UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P30822 (Uniprot)	XPO1_YEAST	CRM1	Exportin-1	yeast	No

Protein Function

Uniprot: Receptor for the leucine-rich nuclear export signal (NES).

MoonDB Dissimilar Functions

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0044260	cellular macromolecule metabolic process	901, 989	GO:0033036	macromolecule localization	1156	1.18e-20	4.59e-11
GO:0044260	cellular macromolecule metabolic process	901, 989	GO:0070727	cellular macromolecule localization	1184	2.61e-07	8.40e-04
GO:0008104	protein localization	1184	GO:0044260	cellular macromolecule metabolic process	1268, 1269	7.50e-19	5.37e-13

MoonDB Network Modules

Biological Processes

Module ID (MoonGO)	GO ID (BP)	GO Name
901	GO:0016070	RNA metabolic process
901	GO:0010467	gene expression
904	GO:0010467	gene expression
964	GO:0006397	mRNA processing
964	GO:0000956	nuclear-transcribed mRNA catabolic process
964	GO:0022613	ribonucleoprotein complex biogenesis
989	GO:0016070	RNA metabolic process
989	GO:0010467	gene expression
990	GO:0006464	cellular protein modification process
1004	GO:0090304	nucleic acid metabolic process
1137	GO:0010467	gene expression
1137	GO:0090304	nucleic acid metabolic process
1138	GO:0010467	gene expression
1156	GO:0070727	cellular macromolecule localization
1184	GO:0034613	cellular protein localization
1268	GO:0016070	RNA metabolic process
1268	GO:0051656	establishment of organelle localization
1268	GO:0010467	gene expression
1268	GO:0071426	ribonucleoprotein complex export from nucleus
1269	GO:0016070	RNA metabolic process
1301	GO:0010467	gene expression
1301	GO:0006139	nucleobase-containing compound metabolic process
1332	GO:0044271	cellular nitrogen compound biosynthetic process

Cellular Components

Module ID (MoonGO)	GO ID (CC)	GO Name
901	GO:0005634	nucleus
903	GO:0005634	nucleus
904	GO:0005634	nucleus
914	GO:0043232	intracellular non-membrane-bounded organelle
964	GO:0000932	P-body
964	GO:0005634	nucleus
989	GO:0005634	nucleus
990	GO:0005634	nucleus
1004	GO:0005634	nucleus
1016	GO:0005634	nucleus
1105	GO:0043232	intracellular non-membrane-bounded organelle
1105	GO:0005634	nucleus
1125	GO:0005634	nucleus
1137	GO:0043232	intracellular non-membrane-bounded organelle
1137	GO:0005634	nucleus
1138	GO:0005634	nucleus
1158	GO:0005634	nucleus
1170	GO:0044427	chromosomal part
1170	GO:0044428	nuclear part
1184	GO:0005634	nucleus
1192	GO:0031090	organelle membrane
1222	GO:0005634	nucleus
1268	GO:0005634	nucleus
1269	GO:0005634	nucleus
1301	GO:0005634	nucleus

Protein GO Annotations

Biological Processes

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000055	ribosomal large subunit export from nucleus	IMP
GO:0000056	ribosomal small subunit export from nucleus	IBA
GO:0006406	mRNA export from nucleus	IMP
GO:0006611	protein export from nucleus	IMP
GO:0034501	protein localization to kinetochore	IGI
GO:0046825	regulation of protein export from nucleus	IBA

Cellular Components

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000776	kinetochore	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IBA
GO:0005816	spindle pole body	IDA
GO:0048471	perinuclear region of cytoplasm	IEA

Dissimilar Cellular Components (PrOnto)

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000776	kinetochore	GO:0005737	cytoplasm	3.18e-02	1.76e-05
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

All Protein Interactions

Interactor	Also a MoonDB EMF protein
DCP2_YEAST	No
MED17_YEAST	No
NUP1_YEAST	No
ACE2_YEAST	No
RCC1_YEAST	No
ACF4_YEAST	No
RBS1_YEAST	No
MPC54_YEAST	No
PBP1_YEAST	No
LTV1_YEAST	No
PAT1_YEAST	No
YSC84_YEAST	No
SPO74_YEAST	No
LSB3_YEAST	No
EDC3_YEAST	No
DCP1_YEAST	No
PEX2_YEAST	No
SPC72_YEAST	No
NUP49_YEAST	No
NUP57_YEAST	No
PEX19_YEAST	No
AP1_YEAST	No
BECN1_YEAST	No
CTL1_YEAST	No
DAD1_YEAST	No
ECM30_YEAST	No
FMP52_YEAST	No
GGA2_YEAST	No
GPB1_YEAST	No
GPP2_YEAST	No
GSP1_YEAST	Yes: P32835 (MoonDB)
GST2_YEAST	No
IBD2_YEAST	No
IVY1_YEAST	No
KSP1_YEAST	No
LCD1_YEAST	No
LCL1_YEAST	No
MDM32_YEAST	No
NAB6_YEAST	No
NDI1_YEAST	No
NU100_YEAST	No
NU145_YEAST	No
NU159_YEAST	No
NUP42_YEAST	No
PCD1_YEAST	No
PRI2_YEAST	No
SCD5_YEAST	No
SERC_YEAST	No
SGM1_YEAST	No
SHE1_YEAST	No
SLZ1_YEAST	No
VHC1_YEAST	No
YD102_YEAST	No
YEF3_YEAST	No
YFG8_YEAST	No
YGO9_YEAST	No
YJ31_YEAST	No
YM11_YEAST	No
YRB1_YEAST	No
YRB2_YEAST	No

Publications Associated

PMID	Article Title
1448080	Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.
8701610	Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII.
9169869	The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
9323132	Exportin 1 (Crm1p) is an essential nuclear export factor.
14562095	Global analysis of protein localization in budding yeast.
14562106	Global analysis of protein expression in yeast.
15020406	The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing.
15769879	Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.
18407956	A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198	Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.

OMIM Diseases Associated

No results found.

Protein Domains Associated

Domain Name	Domain ID	Source
Importin-beta_N	IPR001494	InterPro
ARM-like	IPR011989	InterPro
Exportin-1/Importin-b-like	IPR013598	InterPro
CRM1_C_dom	IPR014877	InterPro
ARM-type_fold	IPR016024	InterPro
IBN_N	PF03810	Pfam
Xpo1	PF08389	Pfam
CRM1_C	PF08767	Pfam
IMPORTIN_B_NT	PS50166	PROSITE
S57681	S57681	PIR
IBN_N	SM00913	SMART
CRM1_C	SM01102	SMART
SSF48371	SSF48371	SUPFAM