Protein: P55853 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P55853 (Uniprot)	SUMO_CAEEL	smo-1	Small ubiquitin-related modifier	worm	No

Protein Function

Uniprot: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA rep more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	2261	GO:0006139	nucleobase-containing compound metabolic process	2664	1.61e-11	3.68e-10

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MoonDB Network Modules

Biological Processes

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
2261	GO:0044267	cellular protein metabolic process
2664	GO:0090304	nucleic acid metabolic process

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Cellular Components

Showing 1 to 4 of 4 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
2261	GO:0043232	intracellular non-membrane-bounded organelle
2261	GO:0005634	nucleus
2664	GO:0005694	chromosome
2664	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0002119	nematode larval development	IMP
GO:0007080	mitotic metaphase plate congression	IMP
GO:0009792	embryo development ending in birth or egg hatching	IMP
GO:0016925	protein sumoylation	IMP
GO:0034502	protein localization to chromosome	IMP
GO:0051306	mitotic sister chromatid separation	IMP
GO:0070194	synaptonemal complex disassembly	IMP

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IBA
GO:0005694	chromosome	IEA
GO:0005737	cytoplasm	IEA
GO:0005815	microtubule organizing center	IEA
GO:0005819	spindle	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 46 entries

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Interactor	Also a MoonDB EMF protein
A0A131MDC6_CAEEL	No
A5JYT9_CAEEL	No
ADD2_CAEEL	No
BARD1_CAEEL	No
CDK9_CAEEL	No
DYL1_CAEEL	No
DYN1_CAEEL	No
EGL9_CAEEL	No
FAN1_CAEEL	No
FIGL1_CAEEL	No

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Publications Associated

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PMID	Article Title
9119407	SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
9175795	Identification and characterization of the SMT3 cDNA and gene from nematode Caenorhabditis elegans.
9851916	Genome sequence of the nematode C. elegans: a platform for investigating biology.
11806825	Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
15107848	SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
15466489	The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
15689373	Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
15990876	Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
16701625	The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
24285704	Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 10 entries

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Domain Name	Domain ID	Source
JC5582	JC5582	PIR
Rad60-SLD	PF11976	Pfam
Rad60/SUMO-like_dom	IPR022617	InterPro
SSF54236	SSF54236	SUPFAM
Sumo	IPR033950	InterPro
Sumo	cd01763	CDD
Ubiquitin-like_domsf	IPR029071	InterPro
UBIQUITIN_2	PS50053	PROSITE
Ubiquitin_dom	IPR000626	InterPro
UBQ	SM00213	SMART

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