Protein: P08183

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P08183 (Uniprot) MDR1_HUMAN ABCB1 Multidrug resistance protein 1 human Yes
Uniprot: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Dissimilar Functions Manual Curation

Function 1: P-glycoprotein (transporter). Multi-pass membrane protein. Condition: membrane localisation.

Function 2: Regulation of volume-activated chloride channels.

Publications (PMID): 8887537, 10790147

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
511 GO:0010467 gene expression
511 GO:0051252 regulation of RNA metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
511 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle IDA
GO:0006810 transport TAS
GO:0006855 drug transmembrane transport IEA
GO:0042493 response to drug TAS
GO:0042908 xenobiotic transport IEA
GO:0045332 phospholipid translocation IDA
GO:0047484 regulation of response to osmotic stress IMP
GO:0055085 transmembrane transport TAS
GO:0072089 stem cell proliferation IMP
GO:0099040 ceramide translocation IDA
GO:1901529 positive regulation of anion channel activity IMP
GO:2001225 regulation of chloride transport IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005886 plasma membrane TAS
GO:0009986 cell surface IDA
GO:0016020 membrane TAS
GO:0016021 integral component of membrane IEA
GO:0016324 apical plasma membrane IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1967175 Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
1972623 mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles.
2568832 P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.
2876781 Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
2897240 An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
9038218 Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
9473242 Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.
10716719 Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.
10790226 A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein.
11240981 Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.
11258197 ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.
11829140 Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.
12853948 The DNA sequence of human chromosome 7.
14610718 MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15488952 Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.
15618700 Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).
15618713 Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18669648 A quantitative atlas of mitotic phosphorylation.
21269460 Initial characterization of the human central proteome.
24333728 Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.
OMIM ID Disease Name
612244 Inflammatory bowel disease 13
Domain Name Domain ID Source
DVHU1 A34914 PIR
ABC_transporter-like IPR003439 InterPro
AAA+_ATPase IPR003593 InterPro
ABC1_TM_dom IPR011527 InterPro
ABC_transporter_CS IPR017871 InterPro
P-loop_NTPase IPR027417 InterPro
MDR1 IPR030258 InterPro
ABC1_TM_sf IPR036640 InterPro
ABC_tran PF00005 Pfam
ABC_membrane PF00664 Pfam
ABC_TRANSPORTER_1 PS00211 PROSITE
ABC_TRANSPORTER_2 PS50893 PROSITE
ABC_TM1F PS50929 PROSITE
PTHR24221:SF251 PTHR24221:SF251 PANTHER
AAA SM00382 SMART
SSF52540 SSF52540 SUPFAM
SSF90123 SSF90123 SUPFAM