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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P30822
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P30822 (Uniprot)
XPO1_YEAST
CRM1
Exportin-1
yeast
No
Protein Function
Uniprot:
Receptor for the leucine-rich nuclear export signal (NES).
MoonDB Dissimilar Functions
Showing 1 to 3 of 3 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0008104
protein localization
1184
GO:0044260
cellular macromolecule metabolic process
1268
,
1269
7.50e-19
5.37e-13
GO:0044260
cellular macromolecule metabolic process
901
,
989
GO:0033036
macromolecule localization
1156
1.18e-20
4.59e-11
GO:0044260
cellular macromolecule metabolic process
901
,
989
GO:0070727
cellular macromolecule localization
1184
2.61e-07
8.40e-04
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 23 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
901
GO:0016070
RNA metabolic process
901
GO:0010467
gene expression
904
GO:0010467
gene expression
964
GO:0006397
mRNA processing
964
GO:0000956
nuclear-transcribed mRNA catabolic process
964
GO:0022613
ribonucleoprotein complex biogenesis
989
GO:0016070
RNA metabolic process
989
GO:0010467
gene expression
990
GO:0006464
cellular protein modification process
1004
GO:0090304
nucleic acid metabolic process
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Cellular Components
Showing 1 to 10 of 25 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
901
GO:0005634
nucleus
903
GO:0005634
nucleus
904
GO:0005634
nucleus
914
GO:0043232
intracellular non-membrane-bounded organelle
964
GO:0000932
P-body
964
GO:0005634
nucleus
989
GO:0005634
nucleus
990
GO:0005634
nucleus
1004
GO:0005634
nucleus
1016
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 6 of 6 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000055
ribosomal large subunit export from nucleus
IMP
GO:0000056
ribosomal small subunit export from nucleus
IBA
GO:0006406
mRNA export from nucleus
IMP
GO:0006611
protein export from nucleus
IMP
GO:0034501
protein localization to kinetochore
IGI
GO:0046825
regulation of protein export from nucleus
IBA
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000776
kinetochore
IDA
GO:0005634
nucleus
IDA
GO:0005737
cytoplasm
IBA
GO:0005816
spindle pole body
IDA
GO:0048471
perinuclear region of cytoplasm
IEA
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Dissimilar Cellular Components (PrOnto)
Showing 1 to 2 of 2 entries
Search:
GO ID 1
Component 1
GO ID 2
Component 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0000776
kinetochore
GO:0005737
cytoplasm
3.18e-02
1.76e-05
GO:0005634
nucleus
GO:0005737
cytoplasm
5.14e-51
7.30e-86
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All Protein Interactions
Showing 1 to 10 of 60 entries
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Interactor
Also a MoonDB EMF protein
ACE2_YEAST
No
ACF4_YEAST
No
AP1_YEAST
No
BECN1_YEAST
No
CTL1_YEAST
No
DAD1_YEAST
No
DCP1_YEAST
No
DCP2_YEAST
No
ECM30_YEAST
No
EDC3_YEAST
No
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Publications Associated
Showing 1 to 10 of 11 entries
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PMID
Article Title
1448080
Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.
8701610
Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII.
9169869
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
9323132
Exportin 1 (Crm1p) is an essential nuclear export factor.
14562095
Global analysis of protein localization in budding yeast.
14562106
Global analysis of protein expression in yeast.
15020406
The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing.
15769879
Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.
18407956
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 13 entries
Search:
Domain Name
Domain ID
Source
ARM-like
IPR011989
InterPro
ARM-type_fold
IPR016024
InterPro
CRM1_C
PF08767
Pfam
CRM1_C
SM01102
SMART
CRM1_C_dom
IPR014877
InterPro
Exportin-1/Importin-b-like
IPR013598
InterPro
IBN_N
PF03810
Pfam
IBN_N
SM00913
SMART
Importin-beta_N
IPR001494
InterPro
IMPORTIN_B_NT
PS50166
PROSITE
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