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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P29055
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P29055 (Uniprot)
TF2B_YEAST
SUA7
Transcription initiation factor IIB
yeast
No
Protein Function
Uniprot:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0044260
cellular macromolecule metabolic process
915
,
1064
,
1111
GO:0015833
peptide transport
941
2.96e-17
2.61e-40
GO:0044260
cellular macromolecule metabolic process
915
,
1064
,
1111
GO:0006811
ion transport
1226
4.79e-76
5.35e-109
GO:0006139
nucleobase-containing compound metabolic process
1059
,
1078
GO:0006811
ion transport
1226
1.46e-19
8.47e-83
GO:0009987
cellular process
1066
GO:0006811
ion transport
1226
8.14e-56
7.39e-38
GO:0043170
macromolecule metabolic process
1083
,
1132
,
1219
GO:0015833
peptide transport
941
3.85e-11
1.47e-03
GO:0043170
macromolecule metabolic process
1083
,
1132
,
1219
GO:0006811
ion transport
1226
7.11e-80
2.62e-84
GO:0009059
macromolecule biosynthetic process
1139
,
1258
GO:0015833
peptide transport
941
5.69e-13
2.89e-52
GO:0009059
macromolecule biosynthetic process
1139
,
1258
GO:0006811
ion transport
1226
2.67e-40
7.66e-50
GO:0006725
cellular aromatic compound metabolic process
1220
GO:0006811
ion transport
1226
1.93e-19
6.20e-85
GO:0006811
ion transport
1226
GO:0034641
cellular nitrogen compound metabolic process
1337
4.44e-27
1.76e-86
GO:0006811
ion transport
1226
GO:0006351
transcription, DNA-templated
1378
2.52e-16
2.35e-48
GO:0006351
transcription, DNA-templated
1378
GO:0015833
peptide transport
941
7.52e-08
6.04e-70
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
915
GO:0016070
RNA metabolic process
915
GO:0010467
gene expression
915
GO:0060255
regulation of macromolecule metabolic process
941
GO:0015031
protein transport
1014
GO:0034622
cellular macromolecular complex assembly
1014
GO:0006139
nucleobase-containing compound metabolic process
1017
GO:0034314
Arp2/3 complex-mediated actin nucleation
1059
GO:0090304
nucleic acid metabolic process
1064
GO:0016070
RNA metabolic process
1064
GO:0044271
cellular nitrogen compound biosynthetic process
1064
GO:0010467
gene expression
1066
GO:0022402
cell cycle process
1066
GO:0022607
cellular component assembly
1066
GO:0000278
mitotic cell cycle
1066
GO:0090304
nucleic acid metabolic process
1078
GO:0090304
nucleic acid metabolic process
1078
GO:0060255
regulation of macromolecule metabolic process
1083
GO:0010467
gene expression
1083
GO:0006139
nucleobase-containing compound metabolic process
1111
GO:0016070
RNA metabolic process
1111
GO:0010467
gene expression
1132
GO:0010467
gene expression
1132
GO:0006139
nucleobase-containing compound metabolic process
1132
GO:0060255
regulation of macromolecule metabolic process
1139
GO:0034645
cellular macromolecule biosynthetic process
1139
GO:0044271
cellular nitrogen compound biosynthetic process
1139
GO:0044267
cellular protein metabolic process
1219
GO:0010467
gene expression
1220
GO:0006139
nucleobase-containing compound metabolic process
1226
GO:0006820
anion transport
1226
GO:0034654
nucleobase-containing compound biosynthetic process
1258
GO:0034645
cellular macromolecule biosynthetic process
1337
GO:0006139
nucleobase-containing compound metabolic process
1361
GO:0090304
nucleic acid metabolic process
1372
GO:0022402
cell cycle process
1372
GO:0034622
cellular macromolecular complex assembly
1378
GO:0006383
transcription from RNA polymerase III promoter
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
915
GO:0005634
nucleus
941
GO:0012505
endomembrane system
984
GO:0012505
endomembrane system
1014
GO:0005634
nucleus
1017
GO:0030479
actin cortical patch
1059
GO:0005634
nucleus
1064
GO:0005634
nucleus
1066
GO:0044454
nuclear chromosome part
1078
GO:0005634
nucleus
1083
GO:0005634
nucleus
1111
GO:0005634
nucleus
1139
GO:0005634
nucleus
1222
GO:0005634
nucleus
1293
GO:0016021
integral component of membrane
1306
GO:0012505
endomembrane system
1306
GO:0016021
integral component of membrane
1361
GO:0044427
chromosomal part
1361
GO:0031981
nuclear lumen
1372
GO:0044430
cytoskeletal part
1372
GO:0015630
microtubule cytoskeleton
1372
GO:0005634
nucleus
1378
GO:0044428
nuclear part
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0001113
transcriptional open complex formation at RNA polymerase II promoter
IMP
GO:0001174
transcriptional start site selection at RNA polymerase II promoter
IMP
GO:0006355
regulation of transcription, DNA-templated
IEA
GO:0051123
RNA polymerase II transcriptional preinitiation complex assembly
IMP
GO:2000679
positive regulation of transcription regulatory region DNA binding
IDA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IDA
GO:0097550
transcriptional preinitiation complex
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
SEC62_YEAST
No
YL294_YEAST
No
ADD37_YEAST
No
ALDH5_YEAST
No
ARL3_YEAST
No
ARP3_YEAST
No
ATP14_YEAST
Yes:
Q12349 (MoonDB)
ATPN_YEAST
No
ATX2_YEAST
No
BCD1_YEAST
No
BRE1_YEAST
No
BUD3_YEAST
No
C1TC_YEAST
No
CAF40_YEAST
No
CBT1_YEAST
No
CDC73_YEAST
No
COQ9_YEAST
No
CYC2_YEAST
No
DLHH_YEAST
No
EPS1_YEAST
No
ESS1_YEAST
No
ETFB_YEAST
No
FRE7_YEAST
No
FRM2_YEAST
No
FSF1_YEAST
No
GLGB_YEAST
No
GLRX7_YEAST
No
HIF1_YEAST
No
IES1_YEAST
No
IPB1_YEASX
No
KAPR_YEAST
No
LAM5_YEAST
No
LRE1_YEAST
No
MDY2_YEAST
No
MED6_YEAST
No
MED8_YEAST
No
MPM1_YEAST
No
NBA1_YEAST
No
NBP1_YEAST
No
NCA2_YEAST
No
NGG1_YEAST
No
OST6_YEAST
No
OXA1_YEAST
No
PAU12_YEAST
No
PEX11_YEAST
No
PMIP_YEAST
No
PPN1_YEAST
No
PRY1_YEAST
No
PSD10_YEAST
No
PSF2_YEAST
No
RFT1_YEAST
No
RIB2_YEAST
No
RIR3_YEAST
No
RLA1_YEAST
No
RM24_YEAST
No
RRF1_YEAST
No
RS7B_YEAST
No
RSB1_YEAST
No
RT102_YEAST
No
SAE3_YEAST
No
SAP30_YEAST
No
SCW10_YEAST
No
SEC65_YEAST
No
SLP1_YEAST
No
SNF8_YEAST
No
SPC97_YEAST
No
SPT20_YEAST
No
SRO7_YEAST
No
STU2_YEAST
No
SWD3_YEAST
No
SYYM_YEAST
No
T2FB_YEAST
No
TBP_YEAST
No
TDA10_YEAST
No
TDA6_YEAST
No
TEL2_YEAST
No
TFC7_YEAST
No
TIP20_YEAST
No
TOM6_YEAST
No
TRM6_YEAST
No
TYSY_YEAST
No
UBA3_YEAST
No
YA066_YEAST
No
YB59_YEAST
No
YD102_YEAST
No
YD158_YEAST
No
YD271_YEAST
No
YDR33_YEAST
No
YEQ6_YEAST
No
YG21_YEAST
No
YG62_YEAST
No
YHE4_YEAST
No
YHE5_YEAST
No
YL455_YEAST
No
YM94_YEAST
No
YMK8_YEAST
No
YNG1_YEAST
No
YO082_YEAST
No
YO150_YEAST
No
YORA4_YEAST
No
YPT1_YEAST
No
Publications Associated
PMID
Article Title
1547497
The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo.
9169875
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
14562106
Global analysis of protein expression in yeast.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
TFIIB
IPR000812
InterPro
Znf_TFIIB
IPR013137
InterPro
TFIIB_cyclin
IPR013150
InterPro
Cyclin-like
IPR013763
InterPro
TFIIB_CS
IPR023486
InterPro
Cyclin-like_sf
IPR036915
InterPro
TFIIB
PF00382
Pfam
TF_Zn_Ribbon
PF08271
Pfam
TIFACTORIIB
PR00685
PRINTS
TFIIB
PS00782
PROSITE
ZF_TFIIB
PS51134
PROSITE
PTHR11618
PTHR11618
PANTHER
S26707
S26707
PIR
CYCLIN
SM00385
SMART
SSF47954
SSF47954
SUPFAM
CYCLIN
cd00043
CDD