Protein: Q14457 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q14457 (Uniprot)	BECN1_HUMAN	BECN1	Beclin-1	human	No

Protein Function

Uniprot: Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophag more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006793	phosphorus metabolic process	491	GO:0009059	macromolecule biosynthetic process	6	1.25e-35	4.53e-23

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
6	GO:0034645	cellular macromolecule biosynthetic process
6	GO:0010467	gene expression
6	GO:0090304	nucleic acid metabolic process
6	GO:0060255	regulation of macromolecule metabolic process
257	GO:0044267	cellular protein metabolic process
257	GO:0007165	signal transduction
451	GO:0007165	signal transduction
451	GO:0016192	vesicle-mediated transport
491	GO:0006796	phosphate-containing compound metabolic process
565	GO:0008283	cell proliferation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
6	GO:0043232	intracellular non-membrane-bounded organelle
6	GO:0005654	nucleoplasm
257	GO:0031982	vesicle
451	GO:0005829	cytosol
451	GO:0012505	endomembrane system
451	GO:0005634	nucleus
491	GO:0005829	cytosol
491	GO:0043232	intracellular non-membrane-bounded organelle
491	GO:0005634	nucleus
556	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000045	autophagosome assembly	IBA
GO:0000422	autophagy of mitochondrion	IMP
GO:0000423	mitophagy	IMP
GO:0000910	cytokinesis	IMP
GO:0001666	response to hypoxia	IEA
GO:0006914	autophagy	IMP
GO:0006915	apoptotic process	IEA
GO:0006968	cellular defense response	TAS
GO:0006995	cellular response to nitrogen starvation	IBA
GO:0007040	lysosome organization	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000407	pre-autophagosomal structure	IBA
GO:0005634	nucleus	IEA
GO:0005739	mitochondrion	IMP
GO:0005768	endosome	IDA
GO:0005776	autophagosome	IEA
GO:0005783	endoplasmic reticulum	IDA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005802	trans-Golgi network	IEA
GO:0005829	cytosol	TAS
GO:0010008	endosome membrane	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0005789	endoplasmic reticulum membrane	1.61e-25	3.10e-56
GO:0005634	nucleus	GO:0005802	trans-Golgi network	6.33e-05	3.57e-57
GO:0005634	nucleus	GO:0010008	endosome membrane	1.38e-08	8.40e-30
GO:0005634	nucleus	GO:0031966	mitochondrial membrane	7.12e-06	7.29e-05
GO:0005789	endoplasmic reticulum membrane	GO:0005829	cytosol	4.27e-12	7.53e-04

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AMRA1_HUMAN	No
ATX3_HUMAN	No
B2CL1_HUMAN	No
BAK_HUMAN	No
BAKOR_HUMAN	No
BCL2_HUMAN	No
BTK_HUMAN	No
D6PAV9_HUMAN	No
DAPK1_HUMAN	No
DESP_HUMAN	No

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Publications Associated

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PMID	Article Title
7490091	Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.
9765397	Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
10395800	Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16179260	Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
17337444	Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.
17446862	Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.
17659302	Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1.
17724469	Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
APG6	PF04111	Pfam
Atg6/Beclin	IPR007243	InterPro
BECN1	IPR032913	InterPro
BH3	PF15285	Pfam
BH3_dom	IPR029318	InterPro
I54209	I54209	PIR
PTHR12768	PTHR12768	PANTHER
PTHR12768:SF6	PTHR12768:SF6	PANTHER

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