Protein: Q6NUS6

Uniprot: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 48 GO:0009059 macromolecule biosynthetic process 672 6.37e-04 1.88e-40
GO:0006139 nucleobase-containing compound metabolic process 189, 452 GO:0007165 signal transduction 828 1.10e-111 5.07e-25
Module ID (MoonGO) GO ID (BP) GO Name
8 GO:0008219 cell death
8 GO:0019538 protein metabolic process
8 GO:0007165 signal transduction
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
128 GO:0007165 signal transduction
189 GO:0090304 nucleic acid metabolic process
257 GO:0044267 cellular protein metabolic process
257 GO:0007165 signal transduction
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
452 GO:0090304 nucleic acid metabolic process
452 GO:0010468 regulation of gene expression
452 GO:0007165 signal transduction
481 GO:0044267 cellular protein metabolic process
481 GO:0007165 signal transduction
537 GO:0060255 regulation of macromolecule metabolic process
537 GO:0007165 signal transduction
621 GO:0006355 regulation of transcription, DNA-templated
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
769 GO:0007165 signal transduction
828 GO:0007166 cell surface receptor signaling pathway
Module ID (MoonGO) GO ID (CC) GO Name
8 GO:0012505 endomembrane system
8 GO:0016021 integral component of membrane
14 GO:0031410 cytoplasmic vesicle
14 GO:0005829 cytosol
14 GO:0005783 endoplasmic reticulum
39 GO:0043232 intracellular non-membrane-bounded organelle
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
85 GO:0016021 integral component of membrane
128 GO:0012505 endomembrane system
128 GO:0016021 integral component of membrane
128 GO:0005886 plasma membrane
168 GO:0012505 endomembrane system
168 GO:0016021 integral component of membrane
174 GO:0016021 integral component of membrane
179 GO:0012505 endomembrane system
189 GO:0005634 nucleus
257 GO:0031982 vesicle
264 GO:0012505 endomembrane system
350 GO:0012505 endomembrane system
350 GO:0031224 intrinsic component of membrane
366 GO:0005783 endoplasmic reticulum
366 GO:0016021 integral component of membrane
380 GO:0005634 nucleus
388 GO:0016021 integral component of membrane
389 GO:0012505 endomembrane system
389 GO:0016021 integral component of membrane
431 GO:0005829 cytosol
452 GO:0005829 cytosol
452 GO:0070013 intracellular organelle lumen
452 GO:0044428 nuclear part
481 GO:0005634 nucleus
537 GO:0012505 endomembrane system
600 GO:0005634 nucleus
621 GO:0005634 nucleus
666 GO:0016021 integral component of membrane
672 GO:0031981 nuclear lumen
755 GO:0005829 cytosol
799 GO:0012505 endomembrane system
799 GO:0016021 integral component of membrane
828 GO:0016021 integral component of membrane
828 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process IEA
GO:0007224 smoothened signaling pathway IMP
GO:0043065 positive regulation of apoptotic process IDA
GO:0060271 cilium assembly ISS
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0016021 integral component of membrane IEA
GO:0060170 ciliary membrane TAS
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
Interactor Also a MoonDB EMF protein
JPH1_HUMAN No
DRS7B_HUMAN No
T120B_HUMAN No
1A69_HUMAN No
AAAS_HUMAN No
ABCBA_HUMAN No
ABD12_HUMAN No
ACATN_HUMAN No
ACDSB_HUMAN No
ACOD_HUMAN No
ACSL3_HUMAN No
AL1B1_HUMAN No
AL3A2_HUMAN No
ALG3_HUMAN No
ALG6_HUMAN No
ALG9_HUMAN No
AMRP_HUMAN No
ANKL2_HUMAN No
ANO6_HUMAN No
APOL2_HUMAN No
ASIC1_HUMAN No
AT131_HUMAN No
AT1A1_HUMAN No
AT2A2_HUMAN No
AUP1_HUMAN No
B9D2_HUMAN No
BAP31_HUMAN No
BET1_HUMAN No
BRI3B_HUMAN No
C1QBP_HUMAN No
C2D2A_HUMAN No
CAC1A_HUMAN No
CALR_HUMAN No
CALU_HUMAN No
CALX_HUMAN No
CAMLG_HUMAN No
CC115_HUMAN No
CCD47_HUMAN No
CDKAL_HUMAN No
CDS2_HUMAN No
CERS1_HUMAN No
CERS2_HUMAN No
CGT_HUMAN No
CHPT1_HUMAN No
CISD2_HUMAN No
CKAP4_HUMAN No
CLCC1_HUMAN No
CLCN7_HUMAN No
CLGN_HUMAN No
CLP1L_HUMAN No
CNIH4_HUMAN No
COPE_HUMAN No
CYB5B_HUMAN No
D19L1_HUMAN No
D19L3_HUMAN No
DAD1_HUMAN No
DDX47_HUMAN No
DDX54_HUMAN No
DEGS1_HUMAN No
DEP1B_HUMAN No
DERL1_HUMAN No
DERL2_HUMAN No
DGAT1_HUMAN No
DGKE_HUMAN No
DHB12_HUMAN No
DHCR7_HUMAN No
DHRS7_HUMAN No
DJB11_HUMAN No
DJC10_HUMAN No
DJC11_HUMAN No
DJC16_HUMAN No
DNJC1_HUMAN No
DNJC3_HUMAN No
DOPP1_HUMAN No
E2AK3_HUMAN No
EAA1_HUMAN No
EBP_HUMAN No
EI24_HUMAN No
ELOV1_HUMAN No
EMC10_HUMAN No
EMC1_HUMAN No
EMC2_HUMAN No
EMC3_HUMAN No
EMC4_HUMAN No
EMC6_HUMAN No
EMC7_HUMAN No
EMC8_HUMAN No
EMD_HUMAN No
ENPL_HUMAN No
EPT1_HUMAN No
ERGI2_HUMAN No
ERGI3_HUMAN No
ERO1A_HUMAN No
ERO1B_HUMAN No
ERP29_HUMAN No
ESYT1_HUMAN No
FA2H_HUMAN No
FACE1_HUMAN No
FADS2_HUMAN No
FKBP8_HUMAN No
G6PT1_HUMAN No
GANAB_HUMAN No
GARS_HUMAN No
GLU2B_HUMAN No
GOSR2_HUMAN No
GOT1B_HUMAN No
GPAA1_HUMAN No
GPAT3_HUMAN No
GPAT4_HUMAN No
GPHRA_HUMAN No
GPI8_HUMAN No
GRM1A_HUMAN No
GRP78_HUMAN No
GSTK1_HUMAN No
HACD2_HUMAN No
HACD3_HUMAN No
HM13_HUMAN No
HMDH_HUMAN No
HMOX2_HUMAN No
HSDL2_HUMAN No
HYOU1_HUMAN No
IDH3B_HUMAN No
IKIP_HUMAN No
ILVBL_HUMAN No
ITB1_HUMAN No
JAGN1_HUMAN No
KTAP2_HUMAN No
LAP2A_HUMAN No
LBR_HUMAN No
LCLT1_HUMAN No
LMAN1_HUMAN No
LMBRL_HUMAN No
LMF2_HUMAN No
LNP_HUMAN No
LRC59_HUMAN No
MAGT1_HUMAN No
MAN1_HUMAN No
MBOA2_HUMAN No
MBOA5_HUMAN No
MBOA7_HUMAN No
MFS10_HUMAN No
MGST1_HUMAN No
MLEC_HUMAN No
MMGT1_HUMAN No
MSPD2_HUMAN No
NB5R3_HUMAN No
NCLN_HUMAN No
NCPR_HUMAN No
NDC1_HUMAN No
NDUA5_HUMAN No
NDUA9_HUMAN No
NDUS1_HUMAN No
NDUS2_HUMAN No
NDUS3_HUMAN No
NDUS8_HUMAN No
NDUV2_HUMAN No
NGBR_HUMAN No
NIPS1_HUMAN No
NRAM2_HUMAN No
NSDHL_HUMAN No
NSMA3_HUMAN No
NU205_HUMAN No
NUCB2_HUMAN No
ORML2_HUMAN No
ORML3_HUMAN No
OSBL8_HUMAN No
OST48_HUMAN No
P4HA1_HUMAN No
P5I11_HUMAN No
PAQR2_HUMAN No
PDIA1_HUMAN No
PDIA3_HUMAN No
PDIA4_HUMAN No
PDIA6_HUMAN No
PGRC1_HUMAN No
PGRC2_HUMAN No
PIGS_HUMAN No
PIGT_HUMAN No
PIGU_HUMAN No
PLOD1_HUMAN No
PLOD3_HUMAN Yes: O60568 (MoonDB)
PM34_HUMAN No
PPIB_HUMAN No
PRAF2_HUMAN No
PRAF3_HUMAN No
PREB_HUMAN No
PTN1_HUMAN No
PTSS1_HUMAN No
PTSS2_HUMAN No
RAB1A_HUMAN No
RAB31_HUMAN No
RAB7A_HUMAN No
RABL3_HUMAN No
RCN1_HUMAN No
RCN2_HUMAN No
REEP2_HUMAN No
REEP4_HUMAN No
REEP5_HUMAN No
RENR_HUMAN No
RER1_HUMAN No
RFT1_HUMAN No
RHBD2_HUMAN No
RPB1_HUMAN No
RPN1_HUMAN No
RPN2_HUMAN No
RTN3_HUMAN No
S12A2_HUMAN No
S35B4_HUMAN No
S38A2_HUMAN No
S38A9_HUMAN No
S39A7_HUMAN No
S39AA_HUMAN No
SAMD8_HUMAN No
SAR1A_HUMAN No
SC11A_HUMAN No
SC22B_HUMAN No
SC6A8_HUMAN No
SCAM2_HUMAN No
SCD5_HUMAN No
SEC63_HUMAN No
SENP3_HUMAN No
SEP15_HUMAN No
SG196_HUMAN No
SGMR1_HUMAN No
SGPL1_HUMAN No
SL9A1_HUMAN No
SOAT1_HUMAN No
SPCS1_HUMAN No
SPCS2_HUMAN No
SPCS3_HUMAN No
SRPRA_HUMAN No
SRPRB_HUMAN No
SRSF2_HUMAN No
SSRA_HUMAN No
SSRG_HUMAN No
STIM1_HUMAN No
STT3B_HUMAN No
SUN1_HUMAN No
SUN2_HUMAN No
SURF4_HUMAN No
T184C_HUMAN No
TAP1_HUMAN No
TAP2_HUMAN No
TAPT1_HUMAN No
TBL2_HUMAN No
TCTE1_HUMAN No
TFR1_HUMAN No
THEM6_HUMAN No
TLCD1_HUMAN No
TLCD2_HUMAN No
TM109_HUMAN No
TM189_HUMAN No
TM199_HUMAN No
TM209_HUMAN No
TM214_HUMAN No
TM245_HUMAN No
TM35B_HUMAN No
TM38B_HUMAN No
TM41A_HUMAN No
TM41B_HUMAN No
TM9S2_HUMAN No
TM9S3_HUMAN No
TMCO1_HUMAN No
TMED2_HUMAN No
TMED9_HUMAN No
TMM33_HUMAN No
TMM43_HUMAN No
TMTC3_HUMAN No
TMX1_HUMAN No
TMX3_HUMAN No
TOIP1_HUMAN No
TOIP2_HUMAN No
TRAM1_HUMAN No
TRI13_HUMAN No
TRPM7_HUMAN No
TXND5_HUMAN No
UB2J1_HUMAN No
UBXN4_HUMAN No
UFL1_HUMAN No
UGGG1_HUMAN No
UN93B_HUMAN No
VANG1_HUMAN No
VAS1_HUMAN No
VATF_HUMAN No
VATL_HUMAN No
VEZA_HUMAN No
VKORL_HUMAN No
VMA21_HUMAN No
VMP1_HUMAN No
VPP1_HUMAN No
VPP2_HUMAN No
VRK2_HUMAN No
WFS1_HUMAN No
WLS_HUMAN No
YIF1A_HUMAN No
YIF1B_HUMAN No
YKT6_HUMAN No
ZNT5_HUMAN No
ZNT6_HUMAN No
ZNT7_HUMAN No
PMID Article Title
12975309 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16357211 Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
17464193 Identification of novel regulators of apoptosis using a high-throughput cell-based screen.
17974005 The full-ORF clone resource of the German cDNA consortium.
22883145 TCTN3 mutations cause Mohr-Majewski syndrome.
27377014 MKS1 mutations cause Joubert syndrome with agenesis of the corpus callosum.
OMIM ID Disease Name
258860 Orofaciodigital syndrome 4
614815 Joubert syndrome 18
Domain Name Domain ID Source
DUF1619 IPR011677 InterPro
DUF1619 PF07773 Pfam
T08708 T08708 PIR