Protein: P19971

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P19971 (Uniprot) TYPH_HUMAN TYMP Thymidine phosphorylase human Yes
Uniprot: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. more..
Dissimilar Functions Manual Curation

Function 1: Thymidine phosphorylase. Condition: cytoplasmic localisation.

Function 2: Platelet-derived endothelial cell growth factor. Condition: extracellular fluid.

Publications (PMID): 1570012

GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000002 mitochondrial genome maintenance IMP
GO:0001525 angiogenesis IEA
GO:0006206 pyrimidine nucleobase metabolic process IEA
GO:0006213 pyrimidine nucleoside metabolic process IMP
GO:0006935 chemotaxis IEA
GO:0010469 regulation of receptor activity IEA
GO:0030154 cell differentiation IEA
GO:0031641 regulation of myelination IMP
GO:0043097 pyrimidine nucleoside salvage TAS
GO:0046135 pyrimidine nucleoside catabolic process TAS
GO:0051969 regulation of transmission of nerve impulse IMP
GO:1905333 regulation of gastric motility IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
ZMY12_HUMAN No
PMID Article Title
1400349 Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.
1570012 Angiogenic factor.
1580101 Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.
1590793 Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
2467210 Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
9924029 Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.
10591208 The DNA sequence of human chromosome 22.
12177387 Phenotypic variability in a Spanish family with MNGIE.
14725767 Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16803458 Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.
19555658 Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.
21269460 Initial characterization of the human central proteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
603041 Mitochondrial DNA depletion syndrome 1, MNGIE type
Domain Name Domain ID Source
Thymidine/pyrmidine_PPase IPR000053 InterPro
Glycosyl_Trfase_fam3 IPR000312 InterPro
PYNP_C IPR013102 InterPro
Glycosyl_Trfase_fam3_N_dom IPR017459 InterPro
Pyrmidine_PPase_CS IPR017872 InterPro
Pyrmidine_PPas_bac/euk IPR018090 InterPro
Nuc_phospho_transferase IPR035902 InterPro
Glycosyl_Trfase_fam3_N_dom)sf IPR036320 InterPro
PYNP-like_C_sf IPR036566 InterPro
Glycos_transf_3 PF00591 Pfam
Glycos_trans_3N PF02885 Pfam
PYNP_C PF07831 Pfam
TP_PyNP PIRSF000478 PIRSF
THYMID_PHOSPHORYLASE PS00647 PROSITE
PTHR10515 PTHR10515 PANTHER
S03904 S03904 PIR
PYNP_C SM00941 SMART
SSF47648 SSF47648 SUPFAM
SSF52418 SSF52418 SUPFAM
SSF54680 SSF54680 SUPFAM
Y_phosphoryl TIGR02644 TIGRFAMs