Protein: Q9H190 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9H190 (Uniprot)	SDCB2_HUMAN	SDCBP2	Syntenin-2	human	No

Protein Function

Uniprot: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0016070	RNA metabolic process	689	GO:0036211	protein modification process	695	5.81e-04	8.44e-05
GO:0019538	protein metabolic process	56	GO:0016070	RNA metabolic process	689	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
47	GO:0044271	cellular nitrogen compound biosynthetic process
47	GO:0051252	regulation of RNA metabolic process
47	GO:0010468	regulation of gene expression
56	GO:0044267	cellular protein metabolic process
56	GO:0060255	regulation of macromolecule metabolic process
96	GO:0016070	RNA metabolic process
96	GO:0010467	gene expression
340	GO:0016070	RNA metabolic process
340	GO:0010467	gene expression
340	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
47	GO:0005654	nucleoplasm
56	GO:0005829	cytosol
96	GO:0005654	nucleoplasm
117	GO:0005634	nucleus
322	GO:0005634	nucleus
340	GO:0005634	nucleus
530	GO:0070013	intracellular organelle lumen
530	GO:0005634	nucleus
548	GO:0070013	intracellular organelle lumen
548	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007399	nervous system development	NAS
GO:0008283	cell proliferation	IMP
GO:0035556	intracellular signal transduction	NAS
GO:0046907	intracellular transport	NAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005886	plasma membrane	IDA
GO:0016607	nuclear speck	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 3 of 3 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07
GO:0005886	plasma membrane	GO:0016607	nuclear speck	2.37e-16	9.27e-101
GO:0016607	nuclear speck	GO:0070062	extracellular exosome	7.04e-04	3.03e-123

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All Protein Interactions

Showing 1 to 10 of 62 entries

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Interactor	Also a MoonDB EMF protein
A0A024RA76_HUMAN	No
ADAP1_HUMAN	No
AK17A_HUMAN	No
AP1M1_HUMAN	No
ARF4_HUMAN	No
BEND7_HUMAN	No
CA097_HUMAN	No
CGL_HUMAN	No
CHCH1_HUMAN	No
CK057_HUMAN	No

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Publications Associated

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PMID	Article Title
11102519	The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.
11152476	The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.
11780052	The DNA sequence and comparative analysis of human chromosome 20.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15961997	Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions.
16959974	The consensus coding sequences of human breast and colorectal cancers.
22623796	Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2.
23300061	The characterization of the nuclear dynamics of syntenin-2, a PIP2 binding PDZ protein.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
PDZ	IPR001478	InterPro
PDZ	PF00595	Pfam
PDZ	PS50106	PROSITE
PDZ	SM00228	SMART
PDZ_sf	IPR036034	InterPro
SSF50156	SSF50156	SUPFAM

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