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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q06449
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q06449 (Uniprot)
PIN3_YEAST
PIN3
[PSI+] inducibility protein 3
yeast
No
Protein Function
Uniprot:
Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress.
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0043170
macromolecule metabolic process
1073
GO:0097435
supramolecular fiber organization
1177
4.36e-08
1.57e-47
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MoonDB Network Modules
Biological Processes
Showing 1 to 5 of 5 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1073
GO:0010467
gene expression
1177
GO:0007015
actin filament organization
1177
GO:0022607
cellular component assembly
1177
GO:0044087
regulation of cellular component biogenesis
1177
GO:0033043
regulation of organelle organization
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Cellular Components
Showing 1 to 8 of 8 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
884
GO:0043232
intracellular non-membrane-bounded organelle
984
GO:0012505
endomembrane system
996
GO:0005634
nucleus
1000
GO:0005634
nucleus
1177
GO:0005856
cytoskeleton
1177
GO:0005634
nucleus
1199
GO:0005634
nucleus
1216
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 1 of 1 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0034316
negative regulation of Arp2/3 complex-mediated actin nucleation
IPI
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Cellular Components
Showing 1 to 3 of 3 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IEA
GO:0005737
cytoplasm
IDA
GO:0030479
actin cortical patch
IDA
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Dissimilar Cellular Components (PrOnto)
Showing 1 to 1 of 1 entries
Search:
GO ID 1
Component 1
GO ID 2
Component 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0005634
nucleus
GO:0005737
cytoplasm
5.14e-51
7.30e-86
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All Protein Interactions
Showing 1 to 10 of 44 entries
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Interactor
Also a MoonDB EMF protein
2ABA_YEAST
No
AIM3_YEAST
No
APP1_YEAST
No
ATC8_YEAST
No
BSP1_YEAST
No
ENG2_YEAST
No
FES1_YEAST
No
GIS1_YEAST
No
GYL1_YEAST
No
GYP5_YEAST
No
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Publications Associated
Showing 1 to 10 of 13 entries
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PMID
Article Title
9169875
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
10512884
The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex.
11511345
Prions affect the appearance of other prions: the story of [PIN(+)].
12872131
A proteomics approach to understanding protein ubiquitination.
14562095
Global analysis of protein localization in budding yeast.
14562106
Global analysis of protein expression in yeast.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
19779198
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
21777813
Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.
22000681
Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 8 of 8 entries
Search:
Domain Name
Domain ID
Source
S61138
S61138
PIR
SH3
PS50002
PROSITE
SH3
SM00326
SMART
SH3-like_dom_sf
IPR036028
InterPro
SH3_1
PF00018
Pfam
SH3_domain
IPR001452
InterPro
SH3DOMAIN
PR00452
PRINTS
SSF50044
SSF50044
SUPFAM
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