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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: O88470
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
O88470 (Uniprot)
FOXL2_MOUSE
Foxl2
Forkhead box protein L2
mouse
No
Protein Function
Uniprot:
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activi
ty in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0034641
cellular nitrogen compound metabolic process
1554
GO:0007165
signal transduction
1623
1.18e-123
4.26e-23
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 66 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1462
GO:0044267
cellular protein metabolic process
1462
GO:0031325
positive regulation of cellular metabolic process
1462
GO:0010604
positive regulation of macromolecule metabolic process
1462
GO:0051173
positive regulation of nitrogen compound metabolic process
1462
GO:0006357
regulation of transcription from RNA polymerase II promoter
1526
GO:0006355
regulation of transcription, DNA-templated
1540
GO:0044267
cellular protein metabolic process
1540
GO:0010467
gene expression
1540
GO:0006796
phosphate-containing compound metabolic process
1540
GO:0060255
regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 10 of 17 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1462
GO:0005654
nucleoplasm
1526
GO:0005634
nucleus
1540
GO:0031981
nuclear lumen
1553
GO:0044421
extracellular region part
1554
GO:0031981
nuclear lumen
1623
GO:0005634
nucleus
1675
GO:0005829
cytosol
1675
GO:0005634
nucleus
1683
GO:0005654
nucleoplasm
1715
GO:0031981
nuclear lumen
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 19 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IMP
GO:0001541
ovarian follicle development
IGI
GO:0001555
oocyte growth
IEA
GO:0002074
extraocular skeletal muscle development
ISO
GO:0006309
apoptotic DNA fragmentation
ISO
GO:0006366
transcription from RNA polymerase II promoter
IEA
GO:0007338
single fertilization
IGI
GO:0008585
female gonad development
IGI
GO:0019101
female somatic sex determination
IMP
GO:0033686
positive regulation of luteinizing hormone secretion
IGI
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IDA
GO:0045171
intercellular bridge
ISO
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 24 entries
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Interactor
Also a MoonDB EMF protein
AFG31_MOUSE
No
BAF_MOUSE
No
CGRF1_MOUSE
No
CREM_MOUSE
No
CXXC5_MOUSE
No
E4F1_MOUSE
No
EIF3A_MOUSE
No
GMEB1_MOUSE
No
GNAI2_MOUSE
No
M0QWU0_MOUSE
No
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Publications Associated
Showing 1 to 8 of 8 entries
Search:
PMID
Article Title
9620855
Multistep signaling requirements for pituitary organogenesis in vivo.
12471206
Evolution and expression of FOXL2.
15059956
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
15944199
Foxl2 is required for commitment to ovary differentiation.
16153597
Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.
19106105
FoxL2 and Smad3 coordinately regulate follistatin gene transcription.
19797124
Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha.
20005806
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 13 entries
Search:
Domain Name
Domain ID
Source
FH
SM00339
SMART
FH
cd00059
CDD
FORK_HEAD_1
PS00657
PROSITE
FORK_HEAD_2
PS00658
PROSITE
FORK_HEAD_3
PS50039
PROSITE
Fork_head_dom
IPR001766
InterPro
Forkhead
PF00250
Pfam
FORKHEAD
PR00053
PRINTS
SSF46785
SSF46785
SUPFAM
TF_fork_head_CS_1
IPR018122
InterPro
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