Protein: Q8BH75

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8BH75 (Uniprot) RNF41_MOUSE Rnf41 E3 ubiquitin-protein ligase NRDP1 mouse No
Uniprot: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 1793 GO:0007165 signal transduction 2046 1.18e-123 4.26e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1514 GO:0016070 RNA metabolic process
1514 GO:0010467 gene expression
1550 GO:0006355 regulation of transcription, DNA-templated
1683 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1683 GO:0031325 positive regulation of cellular metabolic process
1683 GO:0010604 positive regulation of macromolecule metabolic process
1683 GO:0051173 positive regulation of nitrogen compound metabolic process
1725 GO:0006796 phosphate-containing compound metabolic process
1793 GO:0044271 cellular nitrogen compound biosynthetic process
1793 GO:0030099 myeloid cell differentiation
1793 GO:2000112 regulation of cellular macromolecule biosynthetic process
1793 GO:0010468 regulation of gene expression
1793 GO:0001932 regulation of protein phosphorylation
1937 GO:0008283 cell proliferation
1937 GO:0022411 cellular component disassembly
1937 GO:0044271 cellular nitrogen compound biosynthetic process
1937 GO:0006464 cellular protein modification process
1937 GO:0051128 regulation of cellular component organization
1937 GO:2000112 regulation of cellular macromolecule biosynthetic process
1937 GO:0032268 regulation of cellular protein metabolic process
1937 GO:0010468 regulation of gene expression
2039 GO:0031324 negative regulation of cellular metabolic process
2039 GO:0006355 regulation of transcription, DNA-templated
2046 GO:0007166 cell surface receptor signaling pathway
2046 GO:0051129 negative regulation of cellular component organization
2046 GO:0045595 regulation of cell differentiation
2046 GO:0030334 regulation of cell migration
2046 GO:0042127 regulation of cell proliferation
2046 GO:2000026 regulation of multicellular organismal development
2046 GO:0051896 regulation of protein kinase B signaling
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1514 GO:0012505 endomembrane system
1514 GO:0031984 organelle subcompartment
1550 GO:0031981 nuclear lumen
1683 GO:0005654 nucleoplasm
2046 GO:0071782 endoplasmic reticulum tubular network
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IDA
GO:0006914 autophagy IEA
GO:0008285 negative regulation of cell proliferation ISO
GO:0010468 regulation of gene expression IDA
GO:0010498 proteasomal protein catabolic process ISO
GO:0016567 protein ubiquitination IDA
GO:0030336 negative regulation of cell migration ISO
GO:0043408 regulation of MAPK cascade ISO
GO:0045619 regulation of lymphocyte differentiation IDA
GO:0045637 regulation of myeloid cell differentiation IDA
GO:0045732 positive regulation of protein catabolic process ISO
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:0051865 protein autoubiquitination ISO
GO:0051896 regulation of protein kinase B signaling ISO
GO:0097191 extrinsic apoptotic signaling pathway ISO
GO:1901525 negative regulation of mitophagy IGI
GO:2000114 regulation of establishment of cell polarity IDA
GO:2000377 regulation of reactive oxygen species metabolic process ISO
GO:2000379 positive regulation of reactive oxygen species metabolic process ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0048471 perinuclear region of cytoplasm ISO
GO:0071782 endoplasmic reticulum tubular network ISO
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072 The transcriptional landscape of the mammalian genome.
17384230 Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3.
18495327 E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic progenitors by governing steady-state levels of cytokine and retinoic acid receptors.
19483718 The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.
24949970 The diabetes susceptibility gene Clec16a regulates mitophagy.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
TRAF-like IPR008974 InterPro
Znf_SIAH IPR013010 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
NRDP1 IPR015036 InterPro
Znf_RING_CS IPR017907 InterPro
NRDP1_C IPR037255 InterPro
USP8_interact PF08941 Pfam
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_SIAH PS51081 PROSITE
RING SM00184 SMART
SSF160088 SSF160088 SUPFAM
SSF49599 SSF49599 SUPFAM