Protein: Q12018

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q12018 (Uniprot) CDC53_YEAST CDC53 Cell division control protein 53 yeast No
Uniprot: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1139 GO:0009056 catabolic process 1141 3.10e-17 2.99e-04
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1010 GO:0010467 gene expression
1010 GO:0090304 nucleic acid metabolic process
1010 GO:0019538 protein metabolic process
1010 GO:0060255 regulation of macromolecule metabolic process
1139 GO:0034645 cellular macromolecule biosynthetic process
1139 GO:0044271 cellular nitrogen compound biosynthetic process
1139 GO:0044267 cellular protein metabolic process
1141 GO:0044248 cellular catabolic process
1141 GO:1903047 mitotic cell cycle process
1141 GO:0090304 nucleic acid metabolic process
1141 GO:2000112 regulation of cellular macromolecule biosynthetic process
1141 GO:0010468 regulation of gene expression
1141 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1010 GO:0005634 nucleus
1139 GO:0005634 nucleus
1141 GO:0044427 chromosomal part
1141 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000082 G1/S transition of mitotic cell cycle IMP
GO:0000086 G2/M transition of mitotic cell cycle IGI
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
GO:0051301 cell division IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005737 cytoplasm IEA
GO:0019005 SCF ubiquitin ligase complex IPI
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005737 cytoplasm 5.14e-51 7.30e-86
PMID Article Title
7813440 Regulated degradation of the transcription factor Gcn4.
8943317 Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
8972577 Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV.
9169867 The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
9312054 The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast.
9346238 F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
9346239 A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
9499404 Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast.
9736614 The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex.
10213692 Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
10385629 Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.
11283612 Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
14562095 Global analysis of protein localization in budding yeast.
14562106 Global analysis of protein expression in yeast.
14747994 Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.
16421250 The F-box protein Dia2 regulates DNA replication.
19763088 A longevity protein, Lag2, interacts with SCF complex and regulates SCF function.
19942853 Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
Cullin_N IPR001373 InterPro
Cullin_CS IPR016157 InterPro
Cullin_homology IPR016158 InterPro
Cullin_repeat-like_dom_sf IPR016159 InterPro
Cullin_neddylation_domain IPR019559 InterPro
Cullin_homology_sf IPR036317 InterPro
WH-like_DNA-bd_sf IPR036388 InterPro
WH_DNA-bd_sf IPR036390 InterPro
Cullin PF00888 Pfam
Cullin_Nedd8 PF10557 Pfam
CULLIN_1 PS01256 PROSITE
CULLIN_2 PS50069 PROSITE
S67675 S67675 PIR
CULLIN SM00182 SMART
Cullin_Nedd8 SM00884 SMART
SSF46785 SSF46785 SUPFAM
SSF74788 SSF74788 SUPFAM
SSF75632 SSF75632 SUPFAM