Protein: P84022

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P84022 (Uniprot) SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 human No
Uniprot: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 180 4.22e-144 6.90e-18
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 342 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
51 GO:0060255 regulation of macromolecule metabolic process
54 GO:0010467 gene expression
54 GO:0006139 nucleobase-containing compound metabolic process
54 GO:0060255 regulation of macromolecule metabolic process
102 GO:0044267 cellular protein metabolic process
102 GO:0031325 positive regulation of cellular metabolic process
102 GO:0010604 positive regulation of macromolecule metabolic process
102 GO:0051173 positive regulation of nitrogen compound metabolic process
102 GO:0006355 regulation of transcription, DNA-templated
102 GO:0007165 signal transduction
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
107 GO:0016070 RNA metabolic process
107 GO:0044267 cellular protein metabolic process
107 GO:0034654 nucleobase-containing compound biosynthetic process
107 GO:2000112 regulation of cellular macromolecule biosynthetic process
107 GO:0010468 regulation of gene expression
107 GO:0019219 regulation of nucleobase-containing compound metabolic process
107 GO:0007165 signal transduction
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
220 GO:0060255 regulation of macromolecule metabolic process
248 GO:0044267 cellular protein metabolic process
248 GO:0045893 positive regulation of transcription, DNA-templated
248 GO:0051246 regulation of protein metabolic process
248 GO:0007165 signal transduction
266 GO:0034645 cellular macromolecule biosynthetic process
266 GO:0044271 cellular nitrogen compound biosynthetic process
266 GO:0006464 cellular protein modification process
266 GO:0070887 cellular response to chemical stimulus
266 GO:0032270 positive regulation of cellular protein metabolic process
266 GO:0048584 positive regulation of response to stimulus
266 GO:0006508 proteolysis
266 GO:0050790 regulation of catalytic activity
266 GO:0031326 regulation of cellular biosynthetic process
266 GO:0010468 regulation of gene expression
266 GO:2000026 regulation of multicellular organismal development
266 GO:0019219 regulation of nucleobase-containing compound metabolic process
266 GO:0009966 regulation of signal transduction
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
303 GO:0007165 signal transduction
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
314 GO:0010467 gene expression
314 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
342 GO:0006139 nucleobase-containing compound metabolic process
342 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
455 GO:0010468 regulation of gene expression
471 GO:0034645 cellular macromolecule biosynthetic process
471 GO:0044271 cellular nitrogen compound biosynthetic process
471 GO:0006464 cellular protein modification process
471 GO:0031324 negative regulation of cellular metabolic process
471 GO:0010605 negative regulation of macromolecule metabolic process
471 GO:0010604 positive regulation of macromolecule metabolic process
471 GO:0051173 positive regulation of nitrogen compound metabolic process
471 GO:0051252 regulation of RNA metabolic process
471 GO:0010468 regulation of gene expression
471 GO:0007165 signal transduction
479 GO:0016070 RNA metabolic process
479 GO:0034645 cellular macromolecule biosynthetic process
479 GO:0044271 cellular nitrogen compound biosynthetic process
479 GO:0044267 cellular protein metabolic process
479 GO:0010468 regulation of gene expression
479 GO:0007165 signal transduction
490 GO:0031325 positive regulation of cellular metabolic process
490 GO:0010604 positive regulation of macromolecule metabolic process
490 GO:0051173 positive regulation of nitrogen compound metabolic process
490 GO:0009966 regulation of signal transduction
490 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
569 GO:0007165 signal transduction
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
605 GO:0007165 signal transduction
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
692 GO:0016070 RNA metabolic process
692 GO:0044271 cellular nitrogen compound biosynthetic process
692 GO:0010467 gene expression
692 GO:0019538 protein metabolic process
692 GO:2000112 regulation of cellular macromolecule biosynthetic process
701 GO:0031327 negative regulation of cellular biosynthetic process
701 GO:0010558 negative regulation of macromolecule biosynthetic process
701 GO:0051172 negative regulation of nitrogen compound metabolic process
701 GO:0006357 regulation of transcription from RNA polymerase II promoter
701 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
29 GO:0005634 nucleus
51 GO:0005634 nucleus
54 GO:0070013 intracellular organelle lumen
54 GO:0005634 nucleus
102 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
107 GO:0005829 cytosol
107 GO:0005654 nucleoplasm
134 GO:0005829 cytosol
134 GO:0005634 nucleus
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
220 GO:0005634 nucleus
248 GO:0031981 nuclear lumen
266 GO:0031410 cytoplasmic vesicle
266 GO:0012505 endomembrane system
266 GO:0005576 extracellular region
266 GO:0070013 intracellular organelle lumen
266 GO:0005634 nucleus
266 GO:0005886 plasma membrane
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
306 GO:0070062 extracellular exosome
314 GO:0005829 cytosol
314 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
342 GO:0012505 endomembrane system
342 GO:0044428 nuclear part
357 GO:0005654 nucleoplasm
394 GO:0005654 nucleoplasm
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
455 GO:0005634 nucleus
471 GO:0005654 nucleoplasm
479 GO:0070013 intracellular organelle lumen
479 GO:0044428 nuclear part
490 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
544 GO:0005829 cytosol
544 GO:0005634 nucleus
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
692 GO:0031981 nuclear lumen
701 GO:0005654 nucleoplasm
817 GO:0070013 intracellular organelle lumen
817 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0001657 ureteric bud development IEA
GO:0001666 response to hypoxia IMP
GO:0001701 in utero embryonic development IEA
GO:0001707 mesoderm formation IEA
GO:0001756 somitogenesis IEA
GO:0001889 liver development IEA
GO:0001947 heart looping IEA
GO:0002076 osteoblast development IEA
GO:0002520 immune system development IEA
GO:0006351 transcription, DNA-templated IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA
GO:0006810 transport IDA
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
GO:0006955 immune response IMP
GO:0007050 cell cycle arrest IMP
GO:0007179 transforming growth factor beta receptor signaling pathway TAS
GO:0007183 SMAD protein complex assembly IDA
GO:0007492 endoderm development IEA
GO:0009880 embryonic pattern specification IEA
GO:0010628 positive regulation of gene expression IDA
GO:0010694 positive regulation of alkaline phosphatase activity IEA
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA
GO:0016202 regulation of striated muscle tissue development IEA
GO:0016579 protein deubiquitination TAS
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IMP
GO:0019049 evasion or tolerance of host defenses by virus IDA
GO:0023019 signal transduction involved in regulation of gene expression IEA
GO:0030308 negative regulation of cell growth IDA
GO:0030335 positive regulation of cell migration IEA
GO:0030501 positive regulation of bone mineralization IEA
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
GO:0030878 thyroid gland development IEA
GO:0031053 primary miRNA processing TAS
GO:0032332 positive regulation of chondrocyte differentiation IEA
GO:0032731 positive regulation of interleukin-1 beta production IEA
GO:0032909 regulation of transforming growth factor beta2 production IMP
GO:0032916 positive regulation of transforming growth factor beta3 production IEA
GO:0032924 activin receptor signaling pathway IMP
GO:0033689 negative regulation of osteoblast proliferation IEA
GO:0035413 positive regulation of catenin import into nucleus IEA
GO:0038092 nodal signaling pathway IMP
GO:0042060 wound healing TAS
GO:0042110 T cell activation IEA
GO:0042177 negative regulation of protein catabolic process IEA
GO:0042993 positive regulation of transcription factor import into nucleus IDA
GO:0043066 negative regulation of apoptotic process IEA
GO:0045216 cell-cell junction organization IMP
GO:0045429 positive regulation of nitric oxide biosynthetic process IDA
GO:0045599 negative regulation of fat cell differentiation IDA
GO:0045668 negative regulation of osteoblast differentiation IEA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045930 negative regulation of mitotic cell cycle IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS
GO:0048340 paraxial mesoderm morphogenesis IEA
GO:0048589 developmental growth IEA
GO:0048617 embryonic foregut morphogenesis IEA
GO:0048701 embryonic cranial skeleton morphogenesis IEA
GO:0050678 regulation of epithelial cell proliferation IEA
GO:0050728 negative regulation of inflammatory response IEA
GO:0050776 regulation of immune response IEA
GO:0050821 protein stabilization IEA
GO:0050927 positive regulation of positive chemotaxis IEA
GO:0051098 regulation of binding IEA
GO:0051481 negative regulation of cytosolic calcium ion concentration IDA
GO:0051496 positive regulation of stress fiber assembly IEA
GO:0051894 positive regulation of focal adhesion assembly IEA
GO:0060039 pericardium development IEA
GO:0060070 canonical Wnt signaling pathway IEA
GO:0060290 transdifferentiation IEA
GO:0060395 SMAD protein signal transduction IEA
GO:0061045 negative regulation of wound healing IEA
GO:0061767 negative regulation of lung blood pressure IEA
GO:0070306 lens fiber cell differentiation IEA
GO:0071560 cellular response to transforming growth factor beta stimulus IDA
GO:0097191 extrinsic apoptotic signaling pathway IMP
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
GO:1901203 positive regulation of extracellular matrix assembly IDA
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IMP
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005637 nuclear inner membrane IDA
GO:0005654 nucleoplasm TAS
GO:0005667 transcription factor complex IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0043235 receptor complex IMP
GO:0071141 SMAD protein complex IDA
GO:0071144 SMAD2-SMAD3 protein complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0005886 plasma membrane 1.05e-21 5.03e-79
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005667 transcription factor complex GO:0005737 cytoplasm 9.09e-11 9.47e-68
GO:0005667 transcription factor complex GO:0005886 plasma membrane 2.30e-33 1.58e-200
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
MEOX2_HUMAN Yes: P50222 (MoonDB)
CRX_HUMAN No
NEDD4_HUMAN No
ZCH14_HUMAN No
ZBTB3_HUMAN No
T22D4_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
PSB1_HUMAN No
LHX3_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
FOXH1_HUMAN No
CASL_HUMAN No
XRCC6_HUMAN Yes: P12956 (MoonDB)
PIN1_HUMAN No
COR1A_HUMAN No
KANL1_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
GGA1_HUMAN No
WWP2_HUMAN Yes: O00308 (MoonDB)
ZN329_HUMAN No
RU17_HUMAN Yes: P08621 (MoonDB)
TGM2_HUMAN No
2AAA_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
CHRD_HUMAN No
WWP1_HUMAN Yes: Q9H0M0 (MoonDB)
HNRPK_HUMAN Yes: P61978 (MoonDB)
TEKT4_HUMAN No
UBQL4_HUMAN No
AKT1_HUMAN No
FOS_HUMAN No
CCD33_HUMAN No
CFLAR_HUMAN No
FBLN1_HUMAN No
CN105_HUMAN No
RFA1_HUMAN No
RBX1_HUMAN No
MAX_HUMAN No
EPAS1_HUMAN No
ANK3_HUMAN No
TLR4_HUMAN No
AATF_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
APMAP_HUMAN No
APOB_HUMAN No
ATF2_HUMAN No
CBP_HUMAN No
CCNT1_HUMAN No
CDK2_HUMAN No
CDK4_HUMAN No
CFAH_HUMAN No
CFDP1_HUMAN No
CP11A_HUMAN No
CPSF7_HUMAN No
CPTP_HUMAN No
CREST_HUMAN No
CSH1_HUMAN No
CSH2_HUMAN No
CXXC5_HUMAN No
DEDD_HUMAN No
DNJB4_HUMAN No
DNJB5_HUMAN No
EP300_HUMAN Yes: Q09472 (MoonDB)
ETS1_HUMAN Yes: P14921 (MoonDB)
FLI1_HUMAN No
GANP_HUMAN No
GIT2_HUMAN No
GMEB1_HUMAN No
GO45_HUMAN No
HDAC1_HUMAN No
HEY1_HUMAN No
HEYL_HUMAN No
HPT_HUMAN No
HXC11_HUMAN No
IL27B_HUMAN No
ISL1_HUMAN No
JUNB_HUMAN No
JUN_HUMAN No
KCC2G_HUMAN No
KDM2A_HUMAN No
KMT2B_HUMAN No
LBP_HUMAN No
M3K7_HUMAN Yes: O43318 (MoonDB)
MK08_HUMAN No
MPIP1_HUMAN No
MTF2_HUMAN No
MYC_HUMAN No
MYD88_HUMAN No
NCOA6_HUMAN No
NR4A1_HUMAN Yes: P22736 (MoonDB)
PAPP1_HUMAN No
PARP4_HUMAN No
PCDH1_HUMAN No
PCKGM_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PIAS4_HUMAN No
PLAG1_HUMAN No
PLAL1_HUMAN No
PLMN_HUMAN No
PP12C_HUMAN No
PRDM4_HUMAN No
PROX1_HUMAN No
PSD11_HUMAN No
RANB9_HUMAN No
RECO_HUMAN No
RIOK2_HUMAN No
RLA0_HUMAN No
RNF31_HUMAN No
S10A4_HUMAN No
SETD2_HUMAN No
SIA7B_HUMAN No
SKIL_HUMAN No
SKI_HUMAN No
SMAD1_HUMAN Yes: Q15797 (MoonDB)
SMAD2_HUMAN No
SMAD4_HUMAN No
SMAD7_HUMAN No
SMUF1_HUMAN No
SMUF2_HUMAN No
SNW1_HUMAN No
SP130_HUMAN No
SP1_HUMAN No
SQSTM_HUMAN Yes: Q13501 (MoonDB)
SRTD1_HUMAN No
SVEP1_HUMAN No
TANK_HUMAN No
TF65_HUMAN No
TMED1_HUMAN No
TRFE_HUMAN No
TYDP2_HUMAN No
UBP7_HUMAN No
VDR_HUMAN Yes: P11473 (MoonDB)
VISTA_HUMAN No
ZC12A_HUMAN No
ZEB2_HUMAN No
ZEP1_HUMAN Yes: P15822 (MoonDB)
ZFYV9_HUMAN No
ZMY11_HUMAN No
ZNF83_HUMAN No
PMID Article Title
8673135 Mad-related genes in the human.
8774881 Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
9311995 TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
9464505 Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.
9665135 The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3.
9670020 Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.
9732876 Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
9741623 Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
9843571 TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.
9865696 SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.
9892009 Roles of pathway-specific and inhibitory Smads in activin receptor signaling.
10995748 Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.
11224571 The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.
11274402 Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.
11278756 Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.
11387212 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
11427533 TGIF2 interacts with histone deacetylase 1 and represses transcription.
12154125 Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control.
12370310 Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
12686552 Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.
14525983 DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15241418 Cyclin-dependent kinases regulate the antiproliferative function of Smads.
15350224 Structural basis of heteromeric smad protein assembly in TGF-beta signaling.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15561701 Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.
15588252 The Smad3 linker region contains a transcriptional activation domain.
15601644 MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.
15647271 The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.
15799969 Nuclear targeting of transforming growth factor-beta-activated Smad complexes.
15897867 Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.
16156666 Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
16200078 Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.
16449645 The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
16572171 Analysis of the DNA sequence and duplication history of human chromosome 15.
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.
16751102 Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
16862174 Smad3 is acetylated by p300/CBP to regulate its transactivation activity.
16959974 The consensus coding sequences of human breast and colorectal cancers.
17099224 Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.
17292623 Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
17327236 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
18669648 A quantitative atlas of mitotic phosphorylation.
18794808 Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.
19049980 SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.
19218245 Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
19289081 Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20129061 TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
20935647 IL-37 is a fundamental inhibitor of innate immunity.
21217753 Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis.
21269460 Initial characterization of the human central proteome.
21778426 Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms.
21947082 USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
22781750 Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24324267 Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.
24613385 Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.
24627487 C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.
25105025 TGF-beta signaling cooperates with AT motif-binding factor-1 for repression of the alpha -fetoprotein promoter.
25133494 Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor beta Signaling.
OMIM ID Disease Name
114500 Colorectal cancer
613795 Loeys-Dietz syndrome 3
Domain Name Domain ID Source
SMAD_dom_Dwarfin-type IPR001132 InterPro
MAD_homology1_Dwarfin-type IPR003619 InterPro
SMAD_FHA_dom_sf IPR008984 InterPro
MAD_homology_MH1 IPR013019 InterPro
Dwarfin IPR013790 InterPro
SMAD-like_dom_sf IPR017855 InterPro
SMAD_MH1_sf IPR036578 InterPro
MH1 PF03165 Pfam
MH2 PF03166 Pfam
MH1 PS51075 PROSITE
MH2 PS51076 PROSITE
PTHR13703 PTHR13703 PANTHER
S71798 S71798 PIR
DWA SM00523 SMART
DWB SM00524 SMART
SSF49879 SSF49879 SUPFAM
SSF56366 SSF56366 SUPFAM