Protein: Q06449 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q06449 (Uniprot)	PIN3_YEAST	PIN3	[PSI+] inducibility protein 3	yeast	No

Protein Function

Uniprot: Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0043170	macromolecule metabolic process	1073	GO:0097435	supramolecular fiber organization	1177	4.36e-08	1.57e-47

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1073	GO:0010467	gene expression
1177	GO:0007015	actin filament organization
1177	GO:0022607	cellular component assembly
1177	GO:0044087	regulation of cellular component biogenesis
1177	GO:0033043	regulation of organelle organization

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
884	GO:0043232	intracellular non-membrane-bounded organelle
984	GO:0012505	endomembrane system
996	GO:0005634	nucleus
1000	GO:0005634	nucleus
1177	GO:0005856	cytoskeleton
1177	GO:0005634	nucleus
1199	GO:0005634	nucleus
1216	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	IPI

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IDA
GO:0030479	actin cortical patch	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

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All Protein Interactions

Showing 1 to 10 of 44 entries

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Interactor	Also a MoonDB EMF protein
2ABA_YEAST	No
AIM3_YEAST	No
APP1_YEAST	No
ATC8_YEAST	No
BSP1_YEAST	No
ENG2_YEAST	No
FES1_YEAST	No
GIS1_YEAST	No
GYL1_YEAST	No
GYP5_YEAST	No

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Publications Associated

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PMID	Article Title
9169875	The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
10512884	The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex.
11511345	Prions affect the appearance of other prions: the story of [PIN(+)].
12872131	A proteomics approach to understanding protein ubiquitination.
14562095	Global analysis of protein localization in budding yeast.
14562106	Global analysis of protein expression in yeast.
17322287	Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
19779198	Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
21777813	Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.
22000681	Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
S61138	S61138	PIR
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3-like_dom_sf	IPR036028	InterPro
SH3_1	PF00018	Pfam
SH3_domain	IPR001452	InterPro
SH3DOMAIN	PR00452	PRINTS
SSF50044	SSF50044	SUPFAM

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