Protein: P48601 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P48601 (Uniprot)	PRS4_DROME	Rpt2	26S proteasome regulatory subunit 4	fly	No

Protein Function

Uniprot: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	3174	GO:0006725	cellular aromatic compound metabolic process	3198	3.53e-09	8.83e-08

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
3174	GO:0044267	cellular protein metabolic process
3198	GO:0006139	nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
3174	GO:0005634	nucleus
3198	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006974	cellular response to DNA damage stimulus	IMP
GO:0007623	circadian rhythm	TAS
GO:0008063	Toll signaling pathway	TAS
GO:0030433	ubiquitin-dependent ERAD pathway	IBA
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IC
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	IBA
GO:1901800	positive regulation of proteasomal protein catabolic process	IEA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS
GO:0005838	proteasome regulatory particle	IDA
GO:0008540	proteasome regulatory particle, base subcomplex	IDA
GO:0031595	nuclear proteasome complex	IBA
GO:0031597	cytosolic proteasome complex	IBA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A0B4KF97_DROME	No
ACT3_DROME	No
ARP6_DROME	No
ATPB_DROME	No
CDK2_DROME	No
CSN4_DROME	No
JNK_DROME	No
M9NF85_DROME	No
MYSA_DROME	No
NGLY1_DROME	No

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Publications Associated

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PMID	Article Title
8808288	Genomic organization and mapping of the mouse P26s4 ATPase gene: a member of the remarkably conserved AAA gene family.
10731132	The genome sequence of Drosophila melanogaster.
12537569	A Drosophila full-length cDNA resource.
12537572	Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
23622245	Proteasome regulation by ADP-ribosylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 12 entries

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Domain Name	Domain ID	Source
26S_Psome_P45-like	IPR005937	InterPro
26S_subunit_4	IPR035244	InterPro
26Sp45	TIGR01242	TIGRFAMs
AAA	PF00004	Pfam
AAA	PS00674	PROSITE
AAA	SM00382	SMART
AAA+_ATPase	IPR003593	InterPro
ATPase_AAA_core	IPR003959	InterPro
ATPase_AAA_CS	IPR003960	InterPro
P-loop_NTPase	IPR027417	InterPro

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