Protein: Q9NQX1 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NQX1 (Uniprot)	PRDM5_HUMAN	PRDM5	PR domain zinc finger protein 5	human	No

Protein Function

Uniprot: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins invol more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294	GO:0019538	protein metabolic process	552	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
294	GO:0000398	mRNA splicing, via spliceosome
552	GO:0044267	cellular protein metabolic process
554	GO:0016070	RNA metabolic process
554	GO:0010468	regulation of gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
294	GO:0030529	intracellular ribonucleoprotein complex
294	GO:0005654	nucleoplasm
552	GO:0005634	nucleus
554	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0000278	mitotic cell cycle	IMP
GO:0006351	transcription, DNA-templated	IEA
GO:0016575	histone deacetylation	IMP
GO:0045892	negative regulation of transcription, DNA-templated	IDA
GO:0051567	histone H3-K9 methylation	IDA
GO:1990830	cellular response to leukemia inhibitory factor	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IDA
GO:0016604	nuclear body	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ARHL2_HUMAN	No
CLCN1_HUMAN	No
FAP20_HUMAN	No
FBX44_HUMAN	No
RASD1_HUMAN	No
TFAP4_HUMAN	No
TYK2_HUMAN	No
VIPR1_HUMAN	No

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Publications Associated

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PMID	Article Title
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15077163	PRDM5 is silenced in human cancers and has growth suppressive activities.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17636019	Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.
17699856	PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.
21664999	Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614170	Brittle cornea syndrome 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
PRDM	PIRSF037162	PIRSF
SET	PS50280	PROSITE
SET	SM00317	SMART
SET_dom	IPR001214	InterPro
SSF57667	SSF57667	SUPFAM
ZINC_FINGER_C2H2_1	PS00028	PROSITE
ZINC_FINGER_C2H2_2	PS50157	PROSITE
ZnF_C2H2	SM00355	SMART
Znf_C2H2_sf	IPR036236	InterPro
Znf_C2H2_type	IPR013087	InterPro

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