Protein: O14788

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O14788 (Uniprot) TNF11_HUMAN TNFSF11 Tumor necrosis factor ligand superfamily member 11 human No
Uniprot: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27 GO:0007165 signal transduction 355 1.10e-111 5.07e-25
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
393 GO:0044267 cellular protein metabolic process
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
796 GO:0034645 cellular macromolecule biosynthetic process
796 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
27 GO:0031981 nuclear lumen
101 GO:0005829 cytosol
101 GO:0043232 intracellular non-membrane-bounded organelle
355 GO:0044459 plasma membrane part
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
796 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001503 ossification IEA
GO:0002158 osteoclast proliferation IEA
GO:0002548 monocyte chemotaxis IDA
GO:0006955 immune response NAS
GO:0007257 activation of JUN kinase activity IEA
GO:0009887 animal organ morphogenesis IEA
GO:0010469 regulation of receptor activity IEA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0019722 calcium-mediated signaling ISS
GO:0030316 osteoclast differentiation NAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0033598 mammary gland epithelial cell proliferation IEA
GO:0034112 positive regulation of homotypic cell-cell adhesion IDA
GO:0038001 paracrine signaling IEA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0043406 positive regulation of MAP kinase activity IDA
GO:0045453 bone resorption IEA
GO:0045672 positive regulation of osteoclast differentiation IDA
GO:0045780 positive regulation of bone resorption IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0050870 positive regulation of T cell activation IDA
GO:0051091 positive regulation of DNA binding transcription factor activity ISS
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
GO:0051260 protein homooligomerization IEA
GO:0051466 positive regulation of corticotropin-releasing hormone secretion ISS
GO:0051897 positive regulation of protein kinase B signaling IEA
GO:0055074 calcium ion homeostasis IEA
GO:0060749 mammary gland alveolus development IEA
GO:0070371 ERK1 and ERK2 cascade IEA
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS
GO:0071847 TNFSF11-mediated signaling pathway IDA
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IDA
GO:1902533 positive regulation of intracellular signal transduction IDA
GO:1990830 cellular response to leukemia inhibitory factor IEA
GO:2001206 positive regulation of osteoclast development IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IEA
GO:0005737 cytoplasm IEA
GO:0005886 plasma membrane TAS
GO:0005887 integral component of plasma membrane NAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005737 cytoplasm GO:0005887 integral component of plasma membrane 4.51e-73 1.63e-08
PMID Article Title
9312132 TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.
9367155 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
9568710 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
10708588 Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17632511 Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.
22664871 Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin.
OMIM ID Disease Name
259710 Osteopetrosis, autosomal recessive 2
Domain Name Domain ID Source
TNF_dom IPR006052 InterPro
Tumour_necrosis_fac-like_dom IPR008983 InterPro
TNF_ligand_10/11 IPR017355 InterPro
TNF PF00229 Pfam
SSF49842 SSF49842 SUPFAM