Protein: Q9NQX1

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NQX1 (Uniprot) PRDM5_HUMAN PRDM5 PR domain zinc finger protein 5 human No
Uniprot: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294 GO:0019538 protein metabolic process 552 1.88e-02 4.66e-37
Module ID (MoonGO) GO ID (BP) GO Name
294 GO:0000398 mRNA splicing, via spliceosome
552 GO:0044267 cellular protein metabolic process
554 GO:0016070 RNA metabolic process
554 GO:0010468 regulation of gene expression
Module ID (MoonGO) GO ID (CC) GO Name
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
552 GO:0005634 nucleus
554 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0000278 mitotic cell cycle IMP
GO:0006351 transcription, DNA-templated IEA
GO:0016575 histone deacetylation IMP
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0051567 histone H3-K9 methylation IDA
GO:1990830 cellular response to leukemia inhibitory factor IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005730 nucleolus IDA
GO:0016604 nuclear body IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15077163 PRDM5 is silenced in human cancers and has growth suppressive activities.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17636019 Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.
17699856 PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.
21664999 Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance.
OMIM ID Disease Name
614170 Brittle cornea syndrome 2
Domain Name Domain ID Source
SET_dom IPR001214 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_C2H2_type IPR013087 InterPro
Znf_PRDM5-like IPR017125 InterPro
Znf_C2H2_sf IPR036236 InterPro
ZnF_C2H2 SM00355 SMART
SSF57667 SSF57667 SUPFAM