Function 1: Transcription factor. Plays a crucial role in the regulation of specific gene expression dependent on a cell type through the interaction with various transcription factor and phosphorylation is required for exerting its activity. Acts as a pre-mRNA splicing factor. Condition: nuclear localisation.
Function 2: Extracellular Gal-3 mediates cell migration, cell adhesion, and cell-cell interactions through its carbohydrate-binding property, whereas cytoplasmic Gal-3 exerts anti-apoptotic activity and modulates several signal transduction pathways. Condition: cytoplasmic or extracellular localisation (secreted by a non-classical secretory pathway and associates with the cell surface).
Publications (PMID): 17318396, 17726578, 15326483