Protein: Q9CR42 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9CR42 (Uniprot)	ANKR1_MOUSE	Ankrd1	Ankyrin repeat domain-containing protein 1	mouse	No

Protein Function

Uniprot: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	1456	GO:0048583	regulation of response to stimulus	2116	7.81e-03	6.10e-16
GO:0034641	cellular nitrogen compound metabolic process	1869	GO:0048583	regulation of response to stimulus	2116	3.00e-06	3.03e-16

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1429	GO:0045893	positive regulation of transcription, DNA-templated
1429	GO:0006357	regulation of transcription from RNA polymerase II promoter
1438	GO:0031325	positive regulation of cellular metabolic process
1438	GO:0010604	positive regulation of macromolecule metabolic process
1438	GO:0051173	positive regulation of nitrogen compound metabolic process
1438	GO:0006355	regulation of transcription, DNA-templated
1446	GO:0016070	RNA metabolic process
1446	GO:0071310	cellular response to organic substance
1446	GO:0010467	gene expression
1446	GO:0031325	positive regulation of cellular metabolic process

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Cellular Components

Showing 1 to 10 of 28 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
1429	GO:0031981	nuclear lumen
1438	GO:0031981	nuclear lumen
1446	GO:0005634	nucleus
1448	GO:0031981	nuclear lumen
1456	GO:0098588	bounding membrane of organelle
1456	GO:0031410	cytoplasmic vesicle
1456	GO:0012505	endomembrane system
1456	GO:0043233	organelle lumen
1456	GO:0005886	plasma membrane
1456	GO:0012506	vesicle membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA
GO:0010976	positive regulation of neuron projection development	IEA
GO:0035690	cellular response to drug	IDA
GO:0035914	skeletal muscle cell differentiation	IMP
GO:0035994	response to muscle stretch	ISO
GO:0043065	positive regulation of apoptotic process	ISO
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO
GO:0045445	myoblast differentiation	IBA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0001650	fibrillar center	ISO
GO:0005634	nucleus	IDA
GO:0005667	transcription factor complex	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	ISO
GO:0030016	myofibril	IDA
GO:0031674	I band	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005667	transcription factor complex	GO:0005737	cytoplasm	8.51e-03	3.68e-18

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACTN1_MOUSE	No
AGTRA_MOUSE	No
BRMS1_MOUSE	No
CAN3_MOUSE	No
CAV3_MOUSE	No
CBPD_MOUSE	No
DESM_MOUSE	No
EIF3D_MOUSE	No
EWS_MOUSE	No
FRIH_MOUSE	No

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Publications Associated

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PMID	Article Title
9043061	CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
9278441	A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072	The transcriptional landscape of the mammalian genome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
ANK	SM00248	SMART
ANK	cd00204	CDD
Ank_2	PF12796	Pfam
ANK_REP_REGION	PS50297	PROSITE
ANK_REPEAT	PS50088	PROSITE
Ankyrin_rpt	IPR002110	InterPro
Ankyrin_rpt-contain_dom	IPR020683	InterPro
Ankyrin_rpt-contain_sf	IPR036770	InterPro
SSF48403	SSF48403	SUPFAM

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