Protein: P29350

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P29350 (Uniprot) PTN6_HUMAN PTPN6 Tyrosine-protein phosphatase non-receptor type 6 human No
Uniprot: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 355 GO:0034641 cellular nitrogen compound metabolic process 786 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
786 GO:0044271 cellular nitrogen compound biosynthetic process
786 GO:0044267 cellular protein metabolic process
786 GO:0006139 nucleobase-containing compound metabolic process
786 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
117 GO:0005634 nucleus
355 GO:0044459 plasma membrane part
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
786 GO:0005829 cytosol
786 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002244 hematopoietic progenitor cell differentiation IEA
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0006470 protein dephosphorylation IDA
GO:0006915 apoptotic process TAS
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0008283 cell proliferation IDA
GO:0008284 positive regulation of cell proliferation IMP
GO:0008285 negative regulation of cell proliferation NAS
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:0030154 cell differentiation IDA
GO:0030168 platelet activation TAS
GO:0030220 platelet formation IEA
GO:0031295 T cell costimulation TAS
GO:0033277 abortive mitotic cell cycle IEA
GO:0033630 positive regulation of cell adhesion mediated by integrin IEA
GO:0035335 peptidyl-tyrosine dephosphorylation IMP
GO:0035556 intracellular signal transduction IEA
GO:0035855 megakaryocyte development IEA
GO:0042130 negative regulation of T cell proliferation IEA
GO:0042267 natural killer cell mediated cytotoxicity IEA
GO:0043312 neutrophil degranulation TAS
GO:0043407 negative regulation of MAP kinase activity IEA
GO:0045577 regulation of B cell differentiation IEA
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
GO:0050853 B cell receptor signaling pathway IEA
GO:0050859 negative regulation of B cell receptor signaling pathway IEA
GO:0050860 negative regulation of T cell receptor signaling pathway IEA
GO:0050900 leukocyte migration TAS
GO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS
GO:0070372 regulation of ERK1 and ERK2 cascade IDA
GO:0070527 platelet aggregation IEA
GO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005634 nucleus IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005911 cell-cell junction IEA
GO:0016020 membrane TAS
GO:0035580 specific granule lumen TAS
GO:0042105 alpha-beta T cell receptor complex IEA
GO:0043234 protein complex IMP
GO:0070062 extracellular exosome IDA
GO:1904724 tertiary granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005730 nucleolus 6.04e-15 4.85e-05
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005730 nucleolus GO:0016020 membrane 8.89e-46 1.83e-10
PMID Article Title
1652101 A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
1732748 Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
1736296 Isolation of a src homology 2-containing tyrosine phosphatase.
7665165 Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
7781604 Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
9074930 Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
9285411 A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
9712903 High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages.
9774441 Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
9842885 The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.
10497187 Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity.
10574931 Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.
11162587 Molecular cloning and characterization of SPAP1, an inhibitory receptor.
11266449 Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
11414741 Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
12482860 Crystal structure of human protein-tyrosine phosphatase SHP-1.
14597715 The inhibitory potential of Fc receptor homolog 4 on memory B cells.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15184070 IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
16541075 The finished DNA sequence of human chromosome 12.
18604210 An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
19591923 The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19843936 FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
20933011 FCRL6 receptor: expression and associated proteins.
21258366 Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
21262353 Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.
21269460 Initial characterization of the human central proteome.
21465528 Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
23112346 Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
S20825 B42031 PIR
PTPase_domain IPR000242 InterPro
TYR_PHOSPHATASE_dom IPR000387 InterPro
SH2 IPR000980 InterPro
Tyr_Pase_cat IPR003595 InterPro
Tyr_Pase_non-rcpt_typ-6/11 IPR012152 InterPro
Tyr_Pase_AS IPR016130 InterPro
Prot-tyrosine_phosphatase-like IPR029021 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
Y_phosphatase PF00102 Pfam
Tyr-Ptase_nr_6 PIRSF000929 PIRSF
SH2DOMAIN PR00401 PRINTS
PRTYPHPHTASE PR00700 PRINTS
TYR_PHOSPHATASE_1 PS00383 PROSITE
SH2 PS50001 PROSITE
TYR_PHOSPHATASE_PTP PS50055 PROSITE
TYR_PHOSPHATASE_2 PS50056 PROSITE
PTPc SM00194 SMART
SH2 SM00252 SMART
PTPc_motif SM00404 SMART
SSF52799 SSF52799 SUPFAM
SSF55550 SSF55550 SUPFAM