Protein: P42858

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P42858 (Uniprot) HD_HUMAN HTT Huntingtin human No
Uniprot: May play a role in microtubule-mediated transport or vesicle function.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 222, 345 GO:0007165 signal transduction 486 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
17 GO:0006355 regulation of transcription, DNA-templated
51 GO:0060255 regulation of macromolecule metabolic process
120 GO:0006464 cellular protein modification process
120 GO:0070887 cellular response to chemical stimulus
120 GO:0031324 negative regulation of cellular metabolic process
120 GO:0010605 negative regulation of macromolecule metabolic process
120 GO:0051172 negative regulation of nitrogen compound metabolic process
120 GO:0031325 positive regulation of cellular metabolic process
120 GO:0010604 positive regulation of macromolecule metabolic process
120 GO:0051173 positive regulation of nitrogen compound metabolic process
120 GO:0006355 regulation of transcription, DNA-templated
120 GO:0007165 signal transduction
214 GO:0044267 cellular protein metabolic process
214 GO:0006355 regulation of transcription, DNA-templated
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
244 GO:0006464 cellular protein modification process
244 GO:0060255 regulation of macromolecule metabolic process
244 GO:0007165 signal transduction
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
412 GO:0019538 protein metabolic process
412 GO:0060255 regulation of macromolecule metabolic process
424 GO:0006464 cellular protein modification process
424 GO:0033554 cellular response to stress
424 GO:0045893 positive regulation of transcription, DNA-templated
424 GO:0006357 regulation of transcription from RNA polymerase II promoter
424 GO:0007165 signal transduction
427 GO:0044267 cellular protein metabolic process
427 GO:0010467 gene expression
427 GO:0060255 regulation of macromolecule metabolic process
473 GO:0060255 regulation of macromolecule metabolic process
473 GO:0007165 signal transduction
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
645 GO:0060255 regulation of macromolecule metabolic process
701 GO:0031327 negative regulation of cellular biosynthetic process
701 GO:0010558 negative regulation of macromolecule biosynthetic process
701 GO:0051172 negative regulation of nitrogen compound metabolic process
701 GO:0006357 regulation of transcription from RNA polymerase II promoter
701 GO:0007165 signal transduction
758 GO:0016070 RNA metabolic process
758 GO:0034645 cellular macromolecule biosynthetic process
758 GO:0044271 cellular nitrogen compound biosynthetic process
758 GO:0044267 cellular protein metabolic process
758 GO:0009893 positive regulation of metabolic process
758 GO:0010468 regulation of gene expression
758 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
17 GO:0005829 cytosol
17 GO:0005654 nucleoplasm
43 GO:0005634 nucleus
51 GO:0005634 nucleus
120 GO:0005829 cytosol
120 GO:0043232 intracellular non-membrane-bounded organelle
120 GO:0005654 nucleoplasm
214 GO:0044428 nuclear part
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
232 GO:0005829 cytosol
232 GO:0043232 intracellular non-membrane-bounded organelle
244 GO:0005829 cytosol
244 GO:0043232 intracellular non-membrane-bounded organelle
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
376 GO:0005829 cytosol
376 GO:0005634 nucleus
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
412 GO:0005829 cytosol
412 GO:0005634 nucleus
424 GO:0005829 cytosol
424 GO:0005654 nucleoplasm
427 GO:0070013 intracellular organelle lumen
473 GO:0005634 nucleus
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
502 GO:0005829 cytosol
502 GO:0031981 nuclear lumen
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
555 GO:0005634 nucleus
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
645 GO:0005829 cytosol
645 GO:0005634 nucleus
701 GO:0005654 nucleoplasm
710 GO:0005829 cytosol
710 GO:0070013 intracellular organelle lumen
710 GO:0005634 nucleus
758 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000132 establishment of mitotic spindle orientation IMP
GO:0006869 lipid transport IEA
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP
GO:0006915 apoptotic process IEA
GO:0007030 Golgi organization IMP
GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IDA
GO:0031648 protein destabilization IMP
GO:0042297 vocal learning IMP
GO:0043065 positive regulation of apoptotic process IDA
GO:0043666 regulation of phosphoprotein phosphatase activity IMP
GO:0045724 positive regulation of cilium assembly IMP
GO:0047496 vesicle transport along microtubule IMP
GO:0048513 animal organ development IBA
GO:1903599 positive regulation of autophagy of mitochondrion IMP
GO:1904504 positive regulation of lipophagy IMP
GO:1905337 positive regulation of aggrephagy IMP
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IMP
GO:0005654 nucleoplasm IDA
GO:0005737 cytoplasm IDA
GO:0005770 late endosome IDA
GO:0005776 autophagosome IDA
GO:0005783 endoplasmic reticulum IDA
GO:0005794 Golgi apparatus IDA
GO:0005814 centriole IDA
GO:0005829 cytosol IDA
GO:0016234 inclusion body IMP
GO:0030424 axon IDA
GO:0030425 dendrite IDA
GO:0030659 cytoplasmic vesicle membrane IDA
GO:0043234 protein complex IDA
GO:0048471 perinuclear region of cytoplasm IMP
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005770 late endosome 4.75e-02 1.57e-04
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0030659 cytoplasmic vesicle membrane 4.71e-30 7.28e-80
GO:0005654 nucleoplasm GO:0005783 endoplasmic reticulum 1.84e-53 1.21e-118
GO:0005654 nucleoplasm GO:0005794 Golgi apparatus 1.14e-11 3.23e-62
GO:0005654 nucleoplasm GO:0030424 axon 9.82e-03 1.17e-43
GO:0005654 nucleoplasm GO:0030659 cytoplasmic vesicle membrane 1.28e-24 2.03e-103
Interactor Also a MoonDB EMF protein
GASP2_HUMAN No
ING5_HUMAN No
MAGA3_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
OPTN_HUMAN No
ZDH17_HUMAN No
LDOC1_HUMAN No
IFT20_HUMAN No
API5_HUMAN No
XRCC6_HUMAN Yes: P12956 (MoonDB)
MED21_HUMAN No
TTC23_HUMAN No
ZMAT2_HUMAN No
G3V1X1_HUMAN No
CEP63_HUMAN No
WDR91_HUMAN No
1433B_HUMAN No
ADDG_HUMAN No
ANCHR_HUMAN No
ANM2_HUMAN No
AP2A2_HUMAN No
APBB2_HUMAN No
ARFG3_HUMAN No
BAIP2_HUMAN No
BAZ1A_HUMAN No
BRE1A_HUMAN No
BRE1B_HUMAN No
BZW2_HUMAN No
CBP_HUMAN No
CC126_HUMAN No
CE126_HUMAN No
CH60_HUMAN No
CHD3_HUMAN Yes: Q12873 (MoonDB)
CHM4B_HUMAN No
CIP4_HUMAN No
CLAP1_HUMAN No
COPB_HUMAN No
CTNB1_HUMAN No
CUL2_HUMAN No
CUL5_HUMAN No
DCTN2_HUMAN No
DJC11_HUMAN No
DJC21_HUMAN No
DNJA3_HUMAN No
DNJC4_HUMAN No
DOC11_HUMAN No
DOCK9_HUMAN No
DPPA4_HUMAN No
DPYL1_HUMAN No
DUS10_HUMAN No
DYHC1_HUMAN No
DYN1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
ECH1_HUMAN No
EHMT1_HUMAN No
ELP1_HUMAN No
ERC6L_HUMAN No
ETV4_HUMAN No
EVL_HUMAN No
EZRI_HUMAN No
F71F1_HUMAN No
FEM1B_HUMAN No
FEZ1_HUMAN No
FICD_HUMAN No
FNBP4_HUMAN No
FRIL_HUMAN No
G3P_HUMAN Yes: P04406 (MoonDB)
GGA2_HUMAN No
GIT1_HUMAN No
GLP3L_HUMAN No
GRDN_HUMAN No
H31_HUMAN No
HAP1_HUMAN No
HAX1_HUMAN No
HEY2_HUMAN No
HEYL_HUMAN No
HIP1_HUMAN Yes: O00291 (MoonDB)
HM20A_HUMAN No
HMGA1_HUMAN No
HXC11_HUMAN No
HXC4_HUMAN No
HYPK_HUMAN No
HYPM_HUMAN No
IDLC_HUMAN No
IMA4_HUMAN No
IPYR2_HUMAN No
JKIP1_HUMAN No
KLF11_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
MACOI_HUMAN No
MAGB6_HUMAN No
MAGBI_HUMAN No
MAGC2_HUMAN No
MBD1_HUMAN No
MBD4_HUMAN No
MED15_HUMAN No
MED31_HUMAN No
MEF2D_HUMAN No
MEOX1_HUMAN No
MIPEP_HUMAN No
MKRN2_HUMAN No
MOFA1_HUMAN No
MR1L1_HUMAN No
MRE11_HUMAN No
MTSS1_HUMAN No
MTUS1_HUMAN No
NCOR1_HUMAN No
NDKM_HUMAN No
NFKB1_HUMAN No
NUB1_HUMAN No
NUP58_HUMAN No
ODF2L_HUMAN No
OSTF1_HUMAN No
P4HA1_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
P85B_HUMAN No
PACN1_HUMAN No
PALM_HUMAN No
PDK2_HUMAN No
PEPL_HUMAN No
PGES2_HUMAN No
PIAS1_HUMAN No
PIAS4_HUMAN No
PIBF1_HUMAN No
PKCB1_HUMAN No
PPARG_HUMAN Yes: P37231 (MoonDB)
PR40A_HUMAN Yes: O75400 (MoonDB)
PR40B_HUMAN No
PROF2_HUMAN No
PSB7_HUMAN No
PSMD4_HUMAN No
PTK6_HUMAN No
PX11B_HUMAN No
RABX5_HUMAN No
REN3A_HUMAN No
RHG24_HUMAN No
RHG25_HUMAN No
RL4_HUMAN No
SASH1_HUMAN No
SETD2_HUMAN No
SH3G3_HUMAN No
SNAB_HUMAN No
SP1_HUMAN No
SP3_HUMAN No
SPART_HUMAN No
SPT5H_HUMAN No
SRBP2_HUMAN No
SRBS1_HUMAN No
SRGP1_HUMAN No
SRGP2_HUMAN No
SRGP3_HUMAN No
SRRT_HUMAN No
SYUA_HUMAN No
T4S19_HUMAN No
TACC1_HUMAN No
TAF4_HUMAN No
TANK_HUMAN No
TCRG1_HUMAN No
TF3C3_HUMAN No
TGRM1_HUMAN No
TRAD1_HUMAN No
TSH3_HUMAN No
TXD11_HUMAN No
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
UBAC1_HUMAN No
UBE2K_HUMAN Yes: P61086 (MoonDB)
USP9X_HUMAN No
UT14A_HUMAN No
WAC_HUMAN No
WBP4_HUMAN No
XAGE3_HUMAN No
ZN133_HUMAN No
ZN451_HUMAN No
ZN655_HUMAN No
ZN675_HUMAN No
ZNF91_HUMAN No
PMID Article Title
7647777 Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form.
7759106 Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms.
7903579 Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression.
8197474 Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
8458085 A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
8696339 Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
9700202 Huntingtin interacts with a family of WW domain proteins.
10332029 PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
10958656 Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis.
11013077 Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat.
11461154 Identification of the full-length huntingtin-interacting protein p231HBP/HYPB as a DNA-binding factor.
12783847 Huntingtin contains a highly conserved nuclear export signal.
15654337 Polyglutamine expansion of huntingtin impairs its nuclear export.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16391387 Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
17141218 Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin.
17611284 Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.
18088087 Phosphoproteome of resting human platelets.
18573880 Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19748341 Secondary structure of Huntingtin amino-terminal region.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21685499 Mass spectrometric identification of novel lysine acetylation sites in huntingtin.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
26198635 Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases.
26740508 Identification of novel genetic causes of Rett syndrome-like phenotypes.
27329733 A novel neurodevelopmental disorder associated with compound heterozygous variants in the huntingtin gene.
28757145 Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase.
28882895 Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.
OMIM ID Disease Name
143100 Huntington disease
617435 Lopes-Maciel-Rodan syndrome
Domain Name Domain ID Source
A46068 A46068 PIR
Huntingtin IPR000091 InterPro
Lipovitellin_superhlx_dom IPR011030 InterPro
ARM-like IPR011989 InterPro
ARM-type_fold IPR016024 InterPro
Huntingtin_middle-repeat IPR024613 InterPro
Huntingtin_fam IPR028426 InterPro
DUF3652 PF12372 Pfam
HUNTINGTIN PR00375 PRINTS
PTHR10170 PTHR10170 PANTHER
SSF48371 SSF48371 SUPFAM