Protein: P21399

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P21399 (Uniprot) ACOC_HUMAN ACO1 Cytoplasmic aconitate hydratase human Yes
Uniprot: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are more..

Function 1: Functions as aconitase, citrate to isocitrate. Binds sulfur-iron clusters. Condition: high cellular iron concentration.

Function 2: Functions as mRNA binding protein by binding several IRE in the 3' untranslated region of the transferrin receptor mRNA and controls the degradation of transferrin receptor mRNA. Condition: low cellular iron concentration.

Publications (PMID): 1334546, 1444477, 18261896, 15877277

No pairs of PrOnto dissimilar CC GO terms found.
No results found.