Protein: Q93062

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q93062 (Uniprot) RBPMS_HUMAN RBPMS RNA-binding protein with multiple splicing human No
Uniprot: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 26 GO:0006396 RNA processing 426 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
26 GO:0006464 cellular protein modification process
26 GO:0090304 nucleic acid metabolic process
26 GO:0010468 regulation of gene expression
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
67 GO:0060255 regulation of macromolecule metabolic process
153 GO:0090304 nucleic acid metabolic process
153 GO:0060255 regulation of macromolecule metabolic process
351 GO:0022402 cell cycle process
351 GO:0034645 cellular macromolecule biosynthetic process
351 GO:0044267 cellular protein metabolic process
351 GO:0090304 nucleic acid metabolic process
403 GO:0060255 regulation of macromolecule metabolic process
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
455 GO:0010468 regulation of gene expression
456 GO:0010467 gene expression
456 GO:0090304 nucleic acid metabolic process
462 GO:0090304 nucleic acid metabolic process
490 GO:0031325 positive regulation of cellular metabolic process
490 GO:0010604 positive regulation of macromolecule metabolic process
490 GO:0051173 positive regulation of nitrogen compound metabolic process
490 GO:0009966 regulation of signal transduction
490 GO:0006357 regulation of transcription from RNA polymerase II promoter
507 GO:0010467 gene expression
507 GO:0006139 nucleobase-containing compound metabolic process
649 GO:0016070 RNA metabolic process
649 GO:0010468 regulation of gene expression
673 GO:0090304 nucleic acid metabolic process
727 GO:0060255 regulation of macromolecule metabolic process
760 GO:0010468 regulation of gene expression
783 GO:0031424 keratinization
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
26 GO:0005654 nucleoplasm
60 GO:0005634 nucleus
64 GO:0005634 nucleus
67 GO:0005634 nucleus
153 GO:0005634 nucleus
271 GO:0005634 nucleus
351 GO:0043232 intracellular non-membrane-bounded organelle
351 GO:0005654 nucleoplasm
402 GO:0005829 cytosol
403 GO:0005634 nucleus
422 GO:0005634 nucleus
426 GO:0005654 nucleoplasm
444 GO:0005634 nucleus
455 GO:0005634 nucleus
462 GO:0005634 nucleus
490 GO:0005654 nucleoplasm
507 GO:0044428 nuclear part
641 GO:0005634 nucleus
649 GO:0070013 intracellular organelle lumen
649 GO:0005634 nucleus
673 GO:0005634 nucleus
726 GO:0005634 nucleus
760 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome IBA
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated IEA
GO:0006396 RNA processing TAS
GO:0006979 response to oxidative stress IMP
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
GO:0060391 positive regulation of SMAD protein import into nucleus IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IEA
GO:0005654 nucleoplasm IDA
GO:0005685 U1 snRNP IBA
GO:0005829 cytosol IDA
GO:0010494 cytoplasmic stress granule IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
A0A024R0L9_HUMAN No
6PGL_HUMAN No
A0A024R5S0_HUMAN No
A0A024R857_HUMAN No
A0A0C4DGF1_HUMAN No
A1L4F5_HUMAN No
A8KA13_HUMAN No
AAKB2_HUMAN No
AAPK1_HUMAN No
AAPK2_HUMAN No
ADA15_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AF10_HUMAN No
AMMR1_HUMAN No
APC11_HUMAN No
APEL_HUMAN No
ARG39_HUMAN No
ARI5A_HUMAN No
ARIP4_HUMAN No
ATN1_HUMAN No
ATX1L_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
B2R550_HUMAN No
B3KPT9_HUMAN No
B4DNA4_HUMAN No
BANP_HUMAN No
BBS2_HUMAN No
BCL6B_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
BOLL_HUMAN No
BORG5_HUMAN No
C1AS1_HUMAN No
CA094_HUMAN No
CASK_HUMAN No
CASL_HUMAN No
CC120_HUMAN No
CCER1_HUMAN No
CCNG1_HUMAN No
CCNK_HUMAN No
CDC23_HUMAN No
CH071_HUMAN No
CHCH7_HUMAN No
CJ055_HUMAN No
CK087_HUMAN No
CNNM3_HUMAN No
CO8A1_HUMAN No
CQ055_HUMAN No
CQ113_HUMAN No
CRBA1_HUMAN No
CRBN_HUMAN No
CREB5_HUMAN No
CRX_HUMAN No
CS054_HUMAN No
CT085_HUMAN No
CV039_HUMAN No
CY24A_HUMAN No
D3DTF8_HUMAN No
DAZP2_HUMAN Yes: Q15038 (MoonDB)
DCAF8_HUMAN No
DCD2B_HUMAN No
DCTN5_HUMAN No
DMRT3_HUMAN No
DOK3_HUMAN No
DOK6_HUMAN No
DPYL4_HUMAN No
DTX2_HUMAN No
DVL2_HUMAN No
EAF2_HUMAN No
ENKD1_HUMAN No
EWS_HUMAN No
EYA2_HUMAN No
F124B_HUMAN No
F166B_HUMAN No
F168A_HUMAN No
FASTK_HUMAN No
FBF1_HUMAN No
FBLN4_HUMAN No
FND11_HUMAN No
FOXC2_HUMAN No
FOXP3_HUMAN No
FOXS1_HUMAN No
FRG1_HUMAN No
FXR2_HUMAN No
GATA1_HUMAN No
GATA2_HUMAN No
GCM2_HUMAN No
GLCTK_HUMAN No
GLD2_HUMAN No
GLIS2_HUMAN No
GPS2_HUMAN No
GPT2L_HUMAN No
GRAP2_HUMAN No
GRAP_HUMAN No
GSE1_HUMAN No
HCK_HUMAN No
HEY2_HUMAN No
HEYL_HUMAN No
HNRLL_HUMAN No
HSFY1_HUMAN No
HXA1_HUMAN No
HXA9_HUMAN No
HXB9_HUMAN No
HXC8_HUMAN No
IFG15_HUMAN No
IG2R_HUMAN No
IGF2_HUMAN No
ILF3_HUMAN No
IMA1_HUMAN No
INCA1_HUMAN No
IP6K2_HUMAN No
KCC2A_HUMAN No
KCC2B_HUMAN No
KCTD9_HUMAN No
KI2L4_HUMAN No
KIF1A_HUMAN No
KLD7B_HUMAN No
KR111_HUMAN No
KR121_HUMAN No
KR122_HUMAN No
KR124_HUMAN No
KR151_HUMAN No
KR193_HUMAN No
KR195_HUMAN No
KR197_HUMAN No
KR231_HUMAN No
KR261_HUMAN No
KRA31_HUMAN No
KRA81_HUMAN No
LASP1_HUMAN No
LEG9C_HUMAN No
LMO4_HUMAN No
LONF1_HUMAN No
LRC41_HUMAN No
LZTS2_HUMAN No
MAGD1_HUMAN No
MCM5_HUMAN No
MCM7_HUMAN No
MEIS2_HUMAN No
MGT5B_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
MORN3_HUMAN No
MTMRD_HUMAN No
MVP_HUMAN No
MYH7B_HUMAN No
MYOZ2_HUMAN No
NAB2_HUMAN No
NANP8_HUMAN No
NEUR4_HUMAN No
NKX25_HUMAN No
NR1D2_HUMAN No
NTAQ1_HUMAN Yes: Q96HA8 (MoonDB)
NYNRI_HUMAN No
OTX1_HUMAN No
P121A_HUMAN No
P66B_HUMAN No
PATZ1_HUMAN No
PCH2_HUMAN No
PDLI4_HUMAN No
PER1_HUMAN No
PHF1_HUMAN No
PICAL_HUMAN Yes: Q13492 (MoonDB)
PIHD1_HUMAN No
PIN1_HUMAN No
PITX1_HUMAN No
PITX2_HUMAN No
PLAC8_HUMAN No
PLS4_HUMAN No
PNCB_HUMAN No
PO6F2_HUMAN No
POGZ_HUMAN No
PP16B_HUMAN No
PR20A_HUMAN No
PR20C_HUMAN No
PR20D_HUMAN No
PRR35_HUMAN No
PSMF1_HUMAN No
Q0P5Q0_HUMAN No
Q6ICL0_HUMAN No
Q6NSM0_HUMAN No
Q8N0U1_HUMAN No
Q8N4W5_HUMAN No
Q96D16_HUMAN No
Q96HR4_HUMAN No
Q9NWU8_HUMAN No
Q9NXX0_HUMAN No
QKI_HUMAN No
R3HD2_HUMAN No
RABL6_HUMAN No
RAM_HUMAN No
RASK_HUMAN No
RBM24_HUMAN No
RBM46_HUMAN No
RBPS2_HUMAN No
RDH12_HUMAN No
RFOX1_HUMAN No
RFOX2_HUMAN No
RHBT3_HUMAN No
RHG09_HUMAN No
RHXF2_HUMAN No
RIPP1_HUMAN No
ROR2_HUMAN No
RPC7L_HUMAN No
RPP25_HUMAN No
RSMB_HUMAN No
RTP5_HUMAN No
RU1C_HUMAN No
RUSC1_HUMAN No
S2548_HUMAN No
SEM4G_HUMAN No
SERF2_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
SH3R2_HUMAN No
SIRB1_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
SMAP1_HUMAN No
SMRP1_HUMAN No
SMUG1_HUMAN No
SOSSC_HUMAN No
SPAT8_HUMAN No
SPG7_HUMAN No
SPT46_HUMAN No
STRBP_HUMAN No
T10IP_HUMAN No
TBX6_HUMAN No
TCEA2_HUMAN No
TEKT5_HUMAN No
TEX37_HUMAN No
TF7L2_HUMAN No
TFG_HUMAN Yes: Q92734 (MoonDB)
TIE1_HUMAN No
TINAL_HUMAN No
TMM42_HUMAN No
TNS2_HUMAN Yes: Q63HR2 (MoonDB)
TOLIP_HUMAN No
TRAF4_HUMAN No
TS101_HUMAN Yes: Q99816 (MoonDB)
TSC1_HUMAN No
TSYL6_HUMAN No
TTL10_HUMAN No
TUSC2_HUMAN No
TYB4_HUMAN Yes: P62328 (MoonDB)
VA0D1_HUMAN No
VA0E2_HUMAN No
VENTX_HUMAN No
VEZF1_HUMAN No
VGLL3_HUMAN No
VHLL_HUMAN No
VHL_HUMAN No
VP37C_HUMAN Yes: A5D8V6 (MoonDB)
WDR54_HUMAN No
WDR90_HUMAN No
WIT1_HUMAN No
YPEL3_HUMAN No
Z385C_HUMAN No
ZBT32_HUMAN No
ZC3HA_HUMAN No
ZIC1_HUMAN No
ZN488_HUMAN No
ZN581_HUMAN No
PMID Article Title
8855282 A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.
14759258 An unappreciated role for RNA surveillance.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17099224 Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.
18669648 A quantitative atlas of mitotic phosphorylation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
26347403 Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS.
No results found.
Domain Name Domain ID Source
RRM_dom IPR000504 InterPro
RBD_domain_sf IPR035979 InterPro
JC6127 JC6127 PIR
RRM_1 PF00076 Pfam
RRM PS50102 PROSITE
RRM SM00360 SMART
SSF54928 SSF54928 SUPFAM