Protein: Q9QWV4

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9QWV4 (Uniprot) MLF1_MOUSE Mlf1 Myeloid leukemia factor 1 mouse No
Uniprot: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1675 GO:0007165 signal transduction 1492 2.28e-48 1.95e-17
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1492 GO:0035556 intracellular signal transduction
1492 GO:0010646 regulation of cell communication
1492 GO:0060255 regulation of macromolecule metabolic process
1492 GO:0023051 regulation of signaling
1675 GO:0034645 cellular macromolecule biosynthetic process
1675 GO:0044271 cellular nitrogen compound biosynthetic process
1675 GO:0010467 gene expression
1756 GO:0071310 cellular response to organic substance
1756 GO:0031324 negative regulation of cellular metabolic process
1756 GO:0010629 negative regulation of gene expression
1756 GO:0051172 negative regulation of nitrogen compound metabolic process
1756 GO:2000112 regulation of cellular macromolecule biosynthetic process
1756 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1492 GO:0005634 nucleus
1492 GO:0005886 plasma membrane
1675 GO:0005829 cytosol
1675 GO:0005634 nucleus
1756 GO:0005829 cytosol
1756 GO:0005730 nucleolus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002318 myeloid progenitor cell differentiation IDA
GO:0006351 transcription, DNA-templated IDA
GO:0007050 cell cycle arrest ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0031514 motile cilium IDA
GO:0097730 non-motile cilium IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
1433Z_MOUSE No
NUCL_MOUSE No
CYBP_MOUSE No
DYL2_MOUSE No
EIF3G_MOUSE No
NRBP_MOUSE No
PMID Article Title
10393836 cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia.
10523300 HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.
12176995 MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
15122318 Myeloid leukemia factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation.
17008314 Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
No results found.
Domain Name Domain ID Source
Myeloid_leukemia_factor IPR019376 InterPro
Mlf1IP PF10248 Pfam
PTHR13105 PTHR13105 PANTHER