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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P42834
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P42834 (Uniprot)
MDJ2_YEAST
MDJ2
Mitochondrial DnaJ homolog 2
yeast
No
Protein Function
Uniprot:
Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006810
transport
1037
GO:0043170
macromolecule metabolic process
1195
1.58e-118
1.03e-131
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
1037
GO:0055085
transmembrane transport
1195
GO:0010467
gene expression
1195
GO:0043933
macromolecular complex subunit organization
1195
GO:0090304
nucleic acid metabolic process
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
1037
GO:0031090
organelle membrane
1195
GO:0044428
nuclear part
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0030150
protein import into mitochondrial matrix
IPI
GO:0032781
positive regulation of ATPase activity
IEA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0001405
presequence translocase-associated import motor
IPI
GO:0005743
mitochondrial inner membrane
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
ATP14_YEAST
Yes:
Q12349 (MoonDB)
ATC2_YEAST
No
Publications Associated
PMID
Article Title
7645347
Sequencing analysis of a 15.4 kb fragment of yeast chromosome XIV identifies the RPD3, PAS8 and KRE1 loci, five new open reading frames.
9169873
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
9325105
Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae.
14562095
Global analysis of protein localization in budding yeast.
14562106
Global analysis of protein expression in yeast.
16027163
The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
DnaJ_domain
IPR001623
InterPro
DnaJ_dom_sf
IPR036869
InterPro
DNAJ_2
PS50076
PROSITE
S55861
S55861
PIR
DnaJ
SM00271
SMART
SSF46565
SSF46565
SUPFAM
DnaJ
cd06257
CDD