Protein: P17931 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P17931 (Uniprot)	LEG3_HUMAN	LGALS3	Galectin-3	human	Yes

Protein Function

Uniprot: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA s more..

Dissimilar Functions Manual Curation

Function 1: Transcription factor. Plays a crucial role in the regulation of specific gene expression dependent on a cell type through the interaction with various transcription factor and phosphorylation is required for exerting its activity. Acts as a pre-mRNA splicing factor. Condition: nuclear localisation.

Function 2: Extracellular Gal-3 mediates cell migration, cell adhesion, and cell-cell interactions through its carbohydrate-binding property, whereas cytoplasmic Gal-3 exerts anti-apoptotic activity and modulates several signal transduction pathways. Condition: cytoplasmic or extracellular localisation (secreted by a non-classical secretory pathway and associates with the cell surface).

Publications (PMID): 17318396, 17726578, 15326483

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
464	GO:0016070	RNA metabolic process
464	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus
464	GO:0070013	intracellular organelle lumen
464	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002548	monocyte chemotaxis	IDA
GO:0006397	mRNA processing	IEA
GO:0008380	RNA splicing	IEA
GO:0030593	neutrophil chemotaxis	IDA
GO:0030855	epithelial cell differentiation	IEP
GO:0042129	regulation of T cell proliferation	IMP
GO:0043312	neutrophil degranulation	TAS
GO:0045087	innate immune response	IEA
GO:0045637	regulation of myeloid cell differentiation	TAS
GO:0045806	negative regulation of endocytosis	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0001772	immunological synapse	IDA
GO:0005576	extracellular region	IDA
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	IDA
GO:0005681	spliceosomal complex	IEA
GO:0005737	cytoplasm	IDA
GO:0005743	mitochondrial inner membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0016020	membrane	IDA
GO:0030667	secretory granule membrane	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0030667	secretory granule membrane	2.55e-12	1.97e-91
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005681	spliceosomal complex	GO:0005886	plasma membrane	3.11e-19	7.74e-95
GO:0005681	spliceosomal complex	GO:0016020	membrane	6.04e-13	3.30e-19

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BARD1_HUMAN	No
CD166_HUMAN	No
CD6_HUMAN	No
CREST_HUMAN	No
CRX_HUMAN	No
GOGA2_HUMAN	Yes: Q08379 (MoonDB)
INCA1_HUMAN	No
KI16B_HUMAN	No
MYOC_HUMAN	No
PAXI1_HUMAN	No

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Publications Associated

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PMID	Article Title
2009535	Molecular cloning and chromosomal mapping of a human galactoside-binding protein.
2022338	Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
2261464	Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
2402511	Molecular cloning of a human macrophage lectin specific for galactose.
7682704	Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.
8253806	L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
9439577	The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.
9501082	Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.
9582341	X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
12508121	The DNA sequence and analysis of human chromosome 14.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A35820	A35820	PIR
ConA-like_dom_sf	IPR013320	InterPro
Gal-bind_lectin	PF00337	Pfam
Gal-bind_lectin	SM00908	SMART
GALECTIN	PS51304	PROSITE
Galectin_3	IPR015534	InterPro
Galectin_CRD	IPR001079	InterPro
GLECT	SM00276	SMART
GLECT	cd00070	CDD
PTHR11346:SF26	PTHR11346:SF26	PANTHER

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