Protein: P17931

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P17931 (Uniprot) LEG3_HUMAN LGALS3 Galectin-3 human Yes
Uniprot: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. more..
Dissimilar Functions Manual Curation

Function 1: Transcription factor. Plays a crucial role in the regulation of specific gene expression dependent on a cell type through the interaction with various transcription factor and phosphorylation is required for exerting its activity. Acts as a pre-mRNA splicing factor. Condition: nuclear localisation.

Function 2: Extracellular Gal-3 mediates cell migration, cell adhesion, and cell-cell interactions through its carbohydrate-binding property, whereas cytoplasmic Gal-3 exerts anti-apoptotic activity and modulates several signal transduction pathways. Condition: cytoplasmic or extracellular localisation (secreted by a non-classical secretory pathway and associates with the cell surface).

Publications (PMID): 17318396, 17726578, 15326483

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002548 monocyte chemotaxis IDA
GO:0006397 mRNA processing IEA
GO:0008380 RNA splicing IEA
GO:0030593 neutrophil chemotaxis IDA
GO:0030855 epithelial cell differentiation IEP
GO:0042129 regulation of T cell proliferation IMP
GO:0043312 neutrophil degranulation TAS
GO:0045087 innate immune response IEA
GO:0045637 regulation of myeloid cell differentiation TAS
GO:0045806 negative regulation of endocytosis IDA
GO:0048245 eosinophil chemotaxis IDA
GO:0048246 macrophage chemotaxis IDA
GO:0050860 negative regulation of T cell receptor signaling pathway ISS
GO:0050918 positive chemotaxis IDA
GO:0070232 regulation of T cell apoptotic process IDA
GO:0071674 mononuclear cell migration IDA
GO:0071677 positive regulation of mononuclear cell migration IDA
GO:0090280 positive regulation of calcium ion import IDA
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
GO:2000521 negative regulation of immunological synapse formation ISS
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISS
GO:2001200 positive regulation of dendritic cell differentiation IDA
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001772 immunological synapse IDA
GO:0005576 extracellular region IDA
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005681 spliceosomal complex IEA
GO:0005737 cytoplasm IDA
GO:0005743 mitochondrial inner membrane IDA
GO:0005886 plasma membrane TAS
GO:0016020 membrane IDA
GO:0030667 secretory granule membrane TAS
GO:0031012 extracellular matrix IDA
GO:0070062 extracellular exosome IDA
GO:0101003 ficolin-1-rich granule membrane TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030667 secretory granule membrane 2.55e-12 1.97e-91
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005681 spliceosomal complex GO:0005886 plasma membrane 3.11e-19 7.74e-95
GO:0005681 spliceosomal complex GO:0016020 membrane 6.04e-13 3.30e-19
PMID Article Title
2009535 Molecular cloning and chromosomal mapping of a human galactoside-binding protein.
2022338 Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
2261464 Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
2402511 Molecular cloning of a human macrophage lectin specific for galactose.
7682704 Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.
8253806 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
9439577 The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.
9501082 Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.
9582341 X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
12508121 The DNA sequence and analysis of human chromosome 14.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15181153 NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19497882 A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.
19594635 The regulation of inflammation by galectin-3.
19616076 Dynamics of galectin-3 in the nucleus and cytoplasm.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24945728 Modulation of CD6 function through interaction with galectin-1 and -3.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
A35820 A35820 PIR
Galectin_CRD IPR001079 InterPro
ConA-like_dom_sf IPR013320 InterPro
Galectin_3 IPR015534 InterPro
Gal-bind_lectin PF00337 Pfam
GALECTIN PS51304 PROSITE
PTHR11346:SF26 PTHR11346:SF26 PANTHER
GLECT SM00276 SMART
Gal-bind_lectin SM00908 SMART
SSF49899 SSF49899 SUPFAM
GLECT cd00070 CDD