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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q03790
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q03790 (Uniprot)
NUP53_YEAST
NUP53
Nucleoporin NUP53
yeast
No
Protein Function
Uniprot:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by b
oth, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0034641
cellular nitrogen compound metabolic process
1047
GO:0006810
transport
936
1.51e-114
6.30e-204
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MoonDB Network Modules
Biological Processes
Showing 1 to 2 of 2 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
936
GO:0071705
nitrogen compound transport
1047
GO:0006139
nucleobase-containing compound metabolic process
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Cellular Components
Showing 1 to 8 of 8 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
911
GO:0012505
endomembrane system
922
GO:0012505
endomembrane system
922
GO:0016021
integral component of membrane
936
GO:0016021
integral component of membrane
936
GO:0031090
organelle membrane
1002
GO:0012505
endomembrane system
1002
GO:0031090
organelle membrane
1047
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 11 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006606
protein import into nucleus
IGI
GO:0006607
NLS-bearing protein import into nucleus
IMP
GO:0006999
nuclear pore organization
IGI
GO:0007049
cell cycle
IEA
GO:0007088
regulation of mitotic nuclear division
IPI
GO:0034501
protein localization to kinetochore
IMP
GO:0045893
positive regulation of transcription, DNA-templated
IGI
GO:0051028
mRNA transport
IEA
GO:0051301
cell division
IEA
GO:0060188
regulation of protein desumoylation
IPI
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Cellular Components
Showing 1 to 4 of 4 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005643
nuclear pore
IDA
GO:0031965
nuclear membrane
IEA
GO:0044613
nuclear pore central transport channel
IDA
GO:0044615
nuclear pore nuclear basket
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 27 entries
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Interactor
Also a MoonDB EMF protein
ATP14_YEAST
Yes:
Q12349 (MoonDB)
FDFT_YEAST
No
HAP2_YEAST
No
IKS1_YEAST
No
IMB3_YEAST
No
INP54_YEAST
No
LIP1_YEAST
No
NDC1_YEAST
No
NIC96_YEAST
No
NU145_YEAST
No
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Publications Associated
Showing 1 to 10 of 18 entries
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PMID
Article Title
9169872
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9864357
Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.
10684247
The yeast nuclear pore complex: composition, architecture, and transport mechanism.
10688190
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
11283351
A comprehensive two-hybrid analysis to explore the yeast protein interactome.
11352933
A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.
12403813
Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes.
12473689
The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint.
12604785
Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
12791264
Peering through the pore: nuclear pore complex structure, assembly, and function.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 6 of 6 entries
Search:
Domain Name
Domain ID
Source
Nup35_RRM
PF05172
Pfam
RBD_domain_sf
IPR035979
InterPro
RRM_NUP35
PS51472
PROSITE
RRM_NUP35_dom
IPR007846
InterPro
S54511
S54511
PIR
SSF54928
SSF54928
SUPFAM
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