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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9JL25
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9JL25 (Uniprot)
RGS1_MOUSE
Rgs1
Regulator of G-protein signaling 1
mouse
No
Protein Function
Uniprot:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits
thereby driving them into their inactive GDP-bound form (By similarity).
more..
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006810
transport
1565
GO:0009059
macromolecule biosynthetic process
1675
1.20e-73
5.64e-54
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MoonDB Network Modules
Biological Processes
Showing 1 to 5 of 5 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1565
GO:0046907
intracellular transport
1675
GO:0034645
cellular macromolecule biosynthetic process
1675
GO:0044271
cellular nitrogen compound biosynthetic process
1675
GO:0010467
gene expression
2024
GO:0009966
regulation of signal transduction
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Cellular Components
Showing 1 to 4 of 4 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1565
GO:0005829
cytosol
1675
GO:0005829
cytosol
1675
GO:0005634
nucleus
2024
GO:0005886
plasma membrane
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Protein GO Annotations
Biological Processes
Showing 1 to 6 of 6 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0007165
signal transduction
ISO
GO:0007186
G-protein coupled receptor signaling pathway
TAS
GO:0008277
regulation of G-protein coupled receptor protein signaling pathway
IEA
GO:0009968
negative regulation of signal transduction
IEA
GO:0043547
positive regulation of GTPase activity
ISO
GO:0061737
leukotriene signaling pathway
ISO
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Cellular Components
Showing 1 to 4 of 4 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005737
cytoplasm
IBA
GO:0005829
cytosol
ISO
GO:0005886
plasma membrane
TAS
GO:0031234
extrinsic component of cytoplasmic side of plasma membrane
ISO
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 3 of 3 entries
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Interactor
Also a MoonDB EMF protein
BICD2_MOUSE
No
EIF3G_MOUSE
No
SKAP2_MOUSE
No
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Publications Associated
Showing 1 to 3 of 3 entries
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PMID
Article Title
10779778
RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072
The transcriptional landscape of the mammalian genome.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 10 entries
Search:
Domain Name
Domain ID
Source
PTHR10845:SF34
PTHR10845:SF34
PANTHER
RGS
IPR016137
InterPro
RGS
PF00615
Pfam
RGS
PS50132
PROSITE
RGS
SM00315
SMART
RGS1
IPR030409
InterPro
RGS_sf
IPR036305
InterPro
RGS_subdom1
IPR024066
InterPro
RGSPROTEIN
PR01301
PRINTS
SSF48097
SSF48097
SUPFAM
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