Protein: Q14457

Uniprot: Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006793 phosphorus metabolic process 491 GO:0009059 macromolecule biosynthetic process 6 1.25e-35 4.53e-23
Module ID (MoonGO) GO ID (BP) GO Name
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
257 GO:0044267 cellular protein metabolic process
257 GO:0007165 signal transduction
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
491 GO:0006796 phosphate-containing compound metabolic process
565 GO:0008283 cell proliferation
565 GO:0022607 cellular component assembly
565 GO:0071310 cellular response to organic substance
565 GO:0097191 extrinsic apoptotic signaling pathway
565 GO:0010467 gene expression
565 GO:0043066 negative regulation of apoptotic process
565 GO:0032270 positive regulation of cellular protein metabolic process
565 GO:0044093 positive regulation of molecular function
565 GO:0009967 positive regulation of signal transduction
565 GO:0006508 proteolysis
565 GO:0050790 regulation of catalytic activity
565 GO:1902531 regulation of intracellular signal transduction
565 GO:1901700 response to oxygen-containing compound
617 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
257 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
491 GO:0005829 cytosol
491 GO:0043232 intracellular non-membrane-bounded organelle
491 GO:0005634 nucleus
556 GO:0005829 cytosol
556 GO:0031982 vesicle
565 GO:0005829 cytosol
565 GO:0005634 nucleus
565 GO:0098805 whole membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000045 autophagosome assembly IBA
GO:0000422 autophagy of mitochondrion IMP
GO:0000423 mitophagy IMP
GO:0000910 cytokinesis IMP
GO:0001666 response to hypoxia IEA
GO:0006914 autophagy IMP
GO:0006915 apoptotic process IEA
GO:0006968 cellular defense response TAS
GO:0006995 cellular response to nitrogen starvation IBA
GO:0007040 lysosome organization IEA
GO:0007080 mitotic metaphase plate congression IMP
GO:0007568 aging IEA
GO:0008285 negative regulation of cell proliferation IEA
GO:0010040 response to iron(II) ion IEA
GO:0010288 response to lead ion IEA
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling NAS
GO:0016032 viral process IEA
GO:0016236 macroautophagy TAS
GO:0016579 protein deubiquitination TAS
GO:0032258 protein localization by the Cvt pathway IBA
GO:0032465 regulation of cytokinesis IMP
GO:0032801 receptor catabolic process IMP
GO:0033197 response to vitamin E IEA
GO:0034198 cellular response to amino acid starvation IEA
GO:0042149 cellular response to glucose starvation ISS
GO:0042493 response to drug IEA
GO:0043066 negative regulation of apoptotic process IEA
GO:0043652 engulfment of apoptotic cell IEA
GO:0044804 autophagy of nucleus IBA
GO:0045022 early endosome to late endosome transport IMP
GO:0045324 late endosome to vacuole transport IBA
GO:0048666 neuron development IEA
GO:0050435 amyloid-beta metabolic process IEA
GO:0050790 regulation of catalytic activity IEA
GO:0051607 defense response to virus IEA
GO:0060548 negative regulation of cell death IMP
GO:0070301 cellular response to hydrogen peroxide IEA
GO:0071275 cellular response to aluminum ion IEA
GO:0071280 cellular response to copper ion IEA
GO:0071364 cellular response to epidermal growth factor stimulus IEA
GO:0098780 response to mitochondrial depolarisation IMP
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore IMP
GO:1905672 negative regulation of lysosome organization IEA
GO:2000378 negative regulation of reactive oxygen species metabolic process IEA
GO:2000786 positive regulation of autophagosome assembly IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000407 pre-autophagosomal structure IBA
GO:0005634 nucleus IEA
GO:0005739 mitochondrion IMP
GO:0005768 endosome IDA
GO:0005776 autophagosome IEA
GO:0005783 endoplasmic reticulum IDA
GO:0005789 endoplasmic reticulum membrane IEA
GO:0005802 trans-Golgi network IEA
GO:0005829 cytosol TAS
GO:0010008 endosome membrane IEA
GO:0019898 extrinsic component of membrane IDA
GO:0030425 dendrite IEA
GO:0031966 mitochondrial membrane IEA
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
GO:0035032 phosphatidylinositol 3-kinase complex, class III ISS
GO:0043234 protein complex IEA
GO:0045335 phagocytic vesicle IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005802 trans-Golgi network 6.33e-05 3.57e-57
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0031966 mitochondrial membrane 7.12e-06 7.29e-05
GO:0005789 endoplasmic reticulum membrane GO:0005829 cytosol 4.27e-12 7.53e-04
PMID Article Title
7490091 Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.
9765397 Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
10395800 Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16179260 Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
17337444 Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.
17446862 Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.
17659302 Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1.
17724469 Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18797192 Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11.
18843052 Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
19050071 Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
19180116 DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.
19270696 Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
19369195 Large-scale proteomics analysis of the human kinome.
19713971 Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL.
20208530 PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
20643123 A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
20819940 Endogenous HMGB1 regulates autophagy.
21364619 Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.
21444671 Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.
21936852 Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.
21962518 Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
22205736 The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1.
22493499 Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23184933 XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23878393 Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
24349490 Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
24443581 Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.
25127057 TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
25275521 Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.
25490155 Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
26263979 RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of beclin-1.
26347139 TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
26783301 Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
28445460 Polyglutamine tracts regulate beclin 1-dependent autophagy.
28479384 Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.
No results found.
Domain Name Domain ID Source
I54209 I54209 PIR
Atg6/Beclin IPR007243 InterPro
BH3_dom IPR029318 InterPro
BECN1 IPR032913 InterPro
APG6 PF04111 Pfam
BH3 PF15285 Pfam