Protein: Q03790

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q03790 (Uniprot) NUP53_YEAST NUP53 Nucleoporin NUP53 yeast No
Uniprot: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 1047 GO:0006810 transport 936 1.51e-114 6.30e-204
Module ID (MoonGO) GO ID (BP) GO Name
936 GO:0071705 nitrogen compound transport
1047 GO:0006139 nucleobase-containing compound metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
911 GO:0012505 endomembrane system
922 GO:0012505 endomembrane system
922 GO:0016021 integral component of membrane
936 GO:0016021 integral component of membrane
936 GO:0031090 organelle membrane
1002 GO:0012505 endomembrane system
1002 GO:0031090 organelle membrane
1047 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006606 protein import into nucleus IGI
GO:0006607 NLS-bearing protein import into nucleus IMP
GO:0006999 nuclear pore organization IGI
GO:0007049 cell cycle IEA
GO:0007088 regulation of mitotic nuclear division IPI
GO:0034501 protein localization to kinetochore IMP
GO:0045893 positive regulation of transcription, DNA-templated IGI
GO:0051028 mRNA transport IEA
GO:0051301 cell division IEA
GO:0060188 regulation of protein desumoylation IPI
GO:0072417 response to spindle checkpoint signaling IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005643 nuclear pore IDA
GO:0031965 nuclear membrane IEA
GO:0044613 nuclear pore central transport channel IDA
GO:0044615 nuclear pore nuclear basket IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9169872 The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9864357 Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.
10684247 The yeast nuclear pore complex: composition, architecture, and transport mechanism.
10688190 A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
11283351 A comprehensive two-hybrid analysis to explore the yeast protein interactome.
11352933 A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.
12403813 Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes.
12473689 The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint.
12604785 Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
12791264 Peering through the pore: nuclear pore complex structure, assembly, and function.
14562106 Global analysis of protein expression in yeast.
14574415 Targets of the cyclin-dependent kinase Cdk1.
14697200 Cell cycle regulated transport controlled by alterations in the nuclear pore complex.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
18407956 A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
RRM_NUP35_dom IPR007846 InterPro
RBD_domain_sf IPR035979 InterPro
Nup35_RRM PF05172 Pfam
S54511 S54511 PIR
SSF54928 SSF54928 SUPFAM