Protein: O88470 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O88470 (Uniprot)	FOXL2_MOUSE	Foxl2	Forkhead box protein L2	mouse	No

Protein Function

Uniprot: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activi more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0034641	cellular nitrogen compound metabolic process	1554	GO:0007165	signal transduction	1623	1.18e-123	4.26e-23

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1462	GO:0044267	cellular protein metabolic process
1462	GO:0031325	positive regulation of cellular metabolic process
1462	GO:0010604	positive regulation of macromolecule metabolic process
1462	GO:0051173	positive regulation of nitrogen compound metabolic process
1462	GO:0006357	regulation of transcription from RNA polymerase II promoter
1526	GO:0006355	regulation of transcription, DNA-templated
1540	GO:0044267	cellular protein metabolic process
1540	GO:0010467	gene expression
1540	GO:0006796	phosphate-containing compound metabolic process
1540	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1462	GO:0005654	nucleoplasm
1526	GO:0005634	nucleus
1540	GO:0031981	nuclear lumen
1553	GO:0044421	extracellular region part
1554	GO:0031981	nuclear lumen
1623	GO:0005634	nucleus
1675	GO:0005829	cytosol
1675	GO:0005634	nucleus
1683	GO:0005654	nucleoplasm
1715	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0001541	ovarian follicle development	IGI
GO:0001555	oocyte growth	IEA
GO:0002074	extraocular skeletal muscle development	ISO
GO:0006309	apoptotic DNA fragmentation	ISO
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0007338	single fertilization	IGI
GO:0008585	female gonad development	IGI
GO:0019101	female somatic sex determination	IMP
GO:0033686	positive regulation of luteinizing hormone secretion	IGI

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0045171	intercellular bridge	ISO

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AFG31_MOUSE	No
BAF_MOUSE	No
CGRF1_MOUSE	No
CREM_MOUSE	No
CXXC5_MOUSE	No
E4F1_MOUSE	No
EIF3A_MOUSE	No
GMEB1_MOUSE	No
GNAI2_MOUSE	No
M0QWU0_MOUSE	No

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Publications Associated

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PMID	Article Title
9620855	Multistep signaling requirements for pituitary organogenesis in vivo.
12471206	Evolution and expression of FOXL2.
15059956	Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
15944199	Foxl2 is required for commitment to ovary differentiation.
16153597	Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.
19106105	FoxL2 and Smad3 coordinately regulate follistatin gene transcription.
19797124	Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha.
20005806	Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
FH	SM00339	SMART
FH	cd00059	CDD
FORK_HEAD_1	PS00657	PROSITE
FORK_HEAD_2	PS00658	PROSITE
FORK_HEAD_3	PS50039	PROSITE
Fork_head_dom	IPR001766	InterPro
Forkhead	PF00250	Pfam
FORKHEAD	PR00053	PRINTS
SSF46785	SSF46785	SUPFAM
TF_fork_head_CS_1	IPR018122	InterPro

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