Function 1: Functions as aconitase, citrate to isocitrate. Binds sulfur-iron clusters. Condition: high cellular iron concentration.
Function 2: Functions as mRNA binding protein by binding several IRE in the 3' untranslated region of the transferrin receptor mRNA and controls the degradation of transferrin receptor mRNA. Condition: low cellular iron concentration.
Publications (PMID): 1334546, 1444477, 18261896, 15877277