Protein: Q6NUS6

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q6NUS6 (Uniprot) TECT3_HUMAN TCTN3 Tectonic-3 human No
Uniprot: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 48 GO:0009059 macromolecule biosynthetic process 672 6.37e-04 1.88e-40
GO:0006139 nucleobase-containing compound metabolic process 189, 452 GO:0007165 signal transduction 828 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
8 GO:0008219 cell death
8 GO:0019538 protein metabolic process
8 GO:0007165 signal transduction
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
128 GO:0007165 signal transduction
189 GO:0090304 nucleic acid metabolic process
257 GO:0044267 cellular protein metabolic process
257 GO:0007165 signal transduction
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
452 GO:0090304 nucleic acid metabolic process
452 GO:0010468 regulation of gene expression
452 GO:0007165 signal transduction
481 GO:0044267 cellular protein metabolic process
481 GO:0007165 signal transduction
537 GO:0060255 regulation of macromolecule metabolic process
537 GO:0007165 signal transduction
621 GO:0006355 regulation of transcription, DNA-templated
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
769 GO:0007165 signal transduction
828 GO:0007166 cell surface receptor signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
8 GO:0012505 endomembrane system
8 GO:0016021 integral component of membrane
14 GO:0031410 cytoplasmic vesicle
14 GO:0005829 cytosol
14 GO:0005783 endoplasmic reticulum
39 GO:0043232 intracellular non-membrane-bounded organelle
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
85 GO:0016021 integral component of membrane
128 GO:0012505 endomembrane system
128 GO:0016021 integral component of membrane
128 GO:0005886 plasma membrane
168 GO:0012505 endomembrane system
168 GO:0016021 integral component of membrane
174 GO:0016021 integral component of membrane
179 GO:0012505 endomembrane system
189 GO:0005634 nucleus
257 GO:0031982 vesicle
264 GO:0012505 endomembrane system
350 GO:0012505 endomembrane system
350 GO:0031224 intrinsic component of membrane
366 GO:0005783 endoplasmic reticulum
366 GO:0016021 integral component of membrane
380 GO:0005634 nucleus
388 GO:0016021 integral component of membrane
389 GO:0012505 endomembrane system
389 GO:0016021 integral component of membrane
431 GO:0005829 cytosol
452 GO:0005829 cytosol
452 GO:0070013 intracellular organelle lumen
452 GO:0044428 nuclear part
481 GO:0005634 nucleus
537 GO:0012505 endomembrane system
600 GO:0005634 nucleus
621 GO:0005634 nucleus
666 GO:0016021 integral component of membrane
672 GO:0031981 nuclear lumen
755 GO:0005829 cytosol
799 GO:0012505 endomembrane system
799 GO:0016021 integral component of membrane
828 GO:0016021 integral component of membrane
828 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process IEA
GO:0007224 smoothened signaling pathway IMP
GO:0043065 positive regulation of apoptotic process IDA
GO:0060271 cilium assembly ISS
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0016021 integral component of membrane IEA
GO:0060170 ciliary membrane TAS
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
Interactor Also a MoonDB EMF protein
JPH1_HUMAN No
DRS7B_HUMAN No
T120B_HUMAN No
1A69_HUMAN No
AAAS_HUMAN No
ABCBA_HUMAN No
ABD12_HUMAN No
ACATN_HUMAN No
ACDSB_HUMAN No
ACOD_HUMAN No
ACSL3_HUMAN No
AL1B1_HUMAN No
AL3A2_HUMAN No
ALG3_HUMAN No
ALG6_HUMAN No
ALG9_HUMAN No
AMRP_HUMAN No
ANKL2_HUMAN No
ANO6_HUMAN No
APOL2_HUMAN No
ASIC1_HUMAN No
AT131_HUMAN No
AT1A1_HUMAN No
AT2A2_HUMAN No
AUP1_HUMAN No
B9D2_HUMAN No
BAP31_HUMAN No
BET1_HUMAN No
BRI3B_HUMAN No
C1QBP_HUMAN No
C2D2A_HUMAN No
CAC1A_HUMAN No
CALR_HUMAN No
CALU_HUMAN No
CALX_HUMAN No
CAMLG_HUMAN No
CC115_HUMAN No
CCD47_HUMAN No
CDKAL_HUMAN No
CDS2_HUMAN No
CERS1_HUMAN No
CERS2_HUMAN No
CGT_HUMAN No
CHPT1_HUMAN No
CISD2_HUMAN No
CKAP4_HUMAN No
CLCC1_HUMAN No
CLCN7_HUMAN No
CLGN_HUMAN No
CLP1L_HUMAN No
CNIH4_HUMAN No
COPE_HUMAN No
CYB5B_HUMAN No
D19L1_HUMAN No
D19L3_HUMAN No
DAD1_HUMAN No
DDX47_HUMAN No
DDX54_HUMAN No
DEGS1_HUMAN No
DEP1B_HUMAN No
DERL1_HUMAN No
DERL2_HUMAN No
DGAT1_HUMAN No
DGKE_HUMAN No
DHB12_HUMAN No
DHCR7_HUMAN No
DHRS7_HUMAN No
DJB11_HUMAN No
DJC10_HUMAN No
DJC11_HUMAN No
DJC16_HUMAN No
DNJC1_HUMAN No
DNJC3_HUMAN No
DOPP1_HUMAN No
E2AK3_HUMAN No
EAA1_HUMAN No
EBP_HUMAN No
EI24_HUMAN No
ELOV1_HUMAN No
EMC10_HUMAN No
EMC1_HUMAN No
EMC2_HUMAN No
EMC3_HUMAN No
EMC4_HUMAN No
EMC6_HUMAN No
EMC7_HUMAN No
EMC8_HUMAN No
EMD_HUMAN No
ENPL_HUMAN No
EPT1_HUMAN No
ERGI2_HUMAN No
ERGI3_HUMAN No
ERO1A_HUMAN No
ERO1B_HUMAN No
ERP29_HUMAN No
ESYT1_HUMAN No
FA2H_HUMAN No
FACE1_HUMAN No
FADS2_HUMAN No
FKBP8_HUMAN No
G6PT1_HUMAN No
GANAB_HUMAN No
GARS_HUMAN No
GLU2B_HUMAN No
GOSR2_HUMAN No
GOT1B_HUMAN No
GPAA1_HUMAN No
GPAT3_HUMAN No
GPAT4_HUMAN No
GPHRA_HUMAN No
GPI8_HUMAN No
GRM1A_HUMAN No
GRP78_HUMAN No
GSTK1_HUMAN No
HACD2_HUMAN No
HACD3_HUMAN No
HM13_HUMAN No
HMDH_HUMAN No
HMOX2_HUMAN No
HSDL2_HUMAN No
HYOU1_HUMAN No
IDH3B_HUMAN No
IKIP_HUMAN No
ILVBL_HUMAN No
ITB1_HUMAN No
JAGN1_HUMAN No
KTAP2_HUMAN No
LAP2A_HUMAN No
LBR_HUMAN No
LCLT1_HUMAN No
LMAN1_HUMAN No
LMBRL_HUMAN No
LMF2_HUMAN No
LNP_HUMAN No
LRC59_HUMAN No
MAGT1_HUMAN No
MAN1_HUMAN No
MBOA2_HUMAN No
MBOA5_HUMAN No
MBOA7_HUMAN No
MFS10_HUMAN No
MGST1_HUMAN No
MLEC_HUMAN No
MMGT1_HUMAN No
MSPD2_HUMAN No
NB5R3_HUMAN No
NCLN_HUMAN No
NCPR_HUMAN No
NDC1_HUMAN No
NDUA5_HUMAN No
NDUA9_HUMAN No
NDUS1_HUMAN No
NDUS2_HUMAN No
NDUS3_HUMAN No
NDUS8_HUMAN No
NDUV2_HUMAN No
NGBR_HUMAN No
NIPS1_HUMAN No
NRAM2_HUMAN No
NSDHL_HUMAN No
NSMA3_HUMAN No
NU205_HUMAN No
NUCB2_HUMAN No
ORML2_HUMAN No
ORML3_HUMAN No
OSBL8_HUMAN No
OST48_HUMAN No
P4HA1_HUMAN No
P5I11_HUMAN No
PAQR2_HUMAN No
PDIA1_HUMAN No
PDIA3_HUMAN No
PDIA4_HUMAN No
PDIA6_HUMAN No
PGRC1_HUMAN No
PGRC2_HUMAN No
PIGS_HUMAN No
PIGT_HUMAN No
PIGU_HUMAN No
PLOD1_HUMAN No
PLOD3_HUMAN Yes: O60568 (MoonDB)
PM34_HUMAN No
PPIB_HUMAN No
PRAF2_HUMAN No
PRAF3_HUMAN No
PREB_HUMAN No
PTN1_HUMAN No
PTSS1_HUMAN No
PTSS2_HUMAN No
RAB1A_HUMAN No
RAB31_HUMAN No
RAB7A_HUMAN No
RABL3_HUMAN No
RCN1_HUMAN No
RCN2_HUMAN No
REEP2_HUMAN No
REEP4_HUMAN No
REEP5_HUMAN No
RENR_HUMAN No
RER1_HUMAN No
RFT1_HUMAN No
RHBD2_HUMAN No
RPB1_HUMAN No
RPN1_HUMAN No
RPN2_HUMAN No
RTN3_HUMAN No
S12A2_HUMAN No
S35B4_HUMAN No
S38A2_HUMAN No
S38A9_HUMAN No
S39A7_HUMAN No
S39AA_HUMAN No
SAMD8_HUMAN No
SAR1A_HUMAN No
SC11A_HUMAN No
SC22B_HUMAN No
SC6A8_HUMAN No
SCAM2_HUMAN No
SCD5_HUMAN No
SEC63_HUMAN No
SENP3_HUMAN No
SEP15_HUMAN No
SG196_HUMAN No
SGMR1_HUMAN No
SGPL1_HUMAN No
SL9A1_HUMAN No
SOAT1_HUMAN No
SPCS1_HUMAN No
SPCS2_HUMAN No
SPCS3_HUMAN No
SRPRA_HUMAN No
SRPRB_HUMAN No
SRSF2_HUMAN No
SSRA_HUMAN No
SSRG_HUMAN No
STIM1_HUMAN No
STT3B_HUMAN No
SUN1_HUMAN No
SUN2_HUMAN No
SURF4_HUMAN No
T184C_HUMAN No
TAP1_HUMAN No
TAP2_HUMAN No
TAPT1_HUMAN No
TBL2_HUMAN No
TCTE1_HUMAN No
TFR1_HUMAN No
THEM6_HUMAN No
TLCD1_HUMAN No
TLCD2_HUMAN No
TM109_HUMAN No
TM189_HUMAN No
TM199_HUMAN No
TM209_HUMAN No
TM214_HUMAN No
TM245_HUMAN No
TM35B_HUMAN No
TM38B_HUMAN No
TM41A_HUMAN No
TM41B_HUMAN No
TM9S2_HUMAN No
TM9S3_HUMAN No
TMCO1_HUMAN No
TMED2_HUMAN No
TMED9_HUMAN No
TMM33_HUMAN No
TMM43_HUMAN No
TMTC3_HUMAN No
TMX1_HUMAN No
TMX3_HUMAN No
TOIP1_HUMAN No
TOIP2_HUMAN No
TRAM1_HUMAN No
TRI13_HUMAN No
TRPM7_HUMAN No
TXND5_HUMAN No
UB2J1_HUMAN No
UBXN4_HUMAN No
UFL1_HUMAN No
UGGG1_HUMAN No
UN93B_HUMAN No
VANG1_HUMAN No
VAS1_HUMAN No
VATF_HUMAN No
VATL_HUMAN No
VEZA_HUMAN No
VKORL_HUMAN No
VMA21_HUMAN No
VMP1_HUMAN No
VPP1_HUMAN No
VPP2_HUMAN No
VRK2_HUMAN No
WFS1_HUMAN No
WLS_HUMAN No
YIF1A_HUMAN No
YIF1B_HUMAN No
YKT6_HUMAN No
ZNT5_HUMAN No
ZNT6_HUMAN No
ZNT7_HUMAN No
PMID Article Title
12975309 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16357211 Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
17464193 Identification of novel regulators of apoptosis using a high-throughput cell-based screen.
17974005 The full-ORF clone resource of the German cDNA consortium.
22883145 TCTN3 mutations cause Mohr-Majewski syndrome.
27377014 MKS1 mutations cause Joubert syndrome with agenesis of the corpus callosum.
OMIM ID Disease Name
258860 Orofaciodigital syndrome 4
614815 Joubert syndrome 18
Domain Name Domain ID Source
DUF1619 IPR011677 InterPro
DUF1619 PF07773 Pfam
T08708 T08708 PIR