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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q6PDN3
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q6PDN3 (Uniprot)
MYLK_MOUSE
Mylk
Myosin light chain kinase, smooth muscle
mouse
No
Protein Function
Uniprot:
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apo
ptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006355
regulation of transcription, DNA-templated
1677
GO:0022610
biological adhesion
2014
4.83e-02
3.44e-15
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 40 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1431
GO:0060255
regulation of macromolecule metabolic process
1507
GO:0070887
cellular response to chemical stimulus
1507
GO:0060255
regulation of macromolecule metabolic process
1523
GO:0006355
regulation of transcription, DNA-templated
1621
GO:0016477
cell migration
1621
GO:0044267
cellular protein metabolic process
1621
GO:0070887
cellular response to chemical stimulus
1621
GO:0120036
plasma membrane bounded cell projection organization
1621
GO:0051336
regulation of hydrolase activity
1626
GO:0031328
positive regulation of cellular biosynthetic process
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Cellular Components
Showing 1 to 10 of 25 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1431
GO:0044428
nuclear part
1523
GO:0005634
nucleus
1602
GO:0031982
vesicle
1621
GO:0030054
cell junction
1621
GO:0009986
cell surface
1621
GO:0070062
extracellular exosome
1621
GO:0030027
lamellipodium
1626
GO:0044428
nuclear part
1677
GO:0031981
nuclear lumen
1749
GO:0044430
cytoskeletal part
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 12 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006468
protein phosphorylation
IEA
GO:0006939
smooth muscle contraction
IMP
GO:0014820
tonic smooth muscle contraction
IMP
GO:0030335
positive regulation of cell migration
ISO
GO:0032060
bleb assembly
ISO
GO:0035690
cellular response to drug
IDA
GO:0035865
cellular response to potassium ion
IDA
GO:0051928
positive regulation of calcium ion transport
ISO
GO:0060414
aorta smooth muscle tissue morphogenesis
ISO
GO:0071277
cellular response to calcium ion
IDA
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Cellular Components
Showing 1 to 6 of 6 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0001725
stress fiber
ISO
GO:0005737
cytoplasm
ISO
GO:0005911
cell-cell junction
IDA
GO:0030027
lamellipodium
ISO
GO:0032154
cleavage furrow
ISO
GO:0070062
extracellular exosome
ISO
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 19 entries
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Interactor
Also a MoonDB EMF protein
B2RR24_MOUSE
No
CAVN1_MOUSE
No
CDT1_MOUSE
No
FLNB_MOUSE
No
HNRPL_MOUSE
No
MYCN_MOUSE
No
PABP2_MOUSE
No
PTBP2_MOUSE
No
Q6P6L5_MOUSE
No
Q9JMG9_MOUSE
No
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Publications Associated
Showing 1 to 10 of 18 entries
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PMID
Article Title
11029314
Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.
11121372
Telokin expression is restricted to smooth muscle tissues during mouse development.
11472067
The myosin light chain kinase gene is not duplicated in mouse: partial structure and chromosomal localization of Mylk.
11832329
220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns.
12360480
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16055522
Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function.
16141072
The transcriptional landscape of the mammalian genome.
16184195
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
17242355
Large-scale phosphorylation analysis of mouse liver.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 30 entries
Search:
Domain Name
Domain ID
Source
fn3
PF00041
Pfam
FN3
PS50853
PROSITE
FN3
SM00060
SMART
FN3
cd00063
CDD
FN3_dom
IPR003961
InterPro
FN3_sf
IPR036116
InterPro
I-set
PF07679
Pfam
IG
SM00409
SMART
Ig-like_dom
IPR007110
InterPro
Ig-like_dom_sf
IPR036179
InterPro
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