Protein: Q9Y4L5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y4L5 (Uniprot) RN115_HUMAN RNF115 E3 ubiquitin-protein ligase RNF115 human No
Uniprot: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192, 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
175 GO:0005829 cytosol
175 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination TAS
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
GO:0051865 protein autoubiquitination IDA
GO:0070534 protein K63-linked ubiquitination ISS
GO:0070936 protein K48-linked ubiquitination ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16288031 A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16925951 Novel RING E3 ubiquitin ligases in breast cancer.
18819927 Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
23418353 The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
zf-RING_2 PF13639 Pfam
ZF_RING_2 PS50089 PROSITE
RING SM00184 SMART