Protein: P07900

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P07900 (Uniprot) HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha human No
Uniprot: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 24, 323 GO:0033036 macromolecule localization 517 4.56e-06 3.25e-28
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 157, 211 6.37e-04 1.88e-40
GO:0009059 macromolecule biosynthetic process 157, 211 GO:0033036 macromolecule localization 517 2.32e-08 6.09e-30
GO:0007165 signal transduction 308, 512 GO:0006725 cellular aromatic compound metabolic process 81, 484 5.44e-126 5.27e-27
GO:0006725 cellular aromatic compound metabolic process 484 GO:0033036 macromolecule localization 517 1.29e-20 6.46e-74
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
81 GO:0006139 nucleobase-containing compound metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
157 GO:0034645 cellular macromolecule biosynthetic process
157 GO:0044267 cellular protein metabolic process
157 GO:0090304 nucleic acid metabolic process
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
316 GO:0044267 cellular protein metabolic process
316 GO:0060255 regulation of macromolecule metabolic process
323 GO:0016070 RNA metabolic process
323 GO:0034654 nucleobase-containing compound biosynthetic process
323 GO:0009893 positive regulation of metabolic process
323 GO:0006468 protein phosphorylation
323 GO:2000112 regulation of cellular macromolecule biosynthetic process
323 GO:0010468 regulation of gene expression
323 GO:0019219 regulation of nucleobase-containing compound metabolic process
323 GO:0007165 signal transduction
337 GO:0022607 cellular component assembly
337 GO:0035556 intracellular signal transduction
337 GO:0006468 protein phosphorylation
337 GO:0060255 regulation of macromolecule metabolic process
434 GO:0044267 cellular protein metabolic process
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
579 GO:0006464 cellular protein modification process
579 GO:0060255 regulation of macromolecule metabolic process
579 GO:0007165 signal transduction
622 GO:0007165 signal transduction
821 GO:0006259 DNA metabolic process
821 GO:0007166 cell surface receptor signaling pathway
821 GO:0034613 cellular protein localization
821 GO:0071495 cellular response to endogenous stimulus
821 GO:0071310 cellular response to organic substance
821 GO:0031324 negative regulation of cellular metabolic process
821 GO:0010605 negative regulation of macromolecule metabolic process
821 GO:0051172 negative regulation of nitrogen compound metabolic process
821 GO:0031328 positive regulation of cellular biosynthetic process
821 GO:0010557 positive regulation of macromolecule biosynthetic process
821 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
821 GO:0048584 positive regulation of response to stimulus
821 GO:0006468 protein phosphorylation
821 GO:0031399 regulation of protein modification process
821 GO:0006355 regulation of transcription, DNA-templated
821 GO:1901700 response to oxygen-containing compound
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
125 GO:0005829 cytosol
125 GO:0005634 nucleus
155 GO:0005634 nucleus
157 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
247 GO:0005634 nucleus
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
301 GO:0005829 cytosol
301 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
316 GO:0005634 nucleus
323 GO:0005829 cytosol
323 GO:0043232 intracellular non-membrane-bounded organelle
323 GO:0070013 intracellular organelle lumen
323 GO:0044428 nuclear part
337 GO:0005829 cytosol
337 GO:0043232 intracellular non-membrane-bounded organelle
337 GO:0005634 nucleus
434 GO:0005829 cytosol
434 GO:0070062 extracellular exosome
434 GO:0005634 nucleus
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
512 GO:0005829 cytosol
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
622 GO:0005829 cytosol
622 GO:0070013 intracellular organelle lumen
622 GO:0005634 nucleus
821 GO:0005829 cytosol
821 GO:0005654 nucleoplasm
821 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0006839 mitochondrial transport TAS
GO:0006898 receptor-mediated endocytosis TAS
GO:0006986 response to unfolded protein NAS
GO:0007004 telomere maintenance via telomerase IDA
GO:0007165 signal transduction NAS
GO:0009408 response to heat ISS
GO:0009409 response to cold ISS
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
GO:0018108 peptidyl-tyrosine phosphorylation IEA
GO:0031396 regulation of protein ubiquitination IDA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042026 protein refolding TAS
GO:0043254 regulation of protein complex assembly NAS
GO:0043312 neutrophil degranulation TAS
GO:0043335 protein unfolding NAS
GO:0045040 protein import into mitochondrial outer membrane IDA
GO:0045429 positive regulation of nitric oxide biosynthetic process ISS
GO:0046677 response to antibiotic ISS
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0050821 protein stabilization TAS
GO:0050999 regulation of nitric-oxide synthase activity TAS
GO:0051131 chaperone-mediated protein complex assembly IDA
GO:0051973 positive regulation of telomerase activity IDA
GO:0061684 chaperone-mediated autophagy TAS
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO:1900034 regulation of cellular response to heat TAS
GO:1905323 telomerase holoenzyme complex assembly IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0016020 membrane IDA
GO:0032587 ruffle membrane IEA
GO:0034774 secretory granule lumen TAS
GO:0042470 melanosome IEA
GO:0043202 lysosomal lumen TAS
GO:0043209 myelin sheath IEA
GO:0043234 protein complex IDA
GO:0070062 extracellular exosome IDA
GO:0071682 endocytic vesicle lumen TAS
GO:1904813 ficolin-1-rich granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
CSK21_HUMAN Yes: P68400 (MoonDB)
SGTA_HUMAN No
KEAP1_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
MOS_HUMAN No
HSPB1_HUMAN Yes: P04792 (MoonDB)
PPP5_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
TEBP_HUMAN No
HSF1_HUMAN Yes: Q00613 (MoonDB)
CDC37_HUMAN Yes: Q16543 (MoonDB)
NPHP4_HUMAN No
SYQ_HUMAN No
HS71A_HUMAN No
RAF1_HUMAN Yes: P04049 (MoonDB)
ERBB2_HUMAN Yes: P04626 (MoonDB)
NAL12_HUMAN No
SKP2_HUMAN No
STK11_HUMAN No
KLH38_HUMAN No
DNJC7_HUMAN No
TSSK6_HUMAN No
NOD1_HUMAN No
KSR2_HUMAN No
1A02_HUMAN No
ACTB_HUMAN No
AGO3_HUMAN No
AHSA1_HUMAN No
AKT3_HUMAN No
AMHR2_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
AP3D1_HUMAN No
CADH1_HUMAN No
CC117_HUMAN No
CD37L_HUMAN No
CDK13_HUMAN No
CDK15_HUMAN No
CDK9_HUMAN No
CERS2_HUMAN No
CHRD1_HUMAN No
DYRK4_HUMAN No
ERBB4_HUMAN No
ERR2_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FANCC_HUMAN No
FBX24_HUMAN No
FBX25_HUMAN No
FBXW2_HUMAN No
GCR_HUMAN No
GNA12_HUMAN No
HIF1A_HUMAN No
HMN1_HUMAN No
HP1B3_HUMAN No
ICK_HUMAN No
IKKA_HUMAN No
IRF3_HUMAN No
ITBP2_HUMAN No
JUN_HUMAN No
KAPCB_HUMAN No
KLHL1_HUMAN No
KPCZ_HUMAN Yes: Q05513 (MoonDB)
KPSH2_HUMAN No
LRP1_HUMAN No
LSM1_HUMAN No
M3K8_HUMAN No
MUSK_HUMAN No
NOS3_HUMAN No
PAK1_HUMAN Yes: Q13153 (MoonDB)
PIWL1_HUMAN No
PIWL2_HUMAN No
PIWL4_HUMAN No
PKN2_HUMAN No
PPARA_HUMAN No
PPARD_HUMAN No
Q573B4_HUMAN No
Q86WA0_HUMAN No
Q96II5_HUMAN No
RAD51_HUMAN No
RHBT2_HUMAN No
RPAP3_HUMAN No
RS3A_HUMAN No
SGT1_HUMAN No
STA13_HUMAN No
STIP1_HUMAN No
SVIL_HUMAN No
SYDC_HUMAN No
SYEP_HUMAN No
SYMC_HUMAN No
TESK2_HUMAN No
TRI56_HUMAN No
UBP49_HUMAN No
UBP50_HUMAN No
UN45A_HUMAN No
UN45B_HUMAN No
ZBED4_HUMAN No
PMID Article Title
1368637 Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells.
2469626 Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.
2492519 Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.
2507541 The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.
2527334 Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.
2591742 Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.
2780322 Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes.
7588731 Mechanism of dimer formation of the 90-kDa heat-shock protein.
8289821 The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.
9108479 Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
9195923 Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.
9660753 Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.
9817749 In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
10409742 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10508479 Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
11274138 Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.
11276205 A CD14-independent LPS receptor cluster.
11583998 Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.
12508121 The DNA sequence and analysis of human chromosome 14.
12604615 Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.
12853476 Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15235609 SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
15383005 Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15577939 Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
15708368 Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.
15937123 S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.
16139798 Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
16269234 The HSP90 family of genes in the human genome: insights into their divergence and evolution.
16307917 Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
16531226 Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
16807684 Phosphoproteomic analysis of the human pituitary.
17028174 Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18088087 Phosphoproteome of resting human platelets.
18256191 The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.
18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
18400751 Conserved conformational changes in the ATPase cycle of human Hsp90.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19696785 Hsp90 is regulated by a switch point in the C-terminal domain.
19875381 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20353823 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23569206 Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24613385 Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.
24681825 The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
25738358 C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.
25944712 N-terminome analysis of the human mitochondrial proteome.
25973397 Hsp90, the concertmaster: tuning transcription.
26517842 Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
26754925 IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
26991466 Review: The HSP90 molecular chaperone-an enigmatic ATPase.
27295069 Hsp90: Friends, clients and natural foes.
27353360 The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
No results found.
Domain Name Domain ID Source
HHHU86 A32319 PIR
Hsp90_fam IPR001404 InterPro
HATPase_C IPR003594 InterPro
Heat_shock_protein_90_CS IPR019805 InterPro
Ribosomal_S5_D2-typ_fold IPR020568 InterPro
Hsp90_N IPR020575 InterPro
HATPase_C_sf IPR036890 InterPro
HSP90_C IPR037196 InterPro
HSP90 MF_00505 HAMAP
HSP90 PF00183 Pfam
HATPase_c PF02518 Pfam
Hsp90 PIRSF002583 PIRSF
HEATSHOCK90 PR00775 PRINTS
HSP90 PS00298 PROSITE
PTHR11528 PTHR11528 PANTHER
HATPase_c SM00387 SMART
SSF110942 SSF110942 SUPFAM
SSF54211 SSF54211 SUPFAM
SSF55874 SSF55874 SUPFAM
HATPase_c cd00075 CDD