Protein: Q60591

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q60591 (Uniprot) NFAC2_MOUSE Nfatc2 Nuclear factor of activated T-cells, cytoplasmic 2 mouse No
Uniprot: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1701 GO:0007165 signal transduction 1917 2.28e-48 1.95e-17
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1437 GO:0035556 intracellular signal transduction
1437 GO:0010604 positive regulation of macromolecule metabolic process
1437 GO:0051173 positive regulation of nitrogen compound metabolic process
1437 GO:0048584 positive regulation of response to stimulus
1437 GO:0006357 regulation of transcription from RNA polymerase II promoter
1462 GO:0044267 cellular protein metabolic process
1462 GO:0031325 positive regulation of cellular metabolic process
1462 GO:0010604 positive regulation of macromolecule metabolic process
1462 GO:0051173 positive regulation of nitrogen compound metabolic process
1462 GO:0006357 regulation of transcription from RNA polymerase II promoter
1701 GO:0034645 cellular macromolecule biosynthetic process
1701 GO:0006974 cellular response to DNA damage stimulus
1701 GO:0090304 nucleic acid metabolic process
1701 GO:0034654 nucleobase-containing compound biosynthetic process
1711 GO:0045893 positive regulation of transcription, DNA-templated
1711 GO:0006357 regulation of transcription from RNA polymerase II promoter
1917 GO:0035556 intracellular signal transduction
1917 GO:0048584 positive regulation of response to stimulus
1929 GO:0048646 anatomical structure formation involved in morphogenesis
1929 GO:0007166 cell surface receptor signaling pathway
1929 GO:0051094 positive regulation of developmental process
1929 GO:0022603 regulation of anatomical structure morphogenesis
1929 GO:0045595 regulation of cell differentiation
1929 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1437 GO:0005829 cytosol
1462 GO:0005654 nucleoplasm
1701 GO:0044454 nuclear chromosome part
1701 GO:0005654 nucleoplasm
1711 GO:0005634 nucleus
1929 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001816 cytokine production IDA
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006974 cellular response to DNA damage stimulus ISO
GO:0010628 positive regulation of gene expression IMP
GO:0014904 myotube cell development IMP
GO:0016477 cell migration ISO
GO:0030890 positive regulation of B cell proliferation ISO
GO:0033173 calcineurin-NFAT signaling cascade IGI
GO:0042493 response to drug ISO
GO:0045893 positive regulation of transcription, DNA-templated ISO
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0050853 B cell receptor signaling pathway ISO
GO:1901741 positive regulation of myoblast fusion IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005667 transcription factor complex IPI
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0030529 intracellular ribonucleoprotein complex IDA
GO:0044798 nuclear transcription factor complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005667 transcription factor complex GO:0005737 cytoplasm 8.51e-03 3.68e-18
PMID Article Title
7876165 A similar DNA-binding motif in NFAT family proteins and the Rel homology region.
8235597 Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
8668213 Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.
8943202 NF-AT-driven interleukin-4 transcription potentiated by NIP45.
9660947 Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.
10089876 Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
11278367 Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain.
18675896 Alternative splicing and expression of human and mouse NFAT genes.
19468303 Lineage-specific biology revealed by a finished genome assembly of the mouse.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
23616576 Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.
No results found.
Domain Name Domain ID Source
A48753 A48753 PIR
IPT_dom IPR002909 InterPro
NFAT IPR008366 InterPro
p53-like_TF_DNA-bd IPR008967 InterPro
RHD_DNA_bind_dom IPR011539 InterPro
Ig-like_fold IPR013783 InterPro
Ig_E-set IPR014756 InterPro
RHD_dimer IPR032397 InterPro
RHD_DNA_bind_dom_sf IPR037059 InterPro
RHD_DNA_bind PF00554 Pfam
RHD_dimer PF16179 Pfam
NUCFACTORATC PR01789 PRINTS
REL_2 PS50254 PROSITE
PTHR12533 PTHR12533 PANTHER
IPT SM00429 SMART
SSF49417 SSF49417 SUPFAM
SSF81296 SSF81296 SUPFAM