Protein: P98175

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P98175 (Uniprot) RBM10_HUMAN RBM10 RNA-binding protein 10 human No
Uniprot: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006396 RNA processing 426 GO:0036211 protein modification process 440, 555 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
31 GO:0034645 cellular macromolecule biosynthetic process
31 GO:0044271 cellular nitrogen compound biosynthetic process
31 GO:0090304 nucleic acid metabolic process
31 GO:0010468 regulation of gene expression
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
353 GO:0000398 mRNA splicing, via spliceosome
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
458 GO:0006139 nucleobase-containing compound metabolic process
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
649 GO:0016070 RNA metabolic process
649 GO:0010468 regulation of gene expression
834 GO:0051252 regulation of RNA metabolic process
834 GO:2000112 regulation of cellular macromolecule biosynthetic process
834 GO:0010468 regulation of gene expression
834 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
31 GO:0005634 nucleus
167 GO:0005654 nucleoplasm
191 GO:0031981 nuclear lumen
353 GO:0005654 nucleoplasm
426 GO:0005654 nucleoplasm
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
458 GO:0005634 nucleus
555 GO:0005634 nucleus
649 GO:0070013 intracellular organelle lumen
649 GO:0005634 nucleus
834 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
GO:0006397 mRNA processing IEA
GO:0008150 biological_process ND
GO:0008380 RNA splicing IEA
GO:0042981 regulation of apoptotic process IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0016607 nuclear speck IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8590280 Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
8808293 A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status.
12176931 Large-scale proteomic analysis of the human spliceosome.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15772651 The DNA sequence of the human X chromosome.
16959974 The consensus coding sequences of human breast and colorectal cancers.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17707232 A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
17974005 The full-ORF clone resource of the German cDNA consortium.
18315527 S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20451169 Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
28431233 A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
OMIM ID Disease Name
311900 TARP syndrome
Domain Name Domain ID Source
G_patch_dom IPR000467 InterPro
RRM_dom IPR000504 InterPro
Znf_RanBP2 IPR001876 InterPro
Znf_C2H2_type IPR013087 InterPro
RBM10 IPR033095 InterPro
RBM10_RRM2 IPR034992 InterPro
RBM10_OCRE IPR035618 InterPro
RBD_domain_sf IPR035979 InterPro
Znf_RanBP2_sf IPR036443 InterPro
RRM_1 PF00076 Pfam
zf-RanBP PF00641 Pfam
G-patch PF01585 Pfam
ZF_RANBP2_1 PS01358 PROSITE
RRM PS50102 PROSITE
ZINC_FINGER_C2H2_2 PS50157 PROSITE
G_PATCH PS50174 PROSITE
ZF_RANBP2_2 PS50199 PROSITE
PTHR13948:SF4 PTHR13948:SF4 PANTHER
RRM SM00360 SMART
G_patch SM00443 SMART
ZnF_RBZ SM00547 SMART
SSF54928 SSF54928 SUPFAM
SSF90209 SSF90209 SUPFAM
RRM2_RBM10 cd12754 CDD
OCRE_RBM10 cd16167 CDD