Protein: P40054 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P40054 (Uniprot)	SERA_YEAST	SER3	D-3-phosphoglycerate dehydrogenase 1	yeast	No

Protein Function

Uniprot: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	1255	GO:0009059	macromolecule biosynthetic process	921, 1322	3.10e-17	2.99e-04

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
894	GO:0016070	RNA metabolic process
894	GO:0010467	gene expression
921	GO:0034645	cellular macromolecule biosynthetic process
921	GO:0044271	cellular nitrogen compound biosynthetic process
921	GO:0090304	nucleic acid metabolic process
1004	GO:0090304	nucleic acid metabolic process
1014	GO:0034622	cellular macromolecular complex assembly
1014	GO:0006139	nucleobase-containing compound metabolic process
1081	GO:0044267	cellular protein metabolic process
1083	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
894	GO:0044428	nuclear part
921	GO:0005634	nucleus
982	GO:0043232	intracellular non-membrane-bounded organelle
982	GO:0005634	nucleus
1004	GO:0005634	nucleus
1014	GO:0005634	nucleus
1025	GO:0005634	nucleus
1069	GO:0043232	intracellular non-membrane-bounded organelle
1069	GO:0005634	nucleus
1083	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006564	L-serine biosynthetic process	IEA
GO:0009070	serine family amino acid biosynthetic process	IMP
GO:0055114	oxidation-reduction process	IEA

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Cellular Components

No results found.

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 95 entries

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Interactor	Also a MoonDB EMF protein
ABM1_YEAST	No
AGE1_YEAST	No
AGE2_YEAST	No
APTX_YEAST	No
AROG_YEAST	No
ATG14_YEAST	No
ATG22_YEAST	No
BDH1_YEAST	No
BOB1_YEAST	No
CHK1_YEAST	No

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Publications Associated

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PMID	Article Title
9169868	The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
14562106	Global analysis of protein expression in yeast.
18407956	A multidimensional chromatography technology for in-depth phosphoproteome analysis.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.
26774271	Saccharomyces cerevisiae forms D-2-hydroxyglutarate and couples its degradation to D-lactate formation via a cytosolic transhydrogenase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
2-Hacid_dh	PF00389	Pfam
2-Hacid_dh_C	PF02826	Pfam
ACT	PS51671	PROSITE
ACT_dom	IPR002912	InterPro
D-isomer_2_OHA_DH_cat_dom	IPR006139	InterPro
D-isomer_DH_CS	IPR029753	InterPro
D-isomer_DH_CS1	IPR029752	InterPro
D-isomer_DH_NAD-bd	IPR006140	InterPro
D_2_HYDROXYACID_DH_1	PS00065	PROSITE
D_2_HYDROXYACID_DH_2	PS00670	PROSITE

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