Protein: P39428

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P39428 (Uniprot) TRAF1_MOUSE Traf1 TNF receptor-associated factor 1 mouse No
Uniprot: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1464, 1742, 1804, 1893, 1933 GO:0006725 cellular aromatic compound metabolic process 2052 1.72e-102 7.50e-20
GO:0034641 cellular nitrogen compound metabolic process 1555 GO:0007165 signal transduction 1464, 1742, 1804, 1893, 1933, 2104, 2105, 2115 1.18e-123 4.26e-23
GO:0034641 cellular nitrogen compound metabolic process 1555 GO:0030030 cell projection organization 1825 1.69e-13 1.03e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1452 GO:0010467 gene expression
1464 GO:0007166 cell surface receptor signaling pathway
1464 GO:0042981 regulation of apoptotic process
1464 GO:0009966 regulation of signal transduction
1464 GO:0006355 regulation of transcription, DNA-templated
1498 GO:0006355 regulation of transcription, DNA-templated
1501 GO:0031325 positive regulation of cellular metabolic process
1501 GO:0010604 positive regulation of macromolecule metabolic process
1501 GO:0051173 positive regulation of nitrogen compound metabolic process
1501 GO:0019538 protein metabolic process
1501 GO:0009966 regulation of signal transduction
1501 GO:0006355 regulation of transcription, DNA-templated
1555 GO:0044271 cellular nitrogen compound biosynthetic process
1555 GO:0044267 cellular protein metabolic process
1555 GO:0048584 positive regulation of response to stimulus
1555 GO:2000112 regulation of cellular macromolecule biosynthetic process
1555 GO:0010468 regulation of gene expression
1555 GO:0002682 regulation of immune system process
1555 GO:0009966 regulation of signal transduction
1577 GO:0071310 cellular response to organic substance
1577 GO:0006955 immune response
1577 GO:0043066 negative regulation of apoptotic process
1577 GO:0002684 positive regulation of immune system process
1577 GO:0051090 regulation of DNA binding transcription factor activity
1577 GO:2001236 regulation of extrinsic apoptotic signaling pathway
1705 GO:0010468 regulation of gene expression
1742 GO:0007166 cell surface receptor signaling pathway
1742 GO:0042981 regulation of apoptotic process
1742 GO:0006355 regulation of transcription, DNA-templated
1747 GO:0060255 regulation of macromolecule metabolic process
1747 GO:0009966 regulation of signal transduction
1804 GO:0007166 cell surface receptor signaling pathway
1804 GO:0051090 regulation of DNA binding transcription factor activity
1804 GO:0042981 regulation of apoptotic process
1804 GO:0051246 regulation of protein metabolic process
1804 GO:0009966 regulation of signal transduction
1806 GO:0006915 apoptotic process
1806 GO:0007166 cell surface receptor signaling pathway
1806 GO:0044093 positive regulation of molecular function
1806 GO:0000209 protein polyubiquitination
1806 GO:0043067 regulation of programmed cell death
1806 GO:0009966 regulation of signal transduction
1806 GO:0006355 regulation of transcription, DNA-templated
1825 GO:0048858 cell projection morphogenesis
1825 GO:0044093 positive regulation of molecular function
1825 GO:0006468 protein phosphorylation
1825 GO:0042981 regulation of apoptotic process
1825 GO:0010646 regulation of cell communication
1825 GO:0060255 regulation of macromolecule metabolic process
1825 GO:0023051 regulation of signaling
1825 GO:0007165 signal transduction
1874 GO:0007165 signal transduction
1893 GO:0097190 apoptotic signaling pathway
1893 GO:0010646 regulation of cell communication
1893 GO:0023051 regulation of signaling
1933 GO:0007166 cell surface receptor signaling pathway
1933 GO:0010467 gene expression
1933 GO:0015031 protein transport
1933 GO:0009966 regulation of signal transduction
2052 GO:0006139 nucleobase-containing compound metabolic process
2104 GO:0007166 cell surface receptor signaling pathway
2104 GO:0006355 regulation of transcription, DNA-templated
2105 GO:0007166 cell surface receptor signaling pathway
2105 GO:0044093 positive regulation of molecular function
2105 GO:0051090 regulation of DNA binding transcription factor activity
2105 GO:0042981 regulation of apoptotic process
2105 GO:0009966 regulation of signal transduction
2115 GO:0097190 apoptotic signaling pathway
2128 GO:0016070 RNA metabolic process
2128 GO:0010467 gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1452 GO:0005829 cytosol
1452 GO:0043232 intracellular non-membrane-bounded organelle
1452 GO:0005634 nucleus
1498 GO:0005634 nucleus
1501 GO:0005634 nucleus
1577 GO:0016021 integral component of membrane
1705 GO:0043232 intracellular non-membrane-bounded organelle
1804 GO:0016021 integral component of membrane
1825 GO:0120025 plasma membrane bounded cell projection
1825 GO:0005886 plasma membrane
1933 GO:0012505 endomembrane system
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process IEA
GO:0007165 signal transduction IEA
GO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
GO:2001236 regulation of extrinsic apoptotic signaling pathway ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8069916 A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
9104814 TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
11672546 TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
11804591 A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.
16141072 The transcriptional landscape of the mammalian genome.
16352630 TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
18429822 Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
18849341 FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
19144319 The phagosomal proteome in interferon-gamma-activated macrophages.
19468303 Lineage-specific biology revealed by a finished genome assembly of the mouse.
No results found.
Domain Name Domain ID Source
A54750 A54750 PIR
MATH/TRAF_dom IPR002083 InterPro
TRAF-like IPR008974 InterPro
TNF_rcpt--assoc_TRAF IPR012227 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
TRAF1 IPR027136 InterPro
TRAF_BIRC3-bd IPR032070 InterPro
TRAF1_MATH IPR037306 InterPro
TRAF_BIRC3_bd PF16673 Pfam
TRAF PIRSF015614 PIRSF
MATH PS50144 PROSITE
PTHR10131:SF91 PTHR10131:SF91 PANTHER
MATH SM00061 SMART
SSF49599 SSF49599 SUPFAM
MATH_TRAF1 cd03779 CDD