Protein: Q9BYE9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9BYE9 (Uniprot) CDHR2_HUMAN CDHR2 Cadherin-related family member 2 human No
Uniprot: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 668 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 669 2.53e-05 1.12e-11
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
668 GO:0006464 cellular protein modification process
668 GO:0006796 phosphate-containing compound metabolic process
669 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
669 GO:0090675 intermicrovillar adhesion
669 GO:0032532 regulation of microvillus length
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
669 GO:0016324 apical plasma membrane
669 GO:0031526 brush border membrane
669 GO:0070062 extracellular exosome
669 GO:0031528 microvillus membrane
669 GO:0044214 spanning component of plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
GO:0030855 epithelial cell differentiation IDA
GO:0032532 regulation of microvillus length IMP
GO:0044331 cell-cell adhesion mediated by cadherin IDA
GO:0060243 negative regulation of cell growth involved in contact inhibition IDA
GO:0090675 intermicrovillar adhesion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005903 brush border IDA
GO:0016324 apical plasma membrane IDA
GO:0030054 cell junction IEA
GO:0031526 brush border membrane IDA
GO:0031528 microvillus membrane IDA
GO:0044214 spanning component of plasma membrane IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
MAST2_HUMAN No
CDHR5_HUMAN No
PMID Article Title
12117771 Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15534908 Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.
18987736 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24725409 Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.
26812017 Mechanistic basis of organization of the Harmonin/USH1C-mediated brush border microvilli tip-link complex.
26812018 ANKS4B is essential for intermicrovillar adhesion complex formation.
No results found.
Domain Name Domain ID Source
Cadherin IPR002126 InterPro
Cadherin-like IPR015919 InterPro
Cadherin_CS IPR020894 InterPro
CDHR2 IPR030276 InterPro
Cadherin PF00028 Pfam
CADHERIN PR00205 PRINTS
CADHERIN_1 PS00232 PROSITE
CADHERIN_2 PS50268 PROSITE
PTHR44787 PTHR44787 PANTHER
CA SM00112 SMART
SSF49313 SSF49313 SUPFAM