Protein: Q16543

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q16543 (Uniprot) CDC37_HUMAN CDC37 Hsp90 co-chaperone Cdc37 human No
Uniprot: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 32, 155, 221, 290, 301 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0006464 cellular protein modification process 195 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0019538 protein metabolic process 434 GO:0016070 RNA metabolic process 689 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
31 GO:0034645 cellular macromolecule biosynthetic process
31 GO:0044271 cellular nitrogen compound biosynthetic process
31 GO:0090304 nucleic acid metabolic process
31 GO:0010468 regulation of gene expression
32 GO:0006464 cellular protein modification process
32 GO:0006955 immune response
32 GO:0002682 regulation of immune system process
32 GO:0007165 signal transduction
54 GO:0010467 gene expression
54 GO:0006139 nucleobase-containing compound metabolic process
54 GO:0060255 regulation of macromolecule metabolic process
81 GO:0006139 nucleobase-containing compound metabolic process
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
195 GO:0006468 protein phosphorylation
195 GO:0010468 regulation of gene expression
195 GO:0051246 regulation of protein metabolic process
195 GO:0007165 signal transduction
221 GO:0006464 cellular protein modification process
221 GO:0071310 cellular response to organic substance
221 GO:0031325 positive regulation of cellular metabolic process
221 GO:0010604 positive regulation of macromolecule metabolic process
221 GO:0051173 positive regulation of nitrogen compound metabolic process
221 GO:0006357 regulation of transcription from RNA polymerase II promoter
221 GO:0007165 signal transduction
290 GO:0006464 cellular protein modification process
290 GO:0031325 positive regulation of cellular metabolic process
290 GO:0009889 regulation of biosynthetic process
290 GO:0060255 regulation of macromolecule metabolic process
290 GO:0007165 signal transduction
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
323 GO:0016070 RNA metabolic process
323 GO:0034654 nucleobase-containing compound biosynthetic process
323 GO:0009893 positive regulation of metabolic process
323 GO:0006468 protein phosphorylation
323 GO:2000112 regulation of cellular macromolecule biosynthetic process
323 GO:0010468 regulation of gene expression
323 GO:0019219 regulation of nucleobase-containing compound metabolic process
323 GO:0007165 signal transduction
434 GO:0044267 cellular protein metabolic process
454 GO:0031326 regulation of cellular biosynthetic process
454 GO:0060255 regulation of macromolecule metabolic process
612 GO:0090304 nucleic acid metabolic process
612 GO:0031325 positive regulation of cellular metabolic process
612 GO:0010604 positive regulation of macromolecule metabolic process
612 GO:0051173 positive regulation of nitrogen compound metabolic process
612 GO:0006468 protein phosphorylation
612 GO:0032268 regulation of cellular protein metabolic process
612 GO:0010468 regulation of gene expression
612 GO:0010556 regulation of macromolecule biosynthetic process
612 GO:0019219 regulation of nucleobase-containing compound metabolic process
612 GO:0042325 regulation of phosphorylation
612 GO:0009966 regulation of signal transduction
622 GO:0007165 signal transduction
683 GO:0006139 nucleobase-containing compound metabolic process
683 GO:0060255 regulation of macromolecule metabolic process
685 GO:0060255 regulation of macromolecule metabolic process
685 GO:0007165 signal transduction
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
695 GO:0006464 cellular protein modification process
695 GO:0035556 intracellular signal transduction
695 GO:0016310 phosphorylation
695 GO:0060255 regulation of macromolecule metabolic process
827 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
31 GO:0005634 nucleus
32 GO:0005886 plasma membrane
32 GO:0031982 vesicle
50 GO:0005829 cytosol
50 GO:0005634 nucleus
54 GO:0070013 intracellular organelle lumen
54 GO:0005634 nucleus
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
82 GO:0005634 nucleus
84 GO:0005634 nucleus
155 GO:0005634 nucleus
162 GO:0005634 nucleus
195 GO:0005829 cytosol
195 GO:0005634 nucleus
216 GO:0005829 cytosol
221 GO:0005829 cytosol
221 GO:0043232 intracellular non-membrane-bounded organelle
221 GO:0005654 nucleoplasm
290 GO:0005829 cytosol
290 GO:0031982 vesicle
293 GO:0005634 nucleus
301 GO:0005829 cytosol
301 GO:0005634 nucleus
307 GO:0005634 nucleus
317 GO:0005829 cytosol
323 GO:0005829 cytosol
323 GO:0043232 intracellular non-membrane-bounded organelle
323 GO:0070013 intracellular organelle lumen
323 GO:0044428 nuclear part
434 GO:0005829 cytosol
434 GO:0070062 extracellular exosome
434 GO:0005634 nucleus
454 GO:0005634 nucleus
532 GO:0005829 cytosol
532 GO:0043232 intracellular non-membrane-bounded organelle
532 GO:0005634 nucleus
612 GO:0005634 nucleus
622 GO:0005829 cytosol
622 GO:0070013 intracellular organelle lumen
622 GO:0005634 nucleus
683 GO:0005829 cytosol
683 GO:0070013 intracellular organelle lumen
683 GO:0005634 nucleus
685 GO:0005829 cytosol
689 GO:0005654 nucleoplasm
695 GO:0005829 cytosol
695 GO:0005634 nucleus
827 GO:0012505 endomembrane system
827 GO:0031982 vesicle
858 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
GO:0006457 protein folding IBA
GO:0006605 protein targeting TAS
GO:0010608 posttranscriptional regulation of gene expression IEA
GO:0018108 peptidyl-tyrosine phosphorylation IEA
GO:0038128 ERBB2 signaling pathway TAS
GO:0050821 protein stabilization IBA
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway IMP
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0070062 extracellular exosome IDA
GO:1990565 HSP90-CDC37 chaperone complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PO6F2_HUMAN No
CEP70_HUMAN No
PR20D_HUMAN No
MDFI_HUMAN No
THAP1_HUMAN No
HSF2B_HUMAN No
CTG1B_HUMAN No
BHLH9_HUMAN No
BEND7_HUMAN No
FATE1_HUMAN No
PROP1_HUMAN No
K2C75_HUMAN No
ZBED1_HUMAN No
ITF2_HUMAN No
KAP1_HUMAN No
TRAF2_HUMAN No
NECA2_HUMAN No
ZBT8A_HUMAN No
ZN837_HUMAN No
KIFC3_HUMAN No
TRI54_HUMAN No
KTBL1_HUMAN No
CARD9_HUMAN No
IKZF3_HUMAN No
CC138_HUMAN No
CGBP1_HUMAN No
ZGPAT_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
PERI_HUMAN No
GG6L9_HUMAN No
USBP1_HUMAN No
SRRM4_HUMAN No
KCC2A_HUMAN No
GMCL1_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
STX1A_HUMAN No
SYCE2_HUMAN No
AMOL2_HUMAN No
TNIP1_HUMAN No
MOS_HUMAN No
GFAP_HUMAN No
CCHCR_HUMAN No
HOME3_HUMAN No
ZN587_HUMAN No
THAP7_HUMAN No
SPERT_HUMAN No
ECSIT_HUMAN No
PDE9A_HUMAN No
CE104_HUMAN No
KCC2B_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
CEP55_HUMAN No
LMNB2_HUMAN No
ZN205_HUMAN No
2AAA_HUMAN No
5NT1A_HUMAN No
A2MG_HUMAN Yes: P01023 (MoonDB)
A4_HUMAN No
AAPK1_HUMAN No
ACTB_HUMAN No
ACTG_HUMAN No
AKT1_HUMAN No
AKT3_HUMAN No
ALS2_HUMAN No
AMHR2_HUMAN No
ANM1_HUMAN No
ANM5_HUMAN No
ANPRB_HUMAN No
APOE_HUMAN Yes: P02649 (MoonDB)
ARBK1_HUMAN No
AURKB_HUMAN No
BACD1_HUMAN No
BACD2_HUMAN No
BTBD3_HUMAN No
BTBDA_HUMAN No
C2D1A_HUMAN No
CALR_HUMAN No
CAR10_HUMAN No
CAVN1_HUMAN No
CCD91_HUMAN No
CDK10_HUMAN No
CDK13_HUMAN No
CDK15_HUMAN No
CDK4_HUMAN No
CDK5_HUMAN No
CDK6_HUMAN Yes: Q00534 (MoonDB)
CDK9_HUMAN No
CL076_HUMAN No
CMGA_HUMAN No
CP2C9_HUMAN No
CRYM_HUMAN No
CS044_HUMAN No
CT194_HUMAN No
CT451_HUMAN No
CUL3_HUMAN No
CUL4A_HUMAN No
CUL4B_HUMAN No
CUTC_HUMAN No
DAPK3_HUMAN No
DCTN1_HUMAN No
DDR2_HUMAN No
DEAF1_HUMAN No
DISC1_HUMAN Yes: Q9NRI5 (MoonDB)
DNJB1_HUMAN No
DPCD_HUMAN No
DPF1_HUMAN No
DUS3L_HUMAN No
E2AK4_HUMAN No
ELAV3_HUMAN No
ELK3_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
EXOS1_HUMAN No
F118A_HUMAN No
FAM9B_HUMAN Yes: Q8IZU0 (MoonDB)
FBX38_HUMAN No
FBXW2_HUMAN No
FBXW4_HUMAN No
FER_HUMAN No
FGFR3_HUMAN No
FKBP4_HUMAN No
FOXM1_HUMAN No
FXL12_HUMAN No
FYN_HUMAN Yes: P06241 (MoonDB)
GAS7_HUMAN No
GAS8_HUMAN No
GCDH_HUMAN No
GCH1_HUMAN No
GO45_HUMAN No
GRAP1_HUMAN No
GRM2B_HUMAN No
GTD2A_HUMAN No
H2AW_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
ICK_HUMAN No
IFIT3_HUMAN No
IFIT5_HUMAN No
IKKA_HUMAN No
IKKE_HUMAN No
K22O_HUMAN No
KAPCB_HUMAN No
KCC2G_HUMAN No
KCTD9_HUMAN No
KERA_HUMAN No
KLD10_HUMAN No
KLH31_HUMAN No
KLHL2_HUMAN No
KPSH2_HUMAN No
KSR2_HUMAN No
LBN_HUMAN No
LC7L2_HUMAN No
LIMK2_HUMAN No
LMX1B_HUMAN No
LONM_HUMAN Yes: P36776 (MoonDB)
LOXL4_HUMAN No
LZTS1_HUMAN No
M3K14_HUMAN No
M3K15_HUMAN No
M3K8_HUMAN No
MAK_HUMAN No
MATK_HUMAN No
MD1L1_HUMAN No
MEF2B_HUMAN No
MIC60_HUMAN No
MIPO1_HUMAN No
MK07_HUMAN No
MOK_HUMAN No
MTOR_HUMAN No
MUSK_HUMAN No
MYLK4_HUMAN No
MZT2B_HUMAN No
NAL12_HUMAN No
NCOA5_HUMAN No
NECA1_HUMAN No
NEK8_HUMAN No
NFRKB_HUMAN No
NOC4L_HUMAN No
NOD1_HUMAN No
NOS3_HUMAN No
NR1I3_HUMAN No
OFD1_HUMAN No
OGA_HUMAN No
PADI4_HUMAN No
PDK1L_HUMAN Yes: Q8N165 (MoonDB)
PDPK1_HUMAN Yes: O15530 (MoonDB)
PIBF1_HUMAN No
PINK1_HUMAN No
PITX2_HUMAN No
PNMA2_HUMAN No
POC1B_HUMAN No
PPHLN_HUMAN No
PRAM_HUMAN No
PRDM1_HUMAN No
PRDX2_HUMAN No
PRS10_HUMAN No
PSME1_HUMAN No
PSN1_HUMAN No
PUR6_HUMAN No
Q15850_HUMAN No
Q573B4_HUMAN No
Q59FJ7_HUMAN No
Q59GL9_HUMAN No
Q6GZ88_HUMAN No
Q86XJ5_HUMAN No
Q96II5_HUMAN No
RABX5_HUMAN No
RAF1_HUMAN Yes: P04049 (MoonDB)
RD23A_HUMAN No
REEP6_HUMAN No
RGS11_HUMAN No
RIPK1_HUMAN No
RM28_HUMAN No
RMP_HUMAN No
RNF32_HUMAN Yes: Q9H0A6 (MoonDB)
ROP1A_HUMAN No
RS15A_HUMAN No
SAFB1_HUMAN No
SEPT3_HUMAN No
SLIK6_HUMAN No
SNX5_HUMAN No
SPTN4_HUMAN No
SQSTM_HUMAN Yes: Q13501 (MoonDB)
SSNA1_HUMAN No
ST32A_HUMAN No
ST38L_HUMAN No
STALP_HUMAN No
STIL_HUMAN No
STK11_HUMAN No
STPAP_HUMAN No
T2FA_HUMAN No
TBB1_HUMAN No
TESK2_HUMAN No
TIE1_HUMAN No
TNK1_HUMAN No
TRAF3_HUMAN Yes: Q13114 (MoonDB)
TRAF5_HUMAN No
TRI18_HUMAN No
TSSK6_HUMAN No
UBP49_HUMAN No
ULK3_HUMAN No
VSX2_HUMAN No
WDR13_HUMAN No
WDR61_HUMAN No
WDR70_HUMAN No
YES_HUMAN No
ZBT20_HUMAN No
ZBT26_HUMAN No
ZBT40_HUMAN No
ZN235_HUMAN No
ZN266_HUMAN No
ZN334_HUMAN No
ZN569_HUMAN No
ZN610_HUMAN No
ZN667_HUMAN No
ZN843_HUMAN No
PMID Article Title
8666233 Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
8703009 Physical interaction of mammalian CDC37 with CDK4.
9150368 Interaction between Cdc37 and Cdk4 in human cells.
9482106 Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
10409742 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10858314 p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
11036079 Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase.
11085988 Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
17709345 Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23569206 Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
27353360 The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
No results found.
Domain Name Domain ID Source
G02313 G02313 PIR
Cdc37 IPR004918 InterPro
Cdc37_N_dom IPR013855 InterPro
Cdc37_C IPR013873 InterPro
Cdc37_Hsp90-bd IPR013874 InterPro
CDC37_N PF03234 Pfam
CDC37_C PF08564 Pfam
CDC37_M PF08565 Pfam
PTHR12800 PTHR12800 PANTHER
CDC37_C SM01069 SMART
CDC37_M SM01070 SMART
CDC37_N SM01071 SMART