Protein: P19174

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P19174 (Uniprot) PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 human No
Uniprot: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35 5.53e-55 9.57e-64
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 35 4.22e-144 6.90e-18
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35 1.59e-39 2.52e-03
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000186 activation of MAPKK activity TAS
GO:0001701 in utero embryonic development IEA
GO:0007165 signal transduction TAS
GO:0007173 epidermal growth factor receptor signaling pathway IMP
GO:0007411 axon guidance TAS
GO:0009395 phospholipid catabolic process IEA
GO:0010634 positive regulation of epithelial cell migration IMP
GO:0016032 viral process IEA
GO:0016477 cell migration IMP
GO:0019722 calcium-mediated signaling IMP
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA
GO:0043647 inositol phosphate metabolic process TAS
GO:0045766 positive regulation of angiogenesis IDA
GO:0050852 T cell receptor signaling pathway TAS
GO:0050900 leukocyte migration TAS
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IMP
GO:0071364 cellular response to epidermal growth factor stimulus IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001726 ruffle IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005911 cell-cell junction IEA
GO:0008180 COP9 signalosome IDA
GO:0030027 lamellipodium IDA
GO:0042995 cell projection IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
3BP2_HUMAN No
DTBP1_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
SUV92_HUMAN No
HCK_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
AIRE_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
S23A1_HUMAN No
TRAIP_HUMAN No
RAG1_HUMAN No
RACK1_HUMAN No
FAK1_HUMAN No
LAT_HUMAN No
EF1A1_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
ABL1_HUMAN Yes: P00519 (MoonDB)
PAR3_HUMAN No
A0A0U1RR93_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ADNP_HUMAN No
AFF2_HUMAN No
AKAP2_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANT3_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
BICRA_HUMAN No
CAF1A_HUMAN No
CBL_HUMAN No
CKAP5_HUMAN No
CSMD2_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLX4_HUMAN No
DNLI3_HUMAN No
DUS15_HUMAN No
EFS_HUMAN No
EPHB2_HUMAN No
EPOR_HUMAN No
ERBB3_HUMAN Yes: P21860 (MoonDB)
EXTL3_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FCG2B_HUMAN No
FCG2C_HUMAN No
FGFR1_HUMAN No
FGFR2_HUMAN No
FLNB_HUMAN No
FLNC_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GHR_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
IL3RA_HUMAN No
JAK2_HUMAN No
KIT_HUMAN No
LCP2_HUMAN No
LIPA4_HUMAN No
M4K1_HUMAN No
MAP4_HUMAN No
MEPE_HUMAN No
MET_HUMAN No
MINT_HUMAN No
NELFB_HUMAN No
NELL1_HUMAN No
NTRK1_HUMAN No
NTRK2_HUMAN No
PDIA2_HUMAN No
PECA1_HUMAN No
PERE_HUMAN No
PGFRA_HUMAN No
PGFRB_HUMAN No
PHAR2_HUMAN No
PLCG2_HUMAN Yes: P16885 (MoonDB)
PLD1_HUMAN No
RET_HUMAN No
RGS7_HUMAN No
RL13_HUMAN No
RRAS_HUMAN No
RYR1_HUMAN No
SC24B_HUMAN No
SHAN2_HUMAN No
SHAN3_HUMAN No
SNX17_HUMAN No
SNX7_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
TDRD1_HUMAN No
TGON2_HUMAN No
UFO_HUMAN No
VAV_HUMAN No
VGFR1_HUMAN No
ZP2_HUMAN No
PMID Article Title
1370476 Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.
1656221 A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
2167438 Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
7518429 Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
7681365 Solution structure of the SH3 domain of phospholipase C-gamma.
8657103 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
9038210 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
9178760 Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
9489702 LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
10102632 Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.
10488157 Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
10747847 Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.
10873601 Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1.
11259588 Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.
11518702 The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
11564877 Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
12913111 The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.
15102829 Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15215251 Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.
15270728 Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.
15488758 TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
15863030 Cellular signaling by fibroblast growth factor receptors.
16081816 Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.
16844695 Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.
17229814 Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.
17561467 Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.
17620338 Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
18669648 A quantitative atlas of mitotic phosphorylation.
19286672 A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20494825 Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21765395 Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
22561606 Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
A36466 A36466 PIR
C2_dom IPR000008 InterPro
PLipase_C_PInositol-sp_X_dom IPR000909 InterPro
SH2 IPR000980 InterPro
PI-PLC_fam IPR001192 InterPro
SH3_domain IPR001452 InterPro
PLipase_C_Pinositol-sp_Y IPR001711 InterPro
PH_domain IPR001849 InterPro
EF_hand_dom IPR002048 InterPro
EF-hand-dom_pair IPR011992 InterPro
PH-like_dom_sf IPR011993 InterPro
PLC-gamma IPR016279 InterPro
PLC-like_Pdiesterase_TIM-brl IPR017946 InterPro
EF_Hand_1_Ca_BS IPR018247 InterPro
PLC-gamma1 IPR028380 InterPro
PLC-gamma_C-SH2 IPR035023 InterPro
PLC-gamma_N-SH2 IPR035024 InterPro
PLCgamma1_SH3 IPR035724 InterPro
C2_domain_sf IPR035892 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
C2 PF00168 Pfam
PI-PLC-Y PF00387 Pfam
PI-PLC-X PF00388 Pfam
PLC-gamma PIRSF000952 PIRSF
PHPHLIPASEC PR00390 PRINTS
SH2DOMAIN PR00401 PRINTS
EF_HAND_1 PS00018 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PH_DOMAIN PS50003 PROSITE
C2 PS50004 PROSITE
PIPLC_X_DOMAIN PS50007 PROSITE
PIPLC_Y_DOMAIN PS50008 PROSITE
EF_HAND_2 PS50222 PROSITE
PTHR10336 PTHR10336 PANTHER
PTHR10336:SF52 PTHR10336:SF52 PANTHER
PLCXc SM00148 SMART
PLCYc SM00149 SMART
PH SM00233 SMART
C2 SM00239 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF47473 SSF47473 SUPFAM
SSF49562 SSF49562 SUPFAM
SSF50044 SSF50044 SUPFAM
SSF50729 SSF50729 SUPFAM
SSF51695 SSF51695 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_C-SH2_PLC_gamma_like cd09932 CDD
SH2_N-SH2_PLC_gamma_like cd10341 CDD
SH3_PLCgamma1 cd11970 CDD