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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P39428
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P39428 (Uniprot)
TRAF1_MOUSE
Traf1
TNF receptor-associated factor 1
mouse
No
Protein Function
Uniprot:
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex
recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
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MoonDB Dissimilar Functions
Showing 1 to 3 of 3 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
1464
,
1742
,
1804
,
1893
,
1933
GO:0006725
cellular aromatic compound metabolic process
2052
1.72e-102
7.50e-20
GO:0034641
cellular nitrogen compound metabolic process
1555
GO:0007165
signal transduction
1464
,
1742
,
1804
,
1893
,
1933
,
2104
,
2105
,
2115
1.18e-123
4.26e-23
GO:0034641
cellular nitrogen compound metabolic process
1555
GO:0030030
cell projection organization
1825
1.69e-13
1.03e-07
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 70 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1452
GO:0010467
gene expression
1464
GO:0007166
cell surface receptor signaling pathway
1464
GO:0042981
regulation of apoptotic process
1464
GO:0009966
regulation of signal transduction
1464
GO:0006355
regulation of transcription, DNA-templated
1498
GO:0006355
regulation of transcription, DNA-templated
1501
GO:0031325
positive regulation of cellular metabolic process
1501
GO:0010604
positive regulation of macromolecule metabolic process
1501
GO:0051173
positive regulation of nitrogen compound metabolic process
1501
GO:0019538
protein metabolic process
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Cellular Components
Showing 1 to 10 of 11 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1452
GO:0005829
cytosol
1452
GO:0043232
intracellular non-membrane-bounded organelle
1452
GO:0005634
nucleus
1498
GO:0005634
nucleus
1501
GO:0005634
nucleus
1577
GO:0016021
integral component of membrane
1705
GO:0043232
intracellular non-membrane-bounded organelle
1804
GO:0016021
integral component of membrane
1825
GO:0120025
plasma membrane bounded cell projection
1825
GO:0005886
plasma membrane
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Protein GO Annotations
Biological Processes
Showing 1 to 4 of 4 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006915
apoptotic process
IEA
GO:0007165
signal transduction
IEA
GO:0051092
positive regulation of NF-kappaB transcription factor activity
ISO
GO:2001236
regulation of extrinsic apoptotic signaling pathway
ISO
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Cellular Components
Showing 1 to 1 of 1 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005737
cytoplasm
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 32 entries
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Interactor
Also a MoonDB EMF protein
AES_MOUSE
No
ANS4B_MOUSE
No
BANK1_MOUSE
No
CAR11_MOUSE
No
DNJA3_MOUSE
No
DTNB_MOUSE
No
FKBPL_MOUSE
No
HM20A_MOUSE
No
HM20B_MOUSE
No
IQGA1_MOUSE
No
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Publications Associated
Showing 1 to 10 of 10 entries
Search:
PMID
Article Title
8069916
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
9104814
TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
11672546
TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
11804591
A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.
16141072
The transcriptional landscape of the mammalian genome.
16352630
TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
18429822
Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
18849341
FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
19144319
The phagosomal proteome in interferon-gamma-activated macrophages.
19468303
Lineage-specific biology revealed by a finished genome assembly of the mouse.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 15 entries
Search:
Domain Name
Domain ID
Source
A54750
A54750
PIR
MATH
PS50144
PROSITE
MATH
SM00061
SMART
MATH/TRAF_dom
IPR002083
InterPro
MATH_TRAF1
cd03779
CDD
PTHR10131:SF91
PTHR10131:SF91
PANTHER
SSF49599
SSF49599
SUPFAM
TNF_rcpt--assoc_TRAF
IPR012227
InterPro
TRAF
PIRSF015614
PIRSF
TRAF-like
IPR008974
InterPro
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