Protein: P47992

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P47992 (Uniprot) XCL1_HUMAN XCL1 Lymphotactin human Yes
Uniprot: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Dissimilar Functions Manual Curation

Function 1: Lymphotactin chemokine, activates the G-protein coupled receptor XRC1 on taget leukocytes. Canonical chemokine fold. Condition: presence in a monomeric form.

Function 2: Binds glycosaminoglycans, unknown fold. Condition: presence in a dimeric form.

Publications (PMID): 18364395

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
726 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA
GO:0002548 monocyte chemotaxis IBA
GO:0002690 positive regulation of leukocyte chemotaxis ISS
GO:0002725 negative regulation of T cell cytokine production IDA
GO:0002726 positive regulation of T cell cytokine production ISS
GO:0002826 negative regulation of T-helper 1 type immune response IC
GO:0007165 signal transduction IC
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0007267 cell-cell signaling IDA
GO:0009615 response to virus IDA
GO:0010469 regulation of receptor activity IEA
GO:0010820 positive regulation of T cell chemotaxis IDA
GO:0030593 neutrophil chemotaxis TAS
GO:0032689 negative regulation of interferon-gamma production IDA
GO:0032703 negative regulation of interleukin-2 production IDA
GO:0032733 positive regulation of interleukin-10 production IDA
GO:0035782 mature natural killer cell chemotaxis IDA
GO:0043433 negative regulation of DNA binding transcription factor activity IDA
GO:0043547 positive regulation of GTPase activity IBA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0050727 regulation of inflammatory response IDA
GO:0051209 release of sequestered calcium ion into cytosol ISS
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
GO:0070098 chemokine-mediated signaling pathway IBA
GO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
GO:0071346 cellular response to interferon-gamma IBA
GO:0071347 cellular response to interleukin-1 IBA
GO:0071353 cellular response to interleukin-4 ISS
GO:0071356 cellular response to tumor necrosis factor IBA
GO:0071560 cellular response to transforming growth factor beta stimulus ISS
GO:0071636 positive regulation of transforming growth factor beta production IDA
GO:0071663 positive regulation of granzyme B production IDA
GO:0090023 positive regulation of neutrophil chemotaxis ISS
GO:2000412 positive regulation of thymocyte migration ISS
GO:2000503 positive regulation of natural killer cell chemotaxis IDA
GO:2000513 positive regulation of granzyme A production IDA
GO:2000518 negative regulation of T-helper 1 cell activation IDA
GO:2000538 positive regulation of B cell chemotaxis ISS
GO:2000553 positive regulation of T-helper 2 cell cytokine production ISS
GO:2000556 positive regulation of T-helper 1 cell cytokine production ISS
GO:2000558 positive regulation of immunoglobulin production in mucosal tissue ISS
GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation ISS
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IBA
GO:0005623 cell IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005623 cell 1.42e-118 1.37e-06
GO:0005615 extracellular space GO:0005623 cell 3.90e-77 8.83e-06
Interactor Also a MoonDB EMF protein
KR103_HUMAN No
XCR1_HUMAN No
PMID Article Title
7602097 Molecular cloning and functional characterization of human lymphotactin.
7615002 Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes.
7875320 Molecular cloning of a novel C or gamma type chemokine, SCM-1.
8849694 Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.
11601972 Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16710414 The DNA sequence and biological annotation of human chromosome 1.
No results found.
Domain Name Domain ID Source
Chemokine_IL8-like_dom IPR001811 InterPro
Chemokine_XCL1/XCL2 IPR008105 InterPro
Interleukin_8-like_sf IPR036048 InterPro
IL8 PF00048 Pfam
LYMPHOTACTIN PR01731 PRINTS
PTHR12015:SF101 PTHR12015:SF101 PANTHER
ETHUL S60650 PIR
SCY SM00199 SMART
SSF54117 SSF54117 SUPFAM
Chemokine_C cd00271 CDD