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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9CR42
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9CR42 (Uniprot)
ANKR1_MOUSE
Ankrd1
Ankyrin repeat domain-containing protein 1
mouse
No
Protein Function
Uniprot:
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
MoonDB Dissimilar Functions
Showing 1 to 2 of 2 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006725
cellular aromatic compound metabolic process
1456
GO:0048583
regulation of response to stimulus
2116
7.81e-03
6.10e-16
GO:0034641
cellular nitrogen compound metabolic process
1869
GO:0048583
regulation of response to stimulus
2116
3.00e-06
3.03e-16
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 110 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1429
GO:0045893
positive regulation of transcription, DNA-templated
1429
GO:0006357
regulation of transcription from RNA polymerase II promoter
1438
GO:0031325
positive regulation of cellular metabolic process
1438
GO:0010604
positive regulation of macromolecule metabolic process
1438
GO:0051173
positive regulation of nitrogen compound metabolic process
1438
GO:0006355
regulation of transcription, DNA-templated
1446
GO:0016070
RNA metabolic process
1446
GO:0071310
cellular response to organic substance
1446
GO:0010467
gene expression
1446
GO:0031325
positive regulation of cellular metabolic process
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Cellular Components
Showing 1 to 10 of 28 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1429
GO:0031981
nuclear lumen
1438
GO:0031981
nuclear lumen
1446
GO:0005634
nucleus
1448
GO:0031981
nuclear lumen
1456
GO:0098588
bounding membrane of organelle
1456
GO:0031410
cytoplasmic vesicle
1456
GO:0012505
endomembrane system
1456
GO:0043233
organelle lumen
1456
GO:0005886
plasma membrane
1456
GO:0012506
vesicle membrane
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 20 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IEA
GO:0006357
regulation of transcription from RNA polymerase II promoter
IDA
GO:0010976
positive regulation of neuron projection development
IEA
GO:0035690
cellular response to drug
IDA
GO:0035914
skeletal muscle cell differentiation
IMP
GO:0035994
response to muscle stretch
ISO
GO:0043065
positive regulation of apoptotic process
ISO
GO:0043517
positive regulation of DNA damage response, signal transduction by p53 class mediator
ISO
GO:0045445
myoblast differentiation
IBA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IEA
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Cellular Components
Showing 1 to 7 of 7 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0001650
fibrillar center
ISO
GO:0005634
nucleus
IDA
GO:0005667
transcription factor complex
IDA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
ISO
GO:0030016
myofibril
IDA
GO:0031674
I band
IDA
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Dissimilar Cellular Components (PrOnto)
Showing 1 to 1 of 1 entries
Search:
GO ID 1
Component 1
GO ID 2
Component 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0005667
transcription factor complex
GO:0005737
cytoplasm
8.51e-03
3.68e-18
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All Protein Interactions
Showing 1 to 10 of 27 entries
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Interactor
Also a MoonDB EMF protein
ACTN1_MOUSE
No
AGTRA_MOUSE
No
BRMS1_MOUSE
No
CAN3_MOUSE
No
CAV3_MOUSE
No
CBPD_MOUSE
No
DESM_MOUSE
No
EIF3D_MOUSE
No
EWS_MOUSE
No
FRIH_MOUSE
No
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Publications Associated
Showing 1 to 4 of 4 entries
Search:
PMID
Article Title
9043061
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
9278441
A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072
The transcriptional landscape of the mammalian genome.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 9 of 9 entries
Search:
Domain Name
Domain ID
Source
ANK
SM00248
SMART
ANK
cd00204
CDD
Ank_2
PF12796
Pfam
ANK_REP_REGION
PS50297
PROSITE
ANK_REPEAT
PS50088
PROSITE
Ankyrin_rpt
IPR002110
InterPro
Ankyrin_rpt-contain_dom
IPR020683
InterPro
Ankyrin_rpt-contain_sf
IPR036770
InterPro
SSF48403
SSF48403
SUPFAM
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