of signal transduction	IEA
GO:0043547	positive regulation of GTPase activity	ISO
GO:0061737	leukotriene signaling pathway	ISO

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	ISO
GO:0005886	plasma membrane	TAS
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BICD2_MOUSE	No
EIF3G_MOUSE	No
SKAP2_MOUSE	No

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Publications Associated

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PMID	Article Title
10779778	RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072	The transcriptional landscape of the mammalian genome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 10 entries

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Domain Name	Domain ID	Source
PTHR10845:SF34	PTHR10845:SF34	PANTHER
RGS	IPR016137	InterPro
RGS	PF00615	Pfam
RGS	PS50132	PROSITE
RGS	SM00315	SMART
RGS1	IPR030409	InterPro
RGS_sf	IPR036305	InterPro
RGS_subdom1	IPR024066	InterPro
RGSPROTEIN	PR01301	PRINTS
SSF48097	SSF48097	SUPFAM

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