Protein: P21399 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P21399 (Uniprot)	ACOC_HUMAN	ACO1	Cytoplasmic aconitate hydratase	human	Yes

Protein Function

Uniprot: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are more..

Dissimilar Functions Manual Curation

Function 1: Functions as aconitase, citrate to isocitrate. Binds sulfur-iron clusters. Condition: high cellular iron concentration.

Function 2: Functions as mRNA binding protein by binding several IRE in the 3' untranslated region of the transferrin receptor mRNA and controls the degradation of transferrin receptor mRNA. Condition: low cellular iron concentration.

Publications (PMID): 1334546, 1444477, 18261896, 15877277

MoonDB Network Modules

Biological Processes

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
225	GO:0016070	RNA metabolic process
225	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
225	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

Showing 1 to 7 of 7 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006099	tricarboxylic acid cycle	IEA
GO:0006101	citrate metabolic process	IDA
GO:0006417	regulation of translation	IEA
GO:0006879	cellular iron ion homeostasis	TAS
GO:0009791	post-embryonic development	IEA
GO:0010040	response to iron(II) ion	IDA
GO:0050892	intestinal absorption	IEA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	NAS
GO:0005739	mitochondrion	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005794	Golgi apparatus	IDA
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 6 of 6 entries

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Interactor	Also a MoonDB EMF protein
CCD69_HUMAN	No
CLH1_HUMAN	Yes: Q00610 (MoonDB)
MYPC1_HUMAN	No
NEBU_HUMAN	No
PAXI_HUMAN	No
SGCG_HUMAN	No

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Publications Associated

Showing 1 to 10 of 14 entries

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PMID	Article Title
1738601	Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
1903202	Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
1946430	A regulated RNA binding protein also possesses aconitase activity.
2172968	Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.
8041788	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.
15164053	DNA sequence and analysis of human chromosome 9.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16407072	Crystal structure of human iron regulatory protein 1 as cytosolic aconitase.
19762596	Control of iron homeostasis by an iron-regulated ubiquitin ligase.
19762597	An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 18 entries

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Domain Name	Domain ID	Source
Acnase/IPM_dHydase_lsu_aba_1/3	IPR015931	InterPro
Acoase/IPM_deHydtase_lsu_aba	IPR001030	InterPro
Aconitase	PF00330	Pfam
ACONITASE	PR00415	PRINTS
Aconitase/3IPM_dehydase_swvl	IPR015928	InterPro
Aconitase/IRP2	IPR006249	InterPro
ACONITASE_1	PS00450	PROSITE
aconitase_1	TIGR01341	TIGRFAMs
ACONITASE_2	PS01244	PROSITE
Aconitase_4Fe-4S_BS	IPR018136	InterPro

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