Protein: O60568

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O60568 (Uniprot) PLOD3_HUMAN PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 human Yes
Uniprot: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Dissimilar Functions Manual Curation

Function 1: Lysyl hydroxylase.

Function 2: Collagen glucosyltransferase.

Publications (PMID): 10934207

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
567 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001701 in utero embryonic development IEA
GO:0001886 endothelial cell morphogenesis IEA
GO:0006493 protein O-linked glycosylation IMP
GO:0008104 protein localization IEA
GO:0017185 peptidyl-lysine hydroxylation IDA
GO:0021915 neural tube development IEA
GO:0030199 collagen fibril organization IEA
GO:0032870 cellular response to hormone stimulus IEA
GO:0032963 collagen metabolic process IEA
GO:0042311 vasodilation IEA
GO:0046947 hydroxylysine biosynthetic process IDA
GO:0048730 epidermis morphogenesis IEA
GO:0055114 oxidation-reduction process IEA
GO:0060425 lung morphogenesis IEA
GO:0070831 basement membrane assembly IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005783 endoplasmic reticulum TAS
GO:0005789 endoplasmic reticulum membrane TAS
GO:0005794 Golgi apparatus IDA
GO:0005802 trans-Golgi network IEA
GO:0030867 rough endoplasmic reticulum membrane IEA
GO:0031012 extracellular matrix IEA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9582318 Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3).
9724729 Cloning and characterization of a third human lysyl hydroxylase isoform.
10686427 Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3).
12853948 The DNA sequence of human chromosome 7.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18834968 A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.
21269460 Initial characterization of the human central proteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
OMIM ID Disease Name
612394 Lysyl hydroxylase 3 deficiency
Domain Name Domain ID Source
Procol_lys_dOase IPR001006 InterPro
Oxoglu/Fe-dep_dioxygenase IPR005123 InterPro
Pro_4_hyd_alph IPR006620 InterPro
Nucleotide-diphossugar_trans IPR029044 InterPro
2OG-FeII_Oxy PF03171 Pfam
LYS_HYDROXYLASE PS01325 PROSITE
FE2OG_OXY PS51471 PROSITE
P4Hc SM00702 SMART
SSF53448 SSF53448 SUPFAM