Protein: P32790 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P32790 (Uniprot)	SLA1_YEAST	SLA1	Actin cytoskeleton-regulatory complex protein SLA1	yeast	No

Protein Function

Uniprot: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membran more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	1004, 1058	GO:0097435	supramolecular fiber organization	1177	2.51e-08	1.12e-36
GO:0006355	regulation of transcription, DNA-templated	905	GO:0097435	supramolecular fiber organization	1177	1.28e-02	2.42e-24
GO:0097435	supramolecular fiber organization	1177	GO:0009059	macromolecule biosynthetic process	1202, 1285	2.11e-07	3.47e-31
GO:0097435	supramolecular fiber organization	1177	GO:0044260	cellular macromolecule metabolic process	1311	6.22e-07	4.50e-41

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
905	GO:0006357	regulation of transcription from RNA polymerase II promoter
990	GO:0006464	cellular protein modification process
1004	GO:0090304	nucleic acid metabolic process
1058	GO:0090304	nucleic acid metabolic process
1177	GO:0007015	actin filament organization
1177	GO:0022607	cellular component assembly
1177	GO:0044087	regulation of cellular component biogenesis
1177	GO:0033043	regulation of organelle organization
1202	GO:0034645	cellular macromolecule biosynthetic process
1202	GO:0044271	cellular nitrogen compound biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
884	GO:0043232	intracellular non-membrane-bounded organelle
893	GO:0005634	nucleus
905	GO:0005634	nucleus
914	GO:0043232	intracellular non-membrane-bounded organelle
923	GO:0005634	nucleus
931	GO:0005634	nucleus
982	GO:0043232	intracellular non-membrane-bounded organelle
982	GO:0005634	nucleus
986	GO:0016021	integral component of membrane
990	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000147	actin cortical patch assembly	IMP
GO:0006897	endocytosis	IMP
GO:0006898	receptor-mediated endocytosis	IEA
GO:0007015	actin filament organization	IEA
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	IPI

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IMP
GO:0005886	plasma membrane	IEA
GO:0005938	cell cortex	IDA
GO:0010008	endosome membrane	IEA
GO:0030479	actin cortical patch	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	2.94e-56	3.82e-107
GO:0005634	nucleus	GO:0005938	cell cortex	8.51e-06	1.01e-06
GO:0005634	nucleus	GO:0010008	endosome membrane	2.09e-05	2.97e-02

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All Protein Interactions

Showing 1 to 10 of 117 entries

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Interactor	Also a MoonDB EMF protein
ABP1_YEAST	No
ACK1_YEAST	No
AIM21_YEAST	No
AIM3_YEAST	No
ALG10_YEAST	No
AP2_YEAST	No
AP2A_YEAST	No
APP1_YEAST	No
ATM_YEAST	No
ATR1_YEAST	No

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Publications Associated

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PMID	Article Title
1441753	Sequence of a 12.7 kb segment of yeast chromosome II identifies a PDR-like gene and several new open reading frames.
7813418	Complete DNA sequence of yeast chromosome II.
8335689	Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae.
8756649	The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae.
9008707	A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection.
9024694	Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton.
9128251	High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.
10198057	Sla1p is a functionally modular component of the yeast cortical actin cytoskeleton required for correct localization of both Rho1p-GTPase and Sla2p, a protein with talin homology.
10594004	Pan1p, End3p, and Sla1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis.
11739778	Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 17 entries

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Domain Name	Domain ID	Source
PTHR11216:SF55	PTHR11216:SF55	PANTHER
S25327	S25327	PIR
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3-like_dom_sf	IPR036028	InterPro
SH3_1	PF00018	Pfam
SH3_9	PF14604	Pfam
SH3_domain	IPR001452	InterPro
SH3_Sla1p_1	cd11773	CDD
SH3_Sla1p_3	cd11775	CDD

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