Protein: P62837

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62837 (Uniprot) UB2D2_HUMAN UBE2D2 Ubiquitin-conjugating enzyme E2 D2 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IDA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006464 cellular protein modification process TAS
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0016567 protein ubiquitination TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051865 protein autoubiquitination IDA
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0070936 protein K48-linked ubiquitination IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex IDA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
GO:0043234 protein complex IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
TRI27_HUMAN Yes: P14373 (MoonDB)
NEDD4_HUMAN No
TRI54_HUMAN No
DTX2_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC2_HUMAN No
BIRC7_HUMAN No
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
RNF5_HUMAN No
UBE3A_HUMAN Yes: Q05086 (MoonDB)
RNF8_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
TRI39_HUMAN No
ARI2_HUMAN No
TRI50_HUMAN No
AMFR_HUMAN No
ARRD3_HUMAN No
BFAR_HUMAN No
BIRC3_HUMAN No
BIRC8_HUMAN No
BRCA1_HUMAN No
CAPS2_HUMAN No
CBLB_HUMAN No
CBL_HUMAN No
CHFR_HUMAN No
CNOT4_HUMAN No
CUL1_HUMAN No
DTX1_HUMAN No
DTX3L_HUMAN No
DTX3_HUMAN No
DUS7_HUMAN No
DZIP3_HUMAN No
EI24_HUMAN No
ELF3_HUMAN No
GOLI_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
LTN1_HUMAN No
M3K1_HUMAN No
MARH3_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
MDM4_HUMAN Yes: O15151 (MoonDB)
MGRN1_HUMAN No
MIB1_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
MUL1_HUMAN No
NED4L_HUMAN No
NEDD8_HUMAN Yes: Q15843 (MoonDB)
NFX1_HUMAN No
OTUB1_HUMAN No
PHF7_HUMAN No
PJA2_HUMAN No
PTEN_HUMAN No
Q8NEX1_HUMAN No
RBX2_HUMAN No
RFWD3_HUMAN No
RING1_HUMAN No
RING2_HUMAN No
RL40_HUMAN No
RMD5B_HUMAN No
RN103_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
RN114_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN125_HUMAN No
RN126_HUMAN No
RN138_HUMAN No
RN150_HUMAN No
RN165_HUMAN No
RN166_HUMAN No
RN167_HUMAN Yes: Q9H6Y7 (MoonDB)
RN181_HUMAN No
RN185_HUMAN No
RN186_HUMAN No
RNF10_HUMAN No
RNF11_HUMAN No
RNF12_HUMAN No
RNF13_HUMAN No
RNF14_HUMAN No
RNF25_HUMAN No
RNF26_HUMAN No
RNF31_HUMAN No
RNF37_HUMAN No
RNF38_HUMAN No
RNF43_HUMAN No
RNF4_HUMAN No
RNFT1_HUMAN No
RS17_HUMAN No
RS7_HUMAN No
RSPRY_HUMAN No
SNURF_HUMAN No
TOPRS_HUMAN No
TRAF6_HUMAN Yes: Q9Y4K3 (MoonDB)
TRAF7_HUMAN No
TRI10_HUMAN No
TRI11_HUMAN No
TRI17_HUMAN No
TRI18_HUMAN No
TRI25_HUMAN No
TRI26_HUMAN No
TRI31_HUMAN No
TRI35_HUMAN No
TRI37_HUMAN No
TRI38_HUMAN No
TRI43_HUMAN No
TRI45_HUMAN No
TRI55_HUMAN No
TRI62_HUMAN No
TRIM2_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM7_HUMAN No
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBE4A_HUMAN No
UBTD1_HUMAN No
UFL1_HUMAN No
UFM1_HUMAN No
UHRF2_HUMAN No
ZN363_HUMAN No
ZNFX1_HUMAN No
ZNRF1_HUMAN No
ZNRF2_HUMAN No
ZNRF4_HUMAN No
PMID Article Title
7724550 Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).
8530467 Identification of a family of closely related human ubiquitin conjugating enzymes.
10329681 Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.
10918611 SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.
12036302 PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15001359 An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.
15280377 Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15522302 Solution structure of the ubiquitin-conjugating enzyme UbcH5B.
16112646 Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.
17588522 E3-independent monoubiquitination of ubiquitin-binding proteins.
18042044 Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
18359941 Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.
18703417 Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.
19854139 Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
20152160 Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates.
20403326 Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.
20525694 The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.
21269460 Initial characterization of the human central proteome.
26656854 Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
No results found.
Domain Name Domain ID Source
I59365 I59365 PIR
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD