Protein: Q03790 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q03790 (Uniprot)	NUP53_YEAST	NUP53	Nucleoporin NUP53	yeast	No

Protein Function

Uniprot: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by b more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0034641	cellular nitrogen compound metabolic process	1047	GO:0006810	transport	936	1.51e-114	6.30e-204

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MoonDB Network Modules

Biological Processes

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
936	GO:0071705	nitrogen compound transport
1047	GO:0006139	nucleobase-containing compound metabolic process

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Cellular Components

Showing 1 to 8 of 8 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
911	GO:0012505	endomembrane system
922	GO:0012505	endomembrane system
922	GO:0016021	integral component of membrane
936	GO:0016021	integral component of membrane
936	GO:0031090	organelle membrane
1002	GO:0012505	endomembrane system
1002	GO:0031090	organelle membrane
1047	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006606	protein import into nucleus	IGI
GO:0006607	NLS-bearing protein import into nucleus	IMP
GO:0006999	nuclear pore organization	IGI
GO:0007049	cell cycle	IEA
GO:0007088	regulation of mitotic nuclear division	IPI
GO:0034501	protein localization to kinetochore	IMP
GO:0045893	positive regulation of transcription, DNA-templated	IGI
GO:0051028	mRNA transport	IEA
GO:0051301	cell division	IEA
GO:0060188	regulation of protein desumoylation	IPI

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005643	nuclear pore	IDA
GO:0031965	nuclear membrane	IEA
GO:0044613	nuclear pore central transport channel	IDA
GO:0044615	nuclear pore nuclear basket	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 27 entries

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Interactor	Also a MoonDB EMF protein
ATP14_YEAST	Yes: Q12349 (MoonDB)
FDFT_YEAST	No
HAP2_YEAST	No
IKS1_YEAST	No
IMB3_YEAST	No
INP54_YEAST	No
LIP1_YEAST	No
NDC1_YEAST	No
NIC96_YEAST	No
NU145_YEAST	No

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Publications Associated

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PMID	Article Title
9169872	The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9864357	Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.
10684247	The yeast nuclear pore complex: composition, architecture, and transport mechanism.
10688190	A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
11283351	A comprehensive two-hybrid analysis to explore the yeast protein interactome.
11352933	A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.
12403813	Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes.
12473689	The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint.
12604785	Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
12791264	Peering through the pore: nuclear pore complex structure, assembly, and function.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
Nup35_RRM	PF05172	Pfam
RBD_domain_sf	IPR035979	InterPro
RRM_NUP35	PS51472	PROSITE
RRM_NUP35_dom	IPR007846	InterPro
S54511	S54511	PIR
SSF54928	SSF54928	SUPFAM

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