Protein: E9Q401

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
E9Q401 (Uniprot) RYR2_MOUSE Ryr2 Ryanodine receptor 2 mouse No
Uniprot: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1758 GO:0007165 signal transduction 1492 2.28e-48 1.95e-17
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1492 GO:0035556 intracellular signal transduction
1492 GO:0010646 regulation of cell communication
1492 GO:0060255 regulation of macromolecule metabolic process
1492 GO:0023051 regulation of signaling
1651 GO:0006464 cellular protein modification process
1758 GO:0034645 cellular macromolecule biosynthetic process
1758 GO:0034613 cellular protein localization
1758 GO:0045184 establishment of protein localization
1758 GO:0046907 intracellular transport
1758 GO:0031326 regulation of cellular biosynthetic process
1758 GO:0060341 regulation of cellular localization
1758 GO:0031399 regulation of protein modification process
1758 GO:0051049 regulation of transport
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1492 GO:0005634 nucleus
1492 GO:0005886 plasma membrane
1651 GO:0005829 cytosol
1651 GO:0005634 nucleus
1758 GO:0005789 endoplasmic reticulum membrane
1758 GO:0070062 extracellular exosome
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001666 response to hypoxia IDA
GO:0002027 regulation of heart rate IMP
GO:0003143 embryonic heart tube morphogenesis IMP
GO:0003220 left ventricular cardiac muscle tissue morphogenesis IMP
GO:0003300 cardiac muscle hypertrophy IMP
GO:0005513 detection of calcium ion ISO
GO:0006816 calcium ion transport IMP
GO:0006874 cellular calcium ion homeostasis IMP
GO:0010460 positive regulation of heart rate IMP
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling ISO
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
GO:0014850 response to muscle activity ISO
GO:0019722 calcium-mediated signaling IMP
GO:0030509 BMP signaling pathway IDA
GO:0031000 response to caffeine IDA
GO:0035584 calcium-mediated signaling using intracellular calcium source ISO
GO:0035994 response to muscle stretch ISO
GO:0051209 release of sequestered calcium ion into cytosol ISO
GO:0051284 positive regulation of sequestering of calcium ion ISO
GO:0051775 response to redox state ISO
GO:0055117 regulation of cardiac muscle contraction ISO
GO:0060048 cardiac muscle contraction ISO
GO:0060070 canonical Wnt signaling pathway IDA
GO:0060401 cytosolic calcium ion transport IMP
GO:0060402 calcium ion transport into cytosol ISO
GO:0070588 calcium ion transmembrane transport IMP
GO:0071313 cellular response to caffeine IDA
GO:0071872 cellular response to epinephrine stimulus IMP
GO:0072599 establishment of protein localization to endoplasmic reticulum ISO
GO:0086005 ventricular cardiac muscle cell action potential IMP
GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling IMP
GO:0097050 type B pancreatic cell apoptotic process IMP
GO:0098735 positive regulation of the force of heart contraction ISO
GO:0098904 regulation of AV node cell action potential ISO
GO:0098907 regulation of SA node cell action potential ISO
GO:0098910 regulation of atrial cardiac muscle cell action potential ISO
GO:0098911 regulation of ventricular cardiac muscle cell action potential ISO
GO:1901896 positive regulation of calcium-transporting ATPase activity ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005790 smooth endoplasmic reticulum IDA
GO:0005886 plasma membrane IBA
GO:0016020 membrane IDA
GO:0016021 integral component of membrane IC
GO:0016529 sarcoplasmic reticulum IDA
GO:0030017 sarcomere IDA
GO:0030018 Z disc IDA
GO:0033017 sarcoplasmic reticulum membrane IDA
GO:0034704 calcium channel complex IDA
GO:0043234 protein complex ISO
GO:0070062 extracellular exosome ISO
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0016021 integral component of membrane GO:0043234 protein complex 7.33e-100 3.60e-02
Interactor Also a MoonDB EMF protein
RYR1_MOUSE No
COPB_MOUSE No
DYN2_MOUSE No
G5E8J6_MOUSE No
TERA_MOUSE No
PMID Article Title
7621815 Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.
7876312 The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.
9628868 Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.
10473538 Molecular identification of the ryanodine receptor pore-forming segment.
17693412 Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.
19468303 Lineage-specific biology revealed by a finished genome assembly of the mouse.
19913485 Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
20214899 Ryanodine receptor studies using genetically engineered mice.
20431056 Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.
21098440 Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
21645850 The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching.
22705209 Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.
23978697 Type 2 ryanodine receptor domain A contains a unique and dynamic alpha-helix that transitions to a beta-strand in a mutant linked with a heritable cardiomyopathy.
26245150 Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
No results found.
Domain Name Domain ID Source
I48742 I48742 PIR
RIH_dom IPR000699 InterPro
B30.2/SPRY IPR001870 InterPro
EF_hand_dom IPR002048 InterPro
Ryanodine_rcpt IPR003032 InterPro
SPRY_dom IPR003877 InterPro
Ion_trans_dom IPR005821 InterPro
Ryanrecept_TM4-6 IPR009460 InterPro
EF-hand-dom_pair IPR011992 InterPro
ConA-like_dom_sf IPR013320 InterPro
Ryan_recept IPR013333 InterPro
RIH_assoc-dom IPR013662 InterPro
Ins145_P3_rcpt IPR014821 InterPro
Ryanodine_recept-rel IPR015925 InterPro
MIR_motif IPR016093 InterPro
SPRY1_RyR IPR035761 InterPro
SPRY3_RyR IPR035762 InterPro
SPRY2_RyR IPR035764 InterPro
IP3R_RIH_dom_sf IPR035910 InterPro
MIR_dom_sf IPR036300 InterPro
Ion_trans PF00520 Pfam
SPRY PF00622 Pfam
RYDR_ITPR PF01365 Pfam
RyR PF02026 Pfam
MIR PF02815 Pfam
RR_TM4-6 PF06459 Pfam
RIH_assoc PF08454 Pfam
Ins145_P3_rec PF08709 Pfam
EF-hand_8 PF13833 Pfam
RYANODINER PR00795 PRINTS
B302_SPRY PS50188 PROSITE
MIR PS50919 PROSITE
PTHR13715 PTHR13715 PANTHER
SPRY SM00449 SMART
MIR SM00472 SMART
SSF100909 SSF100909 SUPFAM
SSF47473 SSF47473 SUPFAM
SSF49899 SSF49899 SUPFAM
SSF82109 SSF82109 SUPFAM
SPRY1_RyR cd12877 CDD
SPRY2_RyR cd12878 CDD
SPRY3_RyR cd12879 CDD