Protein: P32790

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P32790 (Uniprot) SLA1_YEAST SLA1 Actin cytoskeleton-regulatory complex protein SLA1 yeast No
Uniprot: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006355 regulation of transcription, DNA-templated 905 GO:0097435 supramolecular fiber organization 1177 1.28e-02 2.42e-24
GO:0006139 nucleobase-containing compound metabolic process 1004, 1058 GO:0097435 supramolecular fiber organization 1177 2.51e-08 1.12e-36
GO:0097435 supramolecular fiber organization 1177 GO:0009059 macromolecule biosynthetic process 1202, 1285 2.11e-07 3.47e-31
GO:0097435 supramolecular fiber organization 1177 GO:0044260 cellular macromolecule metabolic process 1311 6.22e-07 4.50e-41
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
905 GO:0006357 regulation of transcription from RNA polymerase II promoter
990 GO:0006464 cellular protein modification process
1004 GO:0090304 nucleic acid metabolic process
1058 GO:0090304 nucleic acid metabolic process
1177 GO:0007015 actin filament organization
1177 GO:0022607 cellular component assembly
1177 GO:0044087 regulation of cellular component biogenesis
1177 GO:0033043 regulation of organelle organization
1202 GO:0034645 cellular macromolecule biosynthetic process
1202 GO:0044271 cellular nitrogen compound biosynthetic process
1202 GO:0010467 gene expression
1202 GO:0090304 nucleic acid metabolic process
1285 GO:0034645 cellular macromolecule biosynthetic process
1296 GO:0006338 chromatin remodeling
1296 GO:0006355 regulation of transcription, DNA-templated
1297 GO:0034622 cellular macromolecular complex assembly
1297 GO:0006897 endocytosis
1311 GO:0016070 RNA metabolic process
1311 GO:0010467 gene expression
1311 GO:0031326 regulation of cellular biosynthetic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
884 GO:0043232 intracellular non-membrane-bounded organelle
893 GO:0005634 nucleus
905 GO:0005634 nucleus
914 GO:0043232 intracellular non-membrane-bounded organelle
923 GO:0005634 nucleus
931 GO:0005634 nucleus
982 GO:0043232 intracellular non-membrane-bounded organelle
982 GO:0005634 nucleus
986 GO:0016021 integral component of membrane
990 GO:0005634 nucleus
1004 GO:0005634 nucleus
1012 GO:0043232 intracellular non-membrane-bounded organelle
1058 GO:0043232 intracellular non-membrane-bounded organelle
1058 GO:0005634 nucleus
1069 GO:0043232 intracellular non-membrane-bounded organelle
1069 GO:0005634 nucleus
1074 GO:0016021 integral component of membrane
1125 GO:0005634 nucleus
1177 GO:0005856 cytoskeleton
1177 GO:0005634 nucleus
1187 GO:0005634 nucleus
1202 GO:0043232 intracellular non-membrane-bounded organelle
1202 GO:0005634 nucleus
1285 GO:0005634 nucleus
1296 GO:0016587 Isw1 complex
1297 GO:0030479 actin cortical patch
1297 GO:0012505 endomembrane system
1297 GO:0005634 nucleus
1309 GO:0016021 integral component of membrane
1311 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000147 actin cortical patch assembly IMP
GO:0006897 endocytosis IMP
GO:0006898 receptor-mediated endocytosis IEA
GO:0007015 actin filament organization IEA
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IPI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IMP
GO:0005886 plasma membrane IEA
GO:0005938 cell cortex IDA
GO:0010008 endosome membrane IEA
GO:0030479 actin cortical patch IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 2.94e-56 3.82e-107
GO:0005634 nucleus GO:0005938 cell cortex 8.51e-06 1.01e-06
GO:0005634 nucleus GO:0010008 endosome membrane 2.09e-05 2.97e-02
Interactor Also a MoonDB EMF protein
IOC2_YEAST No
RV167_YEAST Yes: P39743 (MoonDB)
MYO5_YEAST Yes: Q04439 (MoonDB)
KPC1_YEAST No
MMS4_YEAST No
SEN1_YEAST No
MLP1_YEAST No
BSP1_YEAST No
CSR2_YEAST No
BOS1_YEAST No
HSE1_YEAST No
SWC3_YEAST No
KTR3_YEAST No
RBD2_YEAST No
RLA4_YEAST No
ABP1_YEAST No
ACK1_YEAST No
AIM21_YEAST No
AIM3_YEAST No
ALG10_YEAST No
AP2A_YEAST No
AP2_YEAST No
APP1_YEAST No
ATM_YEAST No
ATR1_YEAST No
ATR_YEAST No
CAP_YEAST No
CBK1_YEAST No
CLG1_YEAST No
COPE_YEAST No
COQ2_YEAST No
CSE1_YEAST No
DEF1_YEAST No
DMA2_YEAST No
DUR3_YEAST No
ECM25_YEAST No
EDE1_YEAST No
EMC1_YEAST No
ENT2_YEAST No
ERF3_YEAST No
FDH1_YEAST No
GAA1_YEAST No
GAL83_YEAST No
GMH1_YEAST No
GTS1_YEAST No
HAP2_YEAST No
HMDH1_YEAST No
HUA1_YEAST No
HUA2_YEAST No
IMB4_YEAST No
INN1_YEAST No
INP52_YEAST No
INP53_YEAST No
IOC3_YEAST No
KRE6_YEAST No
LAS17_YEAST No
LDB17_YEAST No
LDB19_YEAST No
LSB3_YEAST No
LSB5_YEAST No
MCM6_YEAST No
MDN1_YEAST No
MGA2_YEAST No
MGM1_YEAST No
MIG1_YEAST No
MPS1_YEAST No
MTH1_YEAST No
MUD2_YEAST No
NDC80_YEAST No
NDOR1_YEAST No
NHP10_YEAST No
NKP2_YEAST No
NTR2_YEAST No
PER33_YEAST No
PFKA1_YEAST No
PP12_YEAST No
PRK1_YEAST No
RAD1_YEAST No
RRP12_YEAST No
RRP7_YEAST No
SCD5_YEAST No
SCM3_YEAST No
SFH5_YEAST No
SHO1_YEAST No
SMA1_YEAST No
SNA3_YEAST No
SPO23_YEAST No
SPO75_YEAST No
STD1_YEAST No
STP22_YEAST No
SYDC_YEAST No
SYP1_YEAST No
SYS1_YEAST No
TBS1_YEAST No
TDA7_YEAST No
TGL3_YEAST No
TGS1_YEAST No
UBP3_YEAST No
UBP7_YEAST No
URC2_YEAST No
URE2_YEAST No
VPS73_YEAST No
VPS9_YEAST No
VTH1_YEAST No
WWM1_YEAST No
YAP7_YEAST No
YCZ0_YEAST No
YD206_YEAST No
YD271_YEAST No
YJ85_YEAST No
YL363_YEAST No
YM24_YEAST No
YM87_YEAST No
YN25_YEAST No
YNO4_YEAST No
YSC84_YEAST No
ZDS2_YEAST Yes: P54786 (MoonDB)
PMID Article Title
1441753 Sequence of a 12.7 kb segment of yeast chromosome II identifies a PDR-like gene and several new open reading frames.
7813418 Complete DNA sequence of yeast chromosome II.
8335689 Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae.
8756649 The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae.
9008707 A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection.
9024694 Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton.
9128251 High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.
10198057 Sla1p is a functionally modular component of the yeast cortical actin cytoskeleton required for correct localization of both Rho1p-GTPase and Sla2p, a protein with talin homology.
10594004 Pan1p, End3p, and Sla1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis.
11739778 Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p.
11940605 Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.
11950888 Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics.
12237851 Actin patch assembly proteins Las17p and Sla1p restrict cell wall growth to daughter cells and interact with cis-Golgi protein Kre6p.
12388763 Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae.
12734398 An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast.
12814545 Negative regulation of yeast WASp by two SH3 domain-containing proteins.
14562095 Global analysis of protein localization in budding yeast.
14562106 Global analysis of protein expression in yeast.
14761940 The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.
15265985 The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p.
15525671 Actin and septin ultrastructures at the budding yeast cell cortex.
15651983 Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes.
17286805 Nucleocytoplasmic trafficking is required for functioning of the adaptor protein Sla1p in endocytosis.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
17363896 Structure of Sla1p homology domain 1 and interaction with the NPFxD endocytic internalization motif.
17765920 Structural basis for ubiquitin recognition by SH3 domains.
17978096 A novel function of Arp2p in mediating Prk1p-specific regulation of actin and endocytosis in yeast.
18407956 A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
22106047 Sites of ubiquitin attachment in Saccharomyces cerevisiae.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
SHD1 IPR007131 InterPro
Sla1 IPR029922 InterPro
Sla1_SH3_1 IPR035800 InterPro
Sla1_SH3_3 IPR035821 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH3_1 PF00018 Pfam
SHD1 PF03983 Pfam
SH3_9 PF14604 Pfam
SH3DOMAIN PR00452 PRINTS
SH3 PS50002 PROSITE
PTHR11216:SF55 PTHR11216:SF55 PANTHER
S25327 S25327 PIR
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SH3_Sla1p_1 cd11773 CDD
SH3_Sla1p_3 cd11775 CDD