Protein: P12063

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P12063 (Uniprot) SYYM_NEUCR cyt-18 Tyrosine--tRNA ligase, mitochondrial yeast Yes
Uniprot: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Has both an aminoacyl-tRNA synthetase activity and is involved in the splicing of group I introns. It acts in intron splicing by stabilizing the catalytically active structure of the intron. more..
Dissimilar Functions Manual Curation

Function 1: Mitochondrial tyrosyl tRNA synthetase.

Function 2: Promotes the folding of group I introns into the active self-splicing structure.

Publications (PMID): 12714060

No results found.
No results found.
No pairs of PrOnto dissimilar CC GO terms found.
No results found.
PMID Article Title
2143700 Function of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases.
3607872 A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof.
12655011 What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.
12712197 The genome sequence of the filamentous fungus Neurospora crassa.
No results found.
Domain Name Domain ID Source
SYNCYT A27158 PIR
aa-tRNA-synth_I_CS IPR001412 InterPro
aa-tRNA-synth_Ic IPR002305 InterPro
Tyr-tRNA-ligase IPR002307 InterPro
Rossmann-like_a/b/a_fold IPR014729 InterPro
Tyr-tRNA-ligase_bac-type IPR024088 InterPro
TyrRSs_C IPR032005 InterPro
S4_RNA-bd_sf IPR036986 InterPro
tRNA-synt_1b PF00579 Pfam
TyrRSs_C PF16714 Pfam
TRNASYNTHTYR PR01040 PRINTS
AA_TRNA_LIGASE_I PS00178 PROSITE
PTHR11766 PTHR11766 PANTHER
tyrS TIGR00234 TIGRFAMs
TyrRS_core cd00805 CDD