Protein: E9Q401 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
E9Q401 (Uniprot)	RYR2_MOUSE	Ryr2	Ryanodine receptor 2	mouse	No

Protein Function

Uniprot: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due more..

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1758	GO:0007165	signal transduction	1492	2.28e-48	1.95e-17

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 13 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
1492	GO:0035556	intracellular signal transduction
1492	GO:0010646	regulation of cell communication
1492	GO:0060255	regulation of macromolecule metabolic process
1492	GO:0023051	regulation of signaling
1651	GO:0006464	cellular protein modification process
1758	GO:0034645	cellular macromolecule biosynthetic process
1758	GO:0034613	cellular protein localization
1758	GO:0045184	establishment of protein localization
1758	GO:0046907	intracellular transport
1758	GO:0031326	regulation of cellular biosynthetic process

Previous1 2Next

Cellular Components

Showing 1 to 6 of 6 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
1492	GO:0005634	nucleus
1492	GO:0005886	plasma membrane
1651	GO:0005829	cytosol
1651	GO:0005634	nucleus
1758	GO:0005789	endoplasmic reticulum membrane
1758	GO:0070062	extracellular exosome

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 39 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001666	response to hypoxia	IDA
GO:0002027	regulation of heart rate	IMP
GO:0003143	embryonic heart tube morphogenesis	IMP
GO:0003220	left ventricular cardiac muscle tissue morphogenesis	IMP
GO:0003300	cardiac muscle hypertrophy	IMP
GO:0005513	detection of calcium ion	ISO
GO:0006816	calcium ion transport	IMP
GO:0006874	cellular calcium ion homeostasis	IMP
GO:0010460	positive regulation of heart rate	IMP
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI

Previous1 2 3 4Next

Cellular Components

Showing 1 to 10 of 11 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005790	smooth endoplasmic reticulum	IDA
GO:0005886	plasma membrane	IBA
GO:0016020	membrane	IDA
GO:0016021	integral component of membrane	IC
GO:0016529	sarcoplasmic reticulum	IDA
GO:0030017	sarcomere	IDA
GO:0030018	Z disc	IDA
GO:0033017	sarcoplasmic reticulum membrane	IDA
GO:0034704	calcium channel complex	IDA
GO:0043234	protein complex	ISO

Previous1 2Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0016021	integral component of membrane	GO:0043234	protein complex	7.33e-100	3.60e-02

Previous1Next

All Protein Interactions

Showing 1 to 5 of 5 entries

Search:

Interactor	Also a MoonDB EMF protein
COPB_MOUSE	No
DYN2_MOUSE	No
G5E8J6_MOUSE	No
RYR1_MOUSE	No
TERA_MOUSE	No

Previous1Next

Publications Associated

Showing 1 to 10 of 15 entries

Search:

PMID	Article Title
7621815	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.
7876312	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.
9628868	Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.
10473538	Molecular identification of the ryanodine receptor pore-forming segment.
17693412	Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.
19468303	Lineage-specific biology revealed by a finished genome assembly of the mouse.
19913485	Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
20214899	Ryanodine receptor studies using genetically engineered mice.
20431056	Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.
21098440	Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

Previous1 2Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 42 entries

Search:

Domain Name	Domain ID	Source
B30.2/SPRY	IPR001870	InterPro
B302_SPRY	PS50188	PROSITE
ConA-like_dom_sf	IPR013320	InterPro
EF-hand-dom_pair	IPR011992	InterPro
EF-hand_8	PF13833	Pfam
EF_hand_dom	IPR002048	InterPro
I48742	I48742	PIR
Ins145_P3_rcpt	IPR014821	InterPro
Ins145_P3_rec	PF08709	Pfam
Ion_trans	PF00520	Pfam

Previous1 2 3 4 5Next