Protein: P23219

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P23219 (Uniprot) PGH1_HUMAN PTGS1 Prostaglandin G/H synthase 1 human Yes
Uniprot: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. more..
Dissimilar Functions Manual Curation

Function 1: Heme-dependant peroxidase.

Function 2: Cyclooxygenase. Both isozymes known to have the dual function. Condition: for the cyclooxygenase activities of PGHS-1 and PGHS-2 to function, the heme group at the peroxidase site must undergo a lipid peroxide-dependent oxidation.

Publications (PMID): 8121489, 11413152

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
877 GO:0070887 cellular response to chemical stimulus
877 GO:0019371 cyclooxygenase pathway
877 GO:0006954 inflammatory response
877 GO:0055114 oxidation-reduction process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
877 GO:0005789 endoplasmic reticulum membrane
877 GO:0005615 extracellular space
877 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001516 prostaglandin biosynthetic process ISS
GO:0006629 lipid metabolic process NAS
GO:0006805 xenobiotic metabolic process TAS
GO:0006954 inflammatory response IEA
GO:0006979 response to oxidative stress IEA
GO:0008217 regulation of blood pressure ISS
GO:0019371 cyclooxygenase pathway TAS
GO:0042127 regulation of cell proliferation IEA
GO:0055114 oxidation-reduction process IEA
GO:0098869 cellular oxidant detoxification IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001750 photoreceptor outer segment IEA
GO:0005634 nucleus ISS
GO:0005737 cytoplasm IDA
GO:0005789 endoplasmic reticulum membrane TAS
GO:0005794 Golgi apparatus IDA
GO:0031090 organelle membrane IEA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0031090 organelle membrane 1.06e-37 1.89e-52
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
Interactor Also a MoonDB EMF protein
PTGIS_HUMAN No
PMID Article Title
1587858 Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.
1734857 Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).
1907252 Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment.
2512924 Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
10966456 Cyclooxygenases: structural, cellular, and molecular biology.
12192304 Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053 DNA sequence and analysis of human chromosome 9.
15308583 Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141368 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention.
24605250 Aspirin, cyclooxygenase inhibition and colorectal cancer.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
HsPGHS01 3320 PeroxiBase
EGF-like_dom IPR000742 InterPro
Haem_peroxidase IPR010255 InterPro
Haem_peroxidase_animal IPR019791 InterPro
COX-1 IPR029580 InterPro
Haem_peroxidase_sf IPR037120 InterPro
JH0259 JH0259 PIR
EGF PF00008 Pfam
An_peroxidase PF03098 Pfam
ANPEROXIDASE PR00457 PRINTS
EGF_3 PS50026 PROSITE
PEROXIDASE_3 PS50292 PROSITE
PTHR11903:SF6 PTHR11903:SF6 PANTHER
SSF48113 SSF48113 SUPFAM