Protein: P52286

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P52286 (Uniprot) SKP1_YEAST SKP1 Suppressor of kinetochore protein 1 yeast No
Uniprot: Essential component of the E3 ubiquitin ligase complex SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins like phosphorylated SIC1. Participates in the attachment of chromosomes to the spindle. Acts as a regulatory component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromeres and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly. SKP1/CBF3D could retrieve cyclins or cyclin-CDK-like proteins into the kinetochore thus providing cell cycle-regulated kinetochore activity. Involved in the regulation of methionine biosynthesis genes. Facilitates association of CDC53 with CDC4 and of ROY1 with YPT52. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1139 GO:0009056 catabolic process 1141 3.10e-17 2.99e-04
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1010 GO:0010467 gene expression
1010 GO:0090304 nucleic acid metabolic process
1010 GO:0019538 protein metabolic process
1010 GO:0060255 regulation of macromolecule metabolic process
1081 GO:0044267 cellular protein metabolic process
1139 GO:0034645 cellular macromolecule biosynthetic process
1139 GO:0044271 cellular nitrogen compound biosynthetic process
1139 GO:0044267 cellular protein metabolic process
1141 GO:0044248 cellular catabolic process
1141 GO:1903047 mitotic cell cycle process
1141 GO:0090304 nucleic acid metabolic process
1141 GO:2000112 regulation of cellular macromolecule biosynthetic process
1141 GO:0010468 regulation of gene expression
1141 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
954 GO:0043232 intracellular non-membrane-bounded organelle
1010 GO:0005634 nucleus
1114 GO:0005634 nucleus
1139 GO:0005634 nucleus
1141 GO:0044427 chromosomal part
1141 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000082 G1/S transition of mitotic cell cycle IMP
GO:0000086 G2/M transition of mitotic cell cycle IMP
GO:0000921 septin ring assembly IMP
GO:0007035 vacuolar acidification IMP
GO:0007096 regulation of exit from mitosis IPI
GO:0010458 exit from mitosis IMP
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
GO:0043254 regulation of protein complex assembly IPI
GO:0043623 cellular protein complex assembly IDA
GO:0045116 protein neddylation IMP
GO:0051382 kinetochore assembly IMP
GO:2000766 negative regulation of cytoplasmic translation IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000776 kinetochore TAS
GO:0000777 condensed chromosome kinetochore IEA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0019005 SCF ubiquitin ligase complex IPI
GO:0031518 CBF3 complex IGI
GO:0043291 RAVE complex IPI
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000776 kinetochore GO:0005737 cytoplasm 3.18e-02 1.76e-05
GO:0000777 condensed chromosome kinetochore GO:0005737 cytoplasm 8.42e-03 8.59e-10
GO:0005634 nucleus GO:0005737 cytoplasm 5.14e-51 7.30e-86
PMID Article Title
8670864 The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution.
8706131 SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
8706132 Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression.
9169867 The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
9346238 F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
9346239 A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
9499404 Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast.
10637232 Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30) complex.
11283612 Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
11287615 Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast.
12553912 Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.
14562095 Global analysis of protein localization in budding yeast.
14660673 The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.
15090617 Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function.
17322287 Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
17517885 Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p.
18407956 A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
21389113 Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
SKP1-like IPR001232 InterPro
SKP1/BTB/POZ_sf IPR011333 InterPro
Skp1_comp_dimer IPR016072 InterPro
Skp1_comp_POZ IPR016073 InterPro
SKP1 IPR016897 InterPro
SKP1-like_dim_sf IPR036296 InterPro
Skp1 PF01466 Pfam
Skp1_POZ PF03931 Pfam
E3_ubiquit_lig_SCF_Skp PIRSF028729 PIRSF
S59793 S59793 PIR
Skp1 SM00512 SMART
SSF54695 SSF54695 SUPFAM
SSF81382 SSF81382 SUPFAM