Protein: P17931

Uniprot: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. more..

Function 1: Transcription factor. Plays a crucial role in the regulation of specific gene expression dependent on a cell type through the interaction with various transcription factor and phosphorylation is required for exerting its activity. Acts as a pre-mRNA splicing factor. Condition: nuclear localisation.

Function 2: Extracellular Gal-3 mediates cell migration, cell adhesion, and cell-cell interactions through its carbohydrate-binding property, whereas cytoplasmic Gal-3 exerts anti-apoptotic activity and modulates several signal transduction pathways. Condition: cytoplasmic or extracellular localisation (secreted by a non-classical secretory pathway and associates with the cell surface).

Publications (PMID): 17318396, 17726578, 15326483

Module ID (MoonGO) GO ID (BP) GO Name
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002548 monocyte chemotaxis IDA
GO:0006397 mRNA processing IEA
GO:0008380 RNA splicing IEA
GO:0030593 neutrophil chemotaxis IDA
GO:0030855 epithelial cell differentiation IEP
GO:0042129 regulation of T cell proliferation IMP
GO:0043312 neutrophil degranulation TAS
GO:0045087 innate immune response IEA
GO:0045637 regulation of myeloid cell differentiation TAS
GO:0045806 negative regulation of endocytosis IDA
GO:0048245 eosinophil chemotaxis IDA
GO:0048246 macrophage chemotaxis IDA
GO:0050860 negative regulation of T cell receptor signaling pathway ISS
GO:0050918 positive chemotaxis IDA
GO:0070232 regulation of T cell apoptotic process IDA
GO:0071674 mononuclear cell migration IDA
GO:0071677 positive regulation of mononuclear cell migration IDA
GO:0090280 positive regulation of calcium ion import IDA
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
GO:2000521 negative regulation of immunological synapse formation ISS
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISS
GO:2001200 positive regulation of dendritic cell differentiation IDA
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001772 immunological synapse IDA
GO:0005576 extracellular region IDA
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005681 spliceosomal complex IEA
GO:0005737 cytoplasm IDA
GO:0005743 mitochondrial inner membrane IDA
GO:0005886 plasma membrane TAS
GO:0016020 membrane IDA
GO:0030667 secretory granule membrane TAS
GO:0031012 extracellular matrix IDA
GO:0070062 extracellular exosome IDA
GO:0101003 ficolin-1-rich granule membrane TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030667 secretory granule membrane 2.55e-12 1.97e-91
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005681 spliceosomal complex GO:0005886 plasma membrane 3.11e-19 7.74e-95
GO:0005681 spliceosomal complex GO:0016020 membrane 6.04e-13 3.30e-19
PMID Article Title
2009535 Molecular cloning and chromosomal mapping of a human galactoside-binding protein.
2022338 Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
2261464 Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
2402511 Molecular cloning of a human macrophage lectin specific for galactose.
7682704 Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.
8253806 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
9439577 The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.
9501082 Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.
9582341 X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
12508121 The DNA sequence and analysis of human chromosome 14.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15181153 NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19497882 A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.
19594635 The regulation of inflammation by galectin-3.
19616076 Dynamics of galectin-3 in the nucleus and cytoplasm.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24945728 Modulation of CD6 function through interaction with galectin-1 and -3.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
A35820 A35820 PIR
Galectin_CRD IPR001079 InterPro
ConA-like_dom_sf IPR013320 InterPro
Galectin_3 IPR015534 InterPro
Gal-bind_lectin PF00337 Pfam
Gal-bind_lectin SM00908 SMART
SSF49899 SSF49899 SUPFAM
GLECT cd00070 CDD