Protein: P39428 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P39428 (Uniprot)	TRAF1_MOUSE	Traf1	TNF receptor-associated factor 1	mouse	No

Protein Function

Uniprot: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	1464, 1742, 1804, 1893, 1933	GO:0006725	cellular aromatic compound metabolic process	2052	1.72e-102	7.50e-20
GO:0034641	cellular nitrogen compound metabolic process	1555	GO:0007165	signal transduction	1464, 1742, 1804, 1893, 1933, 2104, 2105, 2115	1.18e-123	4.26e-23
GO:0034641	cellular nitrogen compound metabolic process	1555	GO:0030030	cell projection organization	1825	1.69e-13	1.03e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1452	GO:0010467	gene expression
1464	GO:0007166	cell surface receptor signaling pathway
1464	GO:0042981	regulation of apoptotic process
1464	GO:0009966	regulation of signal transduction
1464	GO:0006355	regulation of transcription, DNA-templated
1498	GO:0006355	regulation of transcription, DNA-templated
1501	GO:0031325	positive regulation of cellular metabolic process
1501	GO:0010604	positive regulation of macromolecule metabolic process
1501	GO:0051173	positive regulation of nitrogen compound metabolic process
1501	GO:0019538	protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1452	GO:0005829	cytosol
1452	GO:0043232	intracellular non-membrane-bounded organelle
1452	GO:0005634	nucleus
1498	GO:0005634	nucleus
1501	GO:0005634	nucleus
1577	GO:0016021	integral component of membrane
1705	GO:0043232	intracellular non-membrane-bounded organelle
1804	GO:0016021	integral component of membrane
1825	GO:0120025	plasma membrane bounded cell projection
1825	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006915	apoptotic process	IEA
GO:0007165	signal transduction	IEA
GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO
GO:2001236	regulation of extrinsic apoptotic signaling pathway	ISO

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Cellular Components

Showing 1 to 1 of 1 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AES_MOUSE	No
ANS4B_MOUSE	No
BANK1_MOUSE	No
CAR11_MOUSE	No
DNJA3_MOUSE	No
DTNB_MOUSE	No
FKBPL_MOUSE	No
HM20A_MOUSE	No
HM20B_MOUSE	No
IQGA1_MOUSE	No

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Publications Associated

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PMID	Article Title
8069916	A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
9104814	TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
11672546	TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
11804591	A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.
16141072	The transcriptional landscape of the mammalian genome.
16352630	TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
18429822	Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
18849341	FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
19144319	The phagosomal proteome in interferon-gamma-activated macrophages.
19468303	Lineage-specific biology revealed by a finished genome assembly of the mouse.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 15 entries

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Domain Name	Domain ID	Source
A54750	A54750	PIR
MATH	PS50144	PROSITE
MATH	SM00061	SMART
MATH/TRAF_dom	IPR002083	InterPro
MATH_TRAF1	cd03779	CDD
PTHR10131:SF91	PTHR10131:SF91	PANTHER
SSF49599	SSF49599	SUPFAM
TNF_rcpt--assoc_TRAF	IPR012227	InterPro
TRAF	PIRSF015614	PIRSF
TRAF-like	IPR008974	InterPro

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